DUTASTERIDE,SILODOSIN

Dutasteride and silodosin are indicated for the treatment of benign prostatic hyperplasia (BPH) in men. Dutasteride belongs to the class of 5-alpha reductase inhibitors, while silodosin is an alpha-1 blocker.

Dutasteride + Silodosin treats benign prostatic hyperplasia (BPH) in men with an enlarged prostate. Taking this medication can help to reduce the problems like difficulty in urination, frequent urination, and other related symptoms.

Take the Dutasteride + Silodosin as your physician advises. Usually, the tablets will be taken with or without food. Do not crush, chew, or open the medicine. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Only stop taking the tablet if your doctor advises you to stop.

The most common side effects of Dutasteride + Silodosin are skin rash, hives, and swelling of the face, eyelids, lips, arms, or legs. Serious side effects while taking Dutasteride + Silodosin are low sperm count and movement, low sex drive, impotence, and enlarged or painful breasts.

Dutasteride + Silodosin should not be consumed if you are allergic to Dutasteride, Silodosin, or any of its ingredients in the medication. Do not consume this medicine if you have severe liver or kidney problems. Notify your doctor if you have heart disease or if you notice breast lumps or nipple discharge. This medicine is specifically for men and should not be taken by women or children. Pregnant women or those who could become pregnant should not handle the medication if it leaks, as it can harm the baby. If there is any contact, wash the area with soap and water immediately. Do not consume alcohol while taking this medicine.

It is advised to use contraceptives to avoid the transfer of semen. Inform your doctor if you are taking this medicine during a PSA test because it can affect PSA blood tests for detecting prostate cancer. Patients should be cautious about driving and operating machinery while taking Dutasteride + Silodosin. Contact your doctor for more information.

Before prescribing Dutasteride + Silodosin, your healthcare provider will evaluate for prostate conditions, including cancer. Inform your doctor if you are planning cataract surgery and about all existing medical conditions. Do not discontinue the medicine without your doctor's guidance. Do not take a double dose to compensate for a missed dose. Notify your doctor if you experience any serious adverse effects. Your healthcare provider will advise whether dose adjustments are required. Contact your doctor for additional information.

Kazuhisa Hagiwara et al., Efficacy and Safety of Silodosin and Dutasteride Combination Therapy in Acute Urinary Retention due to Benign Prostatic Hyperplasia: A Single-Arm Prospective Study, BioMed Research International, 2016, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852328/pdf/BMRI2016-4975851.pdf J. Goddard, A.N. Turner, Kidney and Urinary Tract Disease, Davidson’s Principles and Practice of Medicine, 22nd Edition, 2014, 461-523. Peter J. Snyder, Androgens and the Male Reproductive Tract, Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 13th Edition, 2018, 833-843. Rivopharm UK Ltd, Electronic Medicines Compendium (EMC), [Revised on March 2017] [Accessed on 23 June 2023], *Microsoft Word - uk-pl-clean (medicines.org.uk) Dailymed, [Accessed on 23 June 2023], DailyMed - SILODOSIN capsule (nih.gov)