AMANTADINE HYDROCHLORIDE

Amantadine hydrochloride received FDA approval on 24/08/2017 for treatment of uncontrolled, involuntary muscle movements in patients with Parkinson's disease.

To treat symptoms of Parkinson’s disease, such as muscle stiffness, tremors, and slow movement To improve movement control and coordination To help reduce difficulty in daily activities like walking, dressing, or writing To support better quality of life in patients with movement disorders

Amantadine hydrochloride is administered orally and is available in capsule, tablet, and oral solution formulations. It is typically taken once or twice daily, depending on the clinical indication and patient-specific factors, and may be taken with or without food, although taking it with food can help minimize gastrointestinal upset. Doses are generally scheduled earlier in the day to reduce the risk of insomnia. Because amantadine is primarily eliminated by the kidneys, dose adjustment is required in patients with renal impairment, and abrupt discontinuation should be avoided, with gradual tapering recommended when stopping therapy.

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them. Serious Convulsions (fits) Fainting Common Swollen ankles Red blotchy spots on the skin Depression and confusion Difficulty sleeping Nightmares and feeling nervous Headache Dizziness Difficulty in controlling movements Slurred speech Fast or irregular heartbeat Low blood pressure when standing up. constipation Sweating Dry mouth

Do not take amantadine if you are allergic to amantadine hydrochloride or any of its components. Avoid use if you have lactose intolerance, epilepsy (seizures), peptic ulcers, or severe kidney disease. Amantadine is not recommended during pregnancy, when planning pregnancy, or while breastfeeding unless clearly advised by a doctor. Consult your doctor before use if you have liver or kidney problems, heart disease, mental health disorders (such as schizophrenia), or glaucoma. Always inform your doctor about your complete medical history and all medications you are taking before starting amantadine treatment.

Inform your doctor if you are pregnant or planning to become pregnant, as amantadine is not advisable during pregnancy due to potential risk to the baby. Avoid amantadine while breastfeeding, as the medicine can pass into breast milk. Consult your doctor before taking amantadine if you have lung or liver disease. Avoid alcohol during treatment, as it may increase side effects. Use caution when driving or operating machinery, as amantadine may cause dizziness or blurred vision

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