CILNIDIPINE,NEBIVOLOL
Background and Date of Approval
The US FDA approved cilnidipine with nebivolol on 17 December 2007 for the treatment of hypertension. This medicine is classified as an anti-hypertensive agent.
Uses
Cilnidipine + Nebivolol is used for controlling blood pressure when a single medication is ineffective. Hypertension (high blood pressure) is a medical condition in which blood exerts a force on the artery walls (blood vessels), resulting in heart disease, irregular heartbeat, and other problems.
How is it administered?
Cilnidipine+ Nebivolol can be taken with food or without food. It should be swallowed whole with a glass of water. Do not chew, crush, or break it. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition.
Side Effects
Common side are headache, constipation, cold extremities, nausea, sleepiness, tiredness, palpitations, ankle swelling, flushing, edema, dizziness, increased frequency of urination, and an unusual sensation of itching or tingling, along with potential shortness of breath.
Warnings
Do not consume Cilnidipine + Nebivolol if you are allergic to Cilnidipine and Nebivolol or any of the ingredients in the medication. Do not take Cilnidipine+ Nebivolol if you are pregnant because this may harm the unborn baby. Inform your physician if you are pregnant, suspecting, or planning to get pregnant during the treatment. Before treatment with Cilnidipine+ Nebivolol, let your physician know if you have low blood pressure (hypotension), diabetes, cardiogenic shock (sudden stopping of blood flow to the heart), hyperthyroidism (overactivity of the thyroid gland), Raynaud's disease (poor circulation in arms or legs), phaeochromocytoma and chronic bronchitis. Hence, your doctor may regularly monitor your blood pressure, electrolytes, and potassium level in your blood at regular intervals. It should not be given to children less than 12 years of age.
Precautions
Additionally, disclose if you have underlying conditions such as diabetes, heart issues, lung disease, or lactose intolerance. This medicine should be used with caution in patients with severe kidney disease. Dose adjustment is required based on the kidney condition. It is advised to monitor your blood pressure regularly. It would be best to have potassium and electrolytes check-ups while taking Cilnidipine + Nebivolol to prevent complications. Do not take this medication if a patient has asthma, wheezing, or a tumor in the adrenal gland. Taking a low-salt diet and regular exercise is recommended for better results.
Word of Advice
Inform your doctor before starting treatment with Cilnidipine + Nebivolol if you have any allergies to Cilnidipine, Nebivolol, or any other components in the formulation.
References
KD Tripathi, Essentials of Medical Pharmacology, Antiadrenergic Drugs and Drugs for Glaucoma, 7th Edition, 2013, 148-149. Torrent Pharmaceuticals, Nebicard LN. Nebivolol Hydrochloride & Cilnidipine Tablet, [Revised in February 2022] [Accessed on 18th August 2023], https://www.torrentian.com/pisheet/Upload/PI_Sheet/2995.pdf Forest Pharmaceuticals Inc., US Food and Drug Administration, [ Revised on December 2011] [ Accessed on 18th August 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021742s013lbl.pdf
Frequently Asked Questions
What class of medication is Cilnidipine + Nebivolol?
Cilnidipine + Nebivolol belongs to an antihypertensive medication class.
Is children use Cilnidipine + Nebivolol?
No, Cilnidipine + Nebivolol is not recommended for children less than 12 years of age.
How do I store Cilnidipine + Nebivolol?
Cilnidipine + Nebivolol is stored below 30°C and protects them from light and moisture. Keep this medication out of sight and reach of children.
What happens when I stop taking Cilnidipine + Nebivolol?
Sudden withdrawal of Cilnidipine + Nebivolol may raise your blood pressure and increase the risk of heart disease and stroke. Hence, it is necessary to consult your doctor before withdrawing this medication.
Is Cilnidipine + Nebivolol safe during pregnancy?
No, Cilnidipine + Nebivolol should not be used during pregnancy because it may cause harmful effects on the developing fetus.
Why has Cilnidipine + Nebivolol been prescribed to me?
Cilnidipine + Nebivolol is an antihypertensive medication. It has been prescribed to treat hypertension (high blood pressure).
What should I do if I forget to take Cilnidipine + Nebivolol?
When you remember, take Cilnidipine + Nebivolol right away. Skip the missed dose if it is almost time for your next one, and continue with your regular dosing schedule. Do not take a double dose to make up for a missing one.