INFLIXIMAB
Background and Date of Approval
Infliximab is an antirheumatic drug developed by the U.S. Food And Drug Administration and initially approved in 1998 for treating Rheumatoid arthritis.
Uses
Infliximab is used to treat various inflammatory conditions, primarily autoimmune diseases like rheumatoid arthritis, Crohn's disease, ulcerative colitis, ankylosing spondylitis, psoriatic arthritis, and psoriasis.
How is it administered?
Infliximab can be administered only as an intravenous injection into a vein by your physician in a hospital setting. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition.
Side Effects
The side effects known to occur commonly during the treatment with Infliximab are upper respiratory infections, injection site reactions, headache, dizziness, stomach pain, pain in joints, muscles or back, difficulty breathing, chest pain, diarrhea, constipation, indigestion, heartburn, bruising, flushing, nosebleed, feeling tired, depression, difficulty sleeping, eye problems, fast heartbeat, hair loss, tingling sensation or numbness. Some serious side effects include serious infections (TB, blood infections, fungal infections), low blood counts, and possible signs of cancer (weight loss, fever, changes in moles or skin coloring, unusual vaginal bleeding).
Warnings
If you are allergic to Infliximab or any other ingredients, you should not use this medication. Individuals who are allergic (hypersensitive) to proteins that come from mice should not receive this drug. If you have active tuberculosis (TB) or another severe infection like pneumonia or sepsis, this drug should not be used, as it may weaken the immune system and exacerbate these infections.
Precautions
Notify your doctor if you are pregnant or planning to get pregnant before taking Infliximab. It will be given only if needed. If you received this medicine while you are pregnant, inform your babyâs physician before your baby is given any vaccine. Before you start breastfeeding, your last treatment must be at least six months ago. Consult your doctor if you are breastfeeding before taking this medicine.
Word of Advice
Diarrhea can lead to dehydration and fluid loss. It's necessary to drink plenty of fluids, such as water, oral rehydration solutions, or clear broths when using Infliximab to address diarrhea. Proper hydration helps replace lost fluids and electrolytes and supports the body's recovery.
References
Janssen Biologics BV, Electronic medicines compendium (EMC), [Revised on Oct 2020] [Accessed on 27th Sep 2023], https://www.medicines.org.uk/emc/files/pil.3831.pdf Janssen Biotech, US Food and Drug Administration, [Revised on Nov 2013] [ Accessed on 27th Sep 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/103772s5359lbl.pdf Goodman & Gilmanâs, The Pharmacological Basis of Therapeutics, Immunosuppressants, tolerogens, and immunostimulants, 12th edition, 2011, 1018.
Frequently Asked Questions
Who should not take Infliximab?
Infliximab may not be suitable for everyone. People with active infections, a history of certain neurological conditions, congestive heart failure, or a known allergy to the drug or any of its components should not take this medication. It is crucial to discuss your medical history and current medications with your healthcare provider before starting the treatment.
How is Infliximab administered?
Infliximab is typically administered as an intravenous (IV) infusion. It is usually given in a healthcare facility like a hospital or infusion center. The frequency of infusions and the dosage can vary depending on the condition being treated.
Is Infliximab available over-the-counter (OTC)?
Infliximab is available by prescription and is not commonly found as an over-the-counter (OTC) medication. It is important to consult with a physician for an accurate diagnosis and prescription.
How long does it take for Infliximab to start working?
The time it takes for Infliximab to start working varies from person to person and depends on the condition being treated. Some individuals may experience relief within a few weeks, while others may need several months of treatment to see significant improvement.
Can I receive vaccines while on Infliximab?
It's essential to discuss vaccinations with your healthcare provider while on Infliximab. Some live vaccines should be avoided, but many non-live vaccines are recommended for individuals on immunosuppressive medications to prevent infections.