ATAZANAVIR,LAMIVUDINE,RITONAVIR,TENOFOVIR DISOPROXIL FUMARATE
Background and Date of Approval
Atazanavir, lamivudine, ritonavir, and tenofovir disoproxil fumarate are antiretroviral medicines used in the treatment of HIV (human immunodeficiency virus) infection.
Uses
Atazanavir, Lamivudine, Ritonavir, Tenofovir Disoproxil Fumarate has been developed to treat Human Immunodeficiency Virus (HIV-1). It is a nucleotide reverse transcriptase inhibitor (NRTI) and works by inhibiting the enzymes (HIV reverse transcriptase) important for virus replication. This tablet is not studied in patients over 65 years of age.
How is it administered?
Atazanavir, Lamivudine, Ritonavir, Tenofovir Disoproxil Fumarate are film-coated tablets. The usual recommended dosage of this medication is one tablet every day, with or without food. Your physician will choose the dosage and administration frequency based on the medical condition because it differs for each person. Do not crush, chew or break the tablet.
Side Effects
The common side effects that are likely to occur while you are on the treatment with Atazanavir, Lamivudine, Ritonavir, Tenofovir Disoproxil Fumarate tablet are headach, stomach pain, tiredness, bloating, flatulence, low phosphate levels in the blood, diarrhea, dizziness, joint pain, sickness, rash, weakness. Some serious adverse reactions include pancreas problems, kidney damage, deep, rapid breathing, drowsiness, nausea, vomiting, lactic acidosis (excess lactic acid), infection, increased liver enzymesIf you experience any allergic reactions after taking this tablet, report to your doctor immediately.
Warnings
Do not take this medication if you have experienced hypersensitivity reactions to Atazanavir, Lamivudine, Ritonavir, Tenofovir Disoproxil Fumarate, or any of its ingredients. During the Atazanavir, Lamivudine, Ritonavir, Tenofovir Disoproxil Fumarate Tablet treatment, your doctor may periodically monitor your blood counts, bone mineral density, liver and kidney parameters to prevent serious complications. Report to your doctor if you have had a history of heart failure, pancreatitis, bone disease, fractures, liver or kidney problems.
Precautions
Adults of childbearing potential should consider using an effective contraceptive to prevent unwanted pregnancy. If you are pregnant or think you might be pregnant, your physician might suggest an alternative treatment, as this medication is not recommended during early pregnancy. Breastfeeding is not recommended due to the potential transmission of HIV from the mother to the baby.
Word of Advice
Atazanavir, Lamivudine, Ritonavir, and Tenofovir Disoproxil Fumarate may cause dizziness and fatigue. Avoid driving or operating machinery during treatment. Consult your doctor before starting this medication. This combination does not reduce the risk of HIV transmission to others through sexual contact or blood exposure. Continued adherence to the medication regimen is necessary to prevent disease progression.
References
Goodman & Gilmanâs, The Pharmacological Basics of Therapeutics, Antiretroviral agents and treatment of HIV infection, 12th edition, 2011, 1632-1634. KD Tripathi, Essentials of Medical Pharmacology, Antiviral drugs, 7th edition, 2013, 809-810. Cipla Ltd, US Food and Drug Administration, [ Revised on October 2017] [ Accessed on 14th June 2021], https://www.accessdata.fda.gov/drugsatfda_docs/pepfar/206451PI.pdf Cipla (EU) Limited, Electronic Medicines Compendium (emc), [ Revised on October 2017] [ Accessed on 14th June 2021], https://www.medicines.org.uk/emc/files/pil.10500.pdf
Frequently Asked Questions
Can you consume alcohol while on treatment with atazanavir, Lamivudine, Ritonavir, and Atazanavir, Lamivudine, Ritonavir, Tenofovir Disoproxil Fumarate ?
No, you should not consume alcohol while on this treatment. It adds to the risk of liver injury. Atazanavir, Lamivudine, Ritonavir, and Atazanavir, Lamivudine, Ritonavir, Tenofovir Disoproxil Fumarate are associated with a higher risk of liver damage and impairment.
What are the symptoms of lactic acidosis?
Unusual weakness, tiredness, muscle pain, trouble breathing, stomach pain, nausea, vomiting, dizziness, lightheadedness, irregular heartbeat, and cold in your arms and legs are the most prominent symptoms of lactic acidosis.
What are Atazanavir, Lamivudine, Ritonavir, Atazanavir, Lamivudine, Ritonavir, Tenofovir Disoproxil Fumarate risk factors?
Patients consuming this medicine may develop immune reconstitution syndrome, diabetes mellitus, excessive body fat, and hyperglycemia. Most patients experience asymptomatic hyperbilirubinemia (increase in bilirubin) after consuming Atazanavir, Lamivudine, Ritonavir, Atazanavir, Lamivudine, Ritonavir, Tenofovir Disoproxil Fumarate.
What is the combination of Atazanavir, Lamivudine, Ritonavir, and Atazanavir, Lamivudine, Ritonavir, Tenofovir Disoproxil Fumarate?
Atazanavir, Lamivudine, Ritonavir, Atazanavir, Lamivudine, Ritonavir, Tenofovir Disoproxil Fumarate are the combination of Atazanavir, Lamivudine, Ritonavir, Atazanavir, Lamivudine, Ritonavir, Tenofovir Disoproxil Fumarate.
Can I keep Atazanavir, Lamivudine, Ritonavir, Atazanavir, Lamivudine, Ritonavir, Tenofovir Disoproxil Fumarate in the freezer?
No, it should not be kept in freezer. The storage temperature of Atazanavir, Lamivudine, Ritonavir, and Atazanavir, Lamivudine, Ritonavir, Tenofovir Disoproxil Fumarate should not exceed 30°C.