IVOSIDENIB
Background and Date of Approval
Ivosidenib is a targeted therapy for cancers with a specific genetic mutation in the IDH1 enzyme. United States (US FDA): Approved in July 2018 for relapsed/refractory acute myeloid leukaemia (AML). Expanded approvals for newly diagnosed AML and cholangiocarcinoma.
Uses
IVOSIDENIB tablet is used to treat: Acute myeloid leukaemia (AML) with an IDH1 mutation. Cholangiocarcinoma (bile duct cancer) with an IDH1 mutation.
Side Effects
Like all medicines, IVOSIDENIB may cause side effects, although not everyone experiences them. Common Side Effects Fatigue Joint pain Diarrhoea Nausea or vomiting Loss of appetite Abdominal pain Fever Shortness of breath Rare but Serious Side Effects Irregular heartbeat Severe swelling or weight gain Differentiation syndrome (fever, breathing problems, fluid build-up) Severe dizziness Liver problems Contact your doctor immediately if any serious side effects occur.
Warnings
Differentiation syndrome can be life-threatening if untreated. Heart rhythm changes require ECG monitoring. Monitor blood counts regularly.
Precautions
Inform your doctor about heart conditions. Avoid drugs that prolong the QT interval. Regular blood tests are required. Use contraception during treatment.
References
https://www.IVOSIDENIB.com/ https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/211192_s008lbl.pdf https://www.news-medical.net/drugs/IVOSIDENIB.aspx
Frequently Asked Questions
What is IVOSIDENIB used for?
IVOSIDENIB is used to treat acute myeloid leukaemia (AML) and cholangiocarcinoma that contain a mutation in the IDH1 gene.
How does IVOSIDENIB work?
IVOSIDENIB works by blocking the mutated IDH1 enzyme that helps cancer cells grow, thereby slowing or stopping cancer progression.
Can IVOSIDENIB cause serious side effects?
Yes. Some patients may experience serious effects such as heart rhythm problems or differentiation syndrome. Immediate medical attention is required if symptoms appear.
Can I stop taking IVOSIDENIB if I feel better?
No. Continue taking the medicine exactly as prescribed by your doctor unless advised otherwise.
How long will I need to take IVOSIDENIB?
The duration of treatment depends on your condition and response to therapy, and your doctor will determine the treatment plan.