HISTAMINE DIHYDROCHLORIDE,HUMAN NORMAL IMMUNOGLOBULIN,SODIUM THIOSULPHATE

Histamine Dihydrochloride + Human Normal Immunoglobulin + Sodium Thiosulphate is a combination medicine approved for treatment and prevention of various allergic conditions, including generalised skin allergies, eczema, and allergic rhinitis.

It is used to treat Eczema, urticaria, migraine headaches, premenstrual syndrome (PMS) and provides relief from respiratory distress and rhinitis.

It is available in injection form of dose 1 ml administered subcutaneously containing the composition in ratio of human normal immunoglobulin 12 mg, histamine dihydrochloride 0.15 mcg, sodium thiosulphate 32mg. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition.

Histamine dihydrochloride + human normal immunoglobulin + sodium thiosulphate can cause side effects like any other medicine. Sometimes it may cause some serious side effects that include severe allergic reactions, muscle weakness or paralysis, severe pain or swelling at the injection site and even blood clots commonly, people may experience injection site reactions, fever, nausea and vomiting, diarrhea, dizziness and fatigue.

Avoid Histamine + Dihydrochloride + Human normal immunoglobulin + Sodium thiosulphate if allergic to any of its components. Consult your physician if you have an allergy or superinfection; these conditions should be addressed before beginning this injectable therapy. Because this injection is a thermolabile medication, it should only be used with a cool syringe. It needs to be applied subcutaneously.

Due to limited data on its safety during pregnancy and breastfeeding, this medication is generally not recommended in these situations. This medication is ineffective during an acute allergic attack, such as anaphylaxis. Discuss with your doctor if you have any underlying medical conditions like severe kidney or liver disease, as they might need special considerations when using it. It can be used safely in children under proper medical supervision.

Live vaccines should be avoided during treatment with histamine dihydrochloride, human normal immunoglobulin, and sodium thiosulphate, or within a certain period after administration. Immunoglobulin products may interfere with the effectiveness of live vaccines; timing of vaccinations should be discussed with your healthcare provider.

Inform your healthcare provider of any existing medical conditions, particularly those involving kidney impairment, blood clotting disorders, or a history of thrombosis. Patients with infection concerns should discuss these with their healthcare provider.

Notify your doctor of all medications, supplements, and herbal products being taken, as these may interact with this medication and affect its efficacy or cause adverse reactions.

Report any adverse reactions or unexpected symptoms occurring after administration to your healthcare provider without delay.

Bharat Serums and Vaccines Limited, [Accessed on 28th Dec 2023], https://www.bharatserums.com/assets/pdf/products/Histoglob.pdf Dr.Surya Mangadevi. Thota, Efficacy of Injection Histoglob in Treatment of Chronic Urticaria-A Prospective Study, IOSR Journal of Dental and Medical Sciences, 2019, 18(3), 57-62, https://www.iosrjournals.org/iosr-jdms/papers/Vol18-issue3/Series-8/L1803085762.pdf Bertram G. Katzung, Histamine, Serotonin & the Ergot Alkaloids, Lange’s Basic & Clinical Pharmacology, 14th Edition, 2018, 277-299.