COLESEVELAM
Background and Date of Approval
Colesevelam is an antihyperlipidaemic agent approved by the U.S. Food and Drug Administration in 2000 for treatment of primary hyperlipidaemia in adults.
Uses
Colesevelam is used to treat primary hyperlipidemia in adult patients. It helps lower elevated LDL cholesterol levels, which are associated with an increased risk of cardiovascular diseases. In addition to its cholesterol-lowering effects, this drug is known to improve blood sugar level control in patients with type 2 diabetes. It can help manage blood glucose levels, which is particularly beneficial for individuals with both high cholesterol and type 2 diabetes.
How is it administered?
Take the Colesevelam as your physician advises. Measuring the correct dosage and mixing it thoroughly before drinking is important. Only stop taking this powder if your doctor advises you to stop.
Side Effects
The side effects known to occur commonly during the treatment with Colesevelam are constipation, nausea and indigestion.
Warnings
Do not use this drug if you have a known allergy or sensitivity to it or any components in the medication. If you have type 2 diabetes and are taking medications to lower blood sugar, monitor your blood sugar levels closely when starting Colesevelam. Adjustments to your diabetes medications may be necessary. This drug can cause gastrointestinal side effects, including constipation, indigestion, and gas. These symptoms are more common when starting the medication or with higher doses. To minimize these effects, take this drug with meals and a full glass of water. If constipation persists, discuss it with your healthcare provider.
Precautions
There is no limited information on the safety of Colesevelam in breastfeeding and pregnant women. Consult your doctor for more advice. Individuals with severe liver disease may require adjusted dosages or closer monitoring when taking this drug. The safety and effectiveness of this medicine in children and infants have not been established. This medication is prescribed for adults, so its use in pediatric populations may require careful consideration and monitoring.
Word of Advice
Adequate fluid intake throughout the day is important, as colesevelam may cause constipation in some patients. Adherence to lifestyle measures—including regular physical activity, balanced nutrition, and other guidance from your healthcare provider—remains essential for management of your condition.
References
Daiichi Sankyo Inc, US Food and Drug Administration, [ Issued on April 2019] [Accessed on 25th Sep 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/210895s000lbl.pdf Goodman & Gilmanâs, The Pharmacological Basis of Therapeutics, Drug therapy for Hypercholesterolemia and Dyslipidaemia, 12th edition, 2011, 898-899.
Frequently Asked Questions
Should I make any dietary changes while taking Colesevelam?
To optimize the effectiveness of Colesevelam, it's advisable to follow a heart-healthy diet as recommended by your healthcare provider. This may include reducing saturated fats and cholesterol in your diet.
Are there any side effects associated with Colesevelam?
The common side effects of Colesevelam may include constipation, nausea and indigestion. Not everyone will experience these side effects, and they are usually mild. If you experience severe side effects, contact your physician.
Is Colesevelam safe during pregnancy and breastfeeding?
The safety of Colesevelam during pregnancy and breastfeeding has not been well studied. If you are pregnant, planning to become pregnant, or breastfeeding, it is highly advised to discuss the benefits and risks of using this drug with your physician before taking the medication.
Can I take other medications with Colesevelam?
Inform your physician about all the medications, supplements, and over-the-counter drugs you are taking, as there may be potential interactions with Colesevelam. Your provider can assess the safety and efficacy of combining this drug with other medications and make appropriate recommendations.
Is Colesevelam available over-the-counter (OTC)?
Colesevelam is available by prescription and is not commonly found as an over-the-counter (OTC) medication. It is important to consult with a physician for an accurate diagnosis and prescription.