CORTICOTROPIN
Background and Date of Approval
Corticotropin is a synthetic adrenocorticotropic hormone analogue that received initial approval for medical use in 1952.
Uses
Corticotropin Injection has been developed to treat infantile spasms in children below 2 years of age. Infantile spasm is a rare condition characterised by seizures and hypsarrhythmia. Corticotropin is indicated to treat acute exacerbations of multiple sclerosis, inflammatory conditions of the eye, rheumatoid arthritis and systemic lupus erythematosus. It is also recommended to detect adrenal insufficiency and pituitary-adrenal axis disorders.
How is it administered?
Corticotropin is available as a multi dose vial for injection in the dose 60IU/ml. This injection is intended for administration through subcutaneous and intramuscular routes only and the dosing varies according to body weight and disease condition.
Side Effects
The common side effects that are likely to occur while you are on the treatment with Corticotropin Injection are injection site reactions, swelling, high blood pressure, high blood glucose levels, eye problems, vomiting, diarrhoea, fever, weight gain, infections, bone problems, electrolyte imbalance. If you experience any anaphylactic or allergic reactions after taking this injection, report to your doctor immediately
Warnings
Corticotropin Injection is contraindicated in active and latent tuberculosis, herpes, and other active infections, diabetes, Cushingâs syndrome, osteoporosis, scleroderma, heart failure, uncontrolled hypertension and sensitivity to pork proteins. Contact your doctor immediately if you experience breathlessness, weakness, severe rash, swelling of arms or legs or any other anaphylactic reactions. During treatment with Corticotropin injection, your doctor may periodically monitor your blood count, blood sugar, thyroid, serum cortisol and other vital parameters to prevent serious complications. Report to your doctor if you have had a history of diabetes, heart problems, osteoporosis, hypothyroidism, peptic ulcer, cancer, obesity or acute illnesses.
Precautions
It is not known whether treatment with Corticotropin Injection alters fertility or interferes with pregnancy and breastfeeding. Tell your healthcare provider before starting treatment with Corticotropin Injection if you are pregnant, breastfeeding or planning to have a baby.
Word of Advice
Avoid driving or handling machines if you experience dizziness, tiredness, or any visual disturbances. Ensure adequate nutrition and fluid intake.
References
Duchowny MS, Chopra I, Niewoehner J, Wan GJ, Devine B, A systematic literature review and indirect treatment comparison of efficacy of repository corticotropin injection versus synthetic adrenocorticotropic hormone for infantile spasms, JHEOR, 2021, 8(1), 1-9, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7839629/pdf/jheor_2021_8_1_18727.pdf Bernard P. Schimmer, John W. Funder, Goodman & Gilmanâs Pharmacological Basis of Therapeutics, Adrenocorticotropic Hormone, Adrenal Steroids, and the Adrenal Cortex, 2018, 13th Edition, 845-861. KD Tripathi, Anterior Pituitary Hormones, Essentials of Medical Pharmacology, 8th Edition, 2019, 257-266. Tran KA, Harrod C, Bourdette DN, Cohen DM, Deodhar AA, Hartung DM. Characterization of the Clinical Evidence Supporting Repository Corticotropin Injection for FDA-Approved Indications: A Scoping Review. JAMA Intern Med. 2022, 182(2), 206â217, https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2787088
Frequently Asked Questions
Is it safe to undergo surgery while on treatment with Corticotropin Injection?
It is not recommended to take Corticotropin Injection at times of critical illness and surgeries as the chances of complications will be high. Inform your healthcare provider before receiving Corticotropin Injection if you have undergone or about to undergo any surgery.
What are some of the long-term side effects of Corticotropin Injection?
Prolonged use of Corticotropin Injection leads to long-term side effects such as Cushingâs syndrome, adrenal suppression, immune system suppression, electrolyte imbalances and psychiatric disturbances.
When should you report to your physician?
Tell your healthcare provider immediately if you experience any reactions like puffiness of face, weakness, menstrual changes, skin problems and mood changes.
How to store Corticotropin Injection?
Store Corticotropin Injection in a refrigerator without freezing, away from the reach of children.
How is Corticotropin Injection administered?
Corticotropin Injection is injected into your skin subcutaneously or into your muscle. Take this medicine only under the supervision of a qualified healthcare professional.
What precautions should you follow during this treatment?
Avoid consuming carbonated beverages, fruit juices and alcohol while on treatment with Corticotropin.
Who should not receive Corticotropin injection?
Corticotropin is not recommended for people with active infection, acute critical illness, heart failure, diabetes, hypersensitivity, hypothyroidism, uncontrolled hypertension, scleroderma.