CETRORELIX
Background and Date of Approval
Cetrorelix is a hormonal medication developed by the U.S. Food And Drug Administration for treating female infertility.
Uses
Cetrorelix helps to treat female infertility ( inability of a woman to conceive a child or carry a pregnancy to full term). This drug helps to synchronize the development of multiple follicles and ensures that they can be retrieved during the IVF procedure.
How is it administered?
Cetrorelix will be given to you by a doctor or other healthcare professional. They will administer the injection in the fatty tissues just under the skin of your belly (subcutaneously). To minimize skin irritation, your physician will select a different area of your belly for each injection.
Side Effects
The side effects known to occur commonly during the treatment with Cetrorelix are headache, nausea, abdominal discomfort, and fatigue. Some serious side effects also include injection site reactions, ovarian hyperstimulation syndrome and swelling of face, lips, tongue and throat.
Warnings
This drug is contraindicated in individuals with known hypersensitivity or allergy to it or its component. Inform your physician if you have kidney problems and liver problems. Special monitoring or dose adjustments are required in these situations. Cetrorelix is often used with other medications to stimulate the ovaries as part of fertility treatment. It can mainly increase the chance of developing Ovarian Hyperstimulation Syndrome (OHSS), a condition in which the ovaries become enlarged, and cysts may form. Contact your physician if you experience severe pelvic pain, bloating, nausea, vomiting, or sudden weight gain, as these symptoms may indicate OHSS.
Precautions
Report to your physician immediately if you experience sudden life-threatening allergic reactions such as difficulty breathing or wheezing, swelling, rash, itching, fever, and chills. This drug is not intended for use in children. Please inform your physician about any other medications you use, have recently used, or may use, as they can interact with Cetrorelix. The use of this drug in pregnant and breastfeeding women is not recommended. Consult your doctor for more advice before initiating the treatment.
Word of Advice
The process of fertility treatment can be emotionally challenging. Look for support from your partner, family, and friends groups to help you navigate any emotional ups and downs during the treatment. It is important to maintain a healthy lifestyle during fertility treatment. It includes eating a balanced diet, engaging in regular physical activity (unless advised by your healthcare provider), managing stress levels, avoiding smoking, and excessive alcohol consumption. Store the Cetrorelix medication as per the manufacturer's instructions. Please keep it in a cool, dry place and protect it from light.
References
Merck Europe BV, Electronic medicines compendium (EMC), [Revised on Jan 2021] [ Accessed on 12th June 2023], https://www.medicines.org.uk/emc/files/pil.1605.pdf EMD Serono, Inc, US Food and Drug Administration, [Revised on April 2008] [Accessed on 12th June 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/021197s010lbl.pdf Dominique Finas et al.; Cetrorelix in the treatment of female infertility and endometriosis; Expert Opinion on Pharmacotherapy; Published on Oct 2006; Accessed on 12th June 2023; https://pubmed.ncbi.nlm.nih.gov/17020439/ KD Tripathi, Essentials of Medical Pharmacology, Anterior pituitary hormones, 7th edition, 2013, 243. Bertram.G.Katzung, Basic and Clinical Pharmacology, Endocrine drugs, 14th edition, 2017, 678.
Frequently Asked Questions
Is Cetrorelix available over the counter?
No, Cetrorelix is not available over the counter. It is a prescription medication that must be obtained from a healthcare provider.
How is Cetrorelix administered?
Cetrorelix is administered as a subcutaneous injection only, meaning it is injected just beneath the skin.
What is the required duration for Cetrorelix treatment?
The duration of Cetrorelix treatment can vary depending on the individual and the ART protocol. It is usually initiated a few days before the expected time of ovulation and continues for several days.
Can Cetrorelix be used during pregnancy?
No, Cetrorelix is not intended for use during pregnancy. It prevents premature ovulation and is typically discontinued once pregnancy is achieved.
How does Cetrorelix work in IVF?
Cetrorelix is primarily used in ART procedures, such as in vitro fertilization (IVF), to prevent premature ovulation. It helps to synchronize the timing of egg retrieval and improve the success rates of these procedures.
Can Cetrorelix cause weight gain?
Weight gain is not usually reported as a side effect of Cetrorelix. If you notice any significant changes in your weight during treatment, it is best to consult your physician to determine the cause.