ESOMEPRAZOLE,LEVOSULPIRIDE
Background and Date of Approval
Esomeprazole with levosulpiride is an approved combination medication used to treat gastroesophageal reflux disease in patients.
Uses
Esomeprazole, a proton pump inhibitor, reduces stomach acid, relieving heartburn symptoms and promoting esophageal healing. Levosulpiride, an antipsychotic and prokinetic agent, affects dopamine receptors. Together, they lower acid production, aiding healing and preventing damage in the esophagus.
How is it administered?
Esomeprazole+levosulpiride is available as tablets and capsules for oral intake. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition.
Side Effects
The side effects known to occur commonly during the treatment with esomeprazole+levosulpiride are headache, stomach pain, accumulation of gas, nausea, vomiting, constipation, diarrhea and benign polyps in the stomach (masses of cells form in the stomach lining).
Warnings
If you have known allergies to this drug or its components, it is not suitable for you. Using Esomeprazole+levosulpiride may worsen your urinary retention, making it difficult to empty your bladder. Be cautious if you have this issue, and if urinary retention happens, your doctor might consider stopping the treatment. Make sure to tell your doctor about any kidney or liver problems you have. They might give you a low dose and conduct regular blood tests to monitor your condition.
Precautions
It is generally recommended to avoid using esomeprazole+levosulpiride during pregnancy unless it is necessary. Taking this drug while breastfeeding is unsafe because it may affect the child. Do not breastfeed while taking this medicine. This tablet does contain lactose, and if you have been diagnosed with a rare hereditary problem of galactose intolerance, glucose-galactose malabsorption, or Lapp lactase deficiency, it is advised not to use this medication.
Word of Advice
Take esomeprazole and levosulpiride tablets exactly as prescribed by your doctor. Do not alter the dose or discontinue the medication without consulting your doctor first. This combination is usually taken at least one hour before meals. Follow your doctor's instructions regarding timing and dosing of the medication. Certain dietary modifications may support your treatment while taking this medicine. Avoid foods and beverages that trigger your symptoms, including spicy or acidic foods, caffeine, and alcohol. Eat smaller meals and avoid eating close to bedtime. Elevating the head of your bed may help reduce nighttime acid reflux.
References
Soigner Pharma, Manufacturer, [Accessed on 07 Oct 2023], https://www.soignerpharma.com/product/esperam-ls/ La Renon Healthcare Pvt Ltd., [Revised on 2018] [ Accessed on 07 Oct 2023], https://www.larenon.com/wp-content/uploads/2018/10/ESOGRESS.pdf I.D. Penman, C.W. Lees, Alimentary tract and pancreatic disease, Davidsonâs Principles & Practice of Medicine, 22nd Edition, 2014, 837-920.
Frequently Asked Questions
Are there any dietary restrictions or considerations while on esomeprazole+levosulpiride?
While there are no specific dietary restrictions associated with esomeprazole+levosulpiride, following a healthy diet and lifestyle modifications is generally recommended to support gastrointestinal health.
Whether esomeprazole+levosulpiride can be taken for heartburn relief?
Yes, Esomeprazole+levosulpiride can relieve heartburn, especially when associated with gastroesophageal reflux disease (GERD) or peptic ulcer.
How does the combination of esomeprazole+levosulpiride work?
The medications target both the overproduction of stomach acid and impaired gastrointestinal motility, addressing multiple aspects of the underlying causes of GERD. This combination can provide complete relief and help improve digestive health.
What are the common side effects of esomeprazole+levosulpiride?
Common side effects of esomeprazole+levosulpiride may include nausea, vomiting, infection, rash, itching, painful or tender breasts, and back pain. These side effects are usually temporary and set back to normal as the medication is eliminated.
Whether esomeprazole+levosulpiride affect kidneys?
This drug is generally considered safe for the kidneys. It is metabolized in the liver and mainly excreted through the bile. The kidneys play a minimal role in eliminating this drug from the body.