DESIDUSTAT
Background and Date of Approval
Desidustat is an erythropoiesis-stimulating agent belonging to the hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) inhibitor medication class.
Uses
Desidustat is used to treat anemia in patients with chronic kidney disease by stimulating the production of red blood cells.
How is it administered?
Take the Desidustat as your physician advises. Take medicine at a fixed time. Do not crush, chew, or open the medicine. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Only stop taking the tablet if your doctor advises you to stop.
Side Effects
The most common side effects of Desidustat are vomiting, abdominal pain, fever, headache, weakness, and peripheral edema (accumulation of fluid).
Warnings
Do not consume Desidustat if you are allergic to Desidustat or any of its ingredients in the medication. Before starting the treatment, inform your doctor if you have a history of seizures, strokes, or blood disorders (sickle cell anemia). Always check the expiry date before consuming the medicine.
Precautions
Notify your doctor if you are pregnant, planning to get pregnant, or think you may be pregnant or breastfeeding. Before taking Desidustat, inform your doctor if you are pregnant, planning to get pregnant, or think you may be pregnant or are breastfeeding. Your iron levels and blood pressure will be regularly monitored before and during the treatment. It is unknown whether Desidustat alters driving ability. However, if you experience side effects like tiredness or drowsiness, avoid driving and using machines.
Word of Advice
Before starting treatment, inform your doctor of all underlying medical conditions you have. Do not discontinue the medicine without your doctor's advice. Do not take a double dose to compensate for a missed dose. Notify your doctor if you experience any serious side effects. Contact your doctor for further information.
References
Clinicaltrials.gov, NCT04012957, [Revised on 24th Nov 2021] [Accessed on 27th June 2023], https://clinicaltrials.gov/ct2/show/NCT04012957 J. Goddard, A.N. Turner, Kidney and Urinary Tract Disease, Davidsonâs Principles and Practice of Medicine, 22nd Edition, 2014, 461-523. Amit A Joharapurkar et al., Prolyl Hydroxylase Inhibitors: A Breakthrough in the Therapy of Anemia Associated with Chronic Diseases, J. Med. Chem. 2018, 61, 16, 6964â6982, https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.7b01686
Frequently Asked Questions
How to manage the side effects of Desidustat?
To manage the side effects of Desidustat, follow the prescribed dosage, and report side effects promptly. Stay hydrated, and monitor blood pressure regularly. Maintain a healthy lifestyle by following a balanced diet and attending follow-up appointments.
Can children use Desidustat?
It is unknown whether the medicine is safe to use in children. Consult a healthcare professional for more details about using Desidustat in children. The suitability of any medication depends on factors such as age, weight, and specific medical conditions.
Can Desidustat be taken during pregnancy or while breastfeeding?
Information regarding the usage of Desidustat during pregnancy and breastfeeding is unknown. So, it is recommended to get healthcare professionals' advice before consuming the medicine. The potential benefits and risks of the medicine should be carefully assessed.
What should I do if I miss a dose of Desidustat?
If you miss a tablet dose, take it as soon as possible. However, if it's close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose of Desidustat.
What are the side effects of Desidustat?
Common side effects of Desidustat include vomiting, abdominal pain, fever, headache, weakness, and peripheral edema (accumulation of fluid). It is crucial to consult your doctor for any concerns or persistent side effects.