DOMPERIDONE,RABEPRAZOLE
Background and Date of Approval
Domperidone and rabeprazole is a combination of antiulcer medications approved by the U.S. Food and Drug Administration for treatment of gastroesophageal reflux disease and peptic ulcer disease. The combination also assists in management of nausea and vomiting.
Uses
Domperidone, Rabeprazole helps to treats conditions such as gastroesophageal reflux disease (in which the stomach acid and contents flow back into the esophagus), peptic ulcers (a sore or erosion that forms on the stomach lining), and nausea and vomiting.
How is it administered?
Take the Domperidone and Rabeprazole Tablet as your physician advises. Usually, the tablets will be taken with a glass of water. Do not crush, chew, or open the medicine. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Only stop taking the tablet if your doctor advises you to stop.
Side Effects
The side effects known to occur commonly during the treatment with Domperidone, Rabeprazole are headache, stomach pain, diarrhea, dryness in the mouth, weakness, nausea, vomiting, infection, rash, itching, painful or tender breasts and back pain.
Warnings
This medicine is contraindicated in people with a history of cardiac arrhythmias such as ventricular fibrillation, ventricular tachycardia, or QT prolongation or in those taking medications that prolong the QT interval. This tablet may cause side effects such as dizziness, drowsiness, or vision changes in some individuals. If these effects occur, avoiding activities requiring alertness, such as driving, cycling, or operating machinery, is important until you feel better.
Precautions
Long-term use of this medicine may result in low magnesium levels in the body (hypomagnesemia). Symptoms of low magnesium levels include fatigue, muscle spasms or weakness, irregular heartbeat, and seizures. If you develop any of these symptoms, notify your doctor immediately. It is necessary to discuss using Domperidone and Rabeprazole with your physician if you are pregnant, suspecting pregnancy, or breastfeeding.
Word of Advice
Take Domperidone and Rabeprazole tablets as prescribed by your doctor. Do not alter the dose or discontinue the medication without consulting your doctor first. This medicine is typically taken at least one hour before meals. Follow your doctor's specific instructions regarding timing and dosing. Dietary modifications may support your treatment while taking this medicine. Avoid foods and beverages that trigger your symptoms, including spicy or acidic foods, caffeine, and alcohol. Eat smaller meals and avoid eating close to bedtime. Consider elevating the head of your bed to help reduce nighttime acid reflux.
References
Rabicip D Capsules; Ciplamed; Accessed on 02/06/2023; https://www.ciplamed.com/content/rabicip-d-capsules Savita Shahani, Prabha Sawant, Pareen Dabholkar; Rabeprazole plus Domperidone: the answer for gastro-oesophageal reflux disease; Journal of the Indian Medical Association; Published on April 2008; Accessed on 02/06/2023; https://pubmed.ncbi.nlm.nih.gov/18828350/ Goodman & Gilman's, The Pharmacological Basis of Therapeutics, Pharmacotherapy of acidity, ulcer, and reflux disease, 12th edition, 2011, 1319.
Frequently Asked Questions
Are there any dietary restrictions or considerations while on Domperidone and Rabeprazole?
While there are no specific dietary restrictions associated with Domperidone and Rabeprazole following a healthy diet and lifestyle modifications is generally recommended to support gastrointestinal health.
Whether Domperidone and Rabeprazole can be taken for heartburn relief?
Yes, Domperidone and Rabeprazole can relieve heartburn, especially when associated with gastroesophageal reflux disease (GERD) or peptic ulcer.
How does the combination of Domperidone and Rabeprazole work?
The medications target both the overproduction of stomach acid and impaired gastrointestinal motility, addressing multiple aspects of the underlying causes of GERD. This combination can provide complete relief and help improve digestive health.
What are the common side effects of Domperidone and Rabeprazole?
Common side effects of Domperidone and Rabeprazole may include nausea, vomiting, infection, rash, itching, painful or tender breasts, and back pain. These side effects are usually temporary and set back to normal as the medication is eliminated.
Whether Domperidone and Rabeprazole affect kidneys?
This drug is generally considered safe for the kidneys. It is metabolized in the liver and mainly excreted through the bile. The kidneys play a minimal role in eliminating this drug from the body.