KETOCONAZOLE AND ZINC PYRITHIONE
Background and Date of Approval
Ketoconazole and Zinc Pyrithione are antifungal agents used in combination and belong to the therapeutic class of dermatological medications.
Uses
Ketoconazole + Zinc pyrithione is used to treat and prevent scalp conditions such as dandruff, seborrheic dermatitis, tinea capitis (scalp ringworm), and other scalp infections caused by yeast or bacteria. It is also used to prevent the recurrence of dandruff and seborrheic dermatitis and to promote healthy scalp and hair growth.
How is it administered?
Ketoconazole + Zinc pyrithione is typically administered topically. The best route of administration depends on the individual's needs and preferences.
Side Effects
Ketoconazole + Zinc pyrithione can cause side effects in some people. The most common side effects are mild and temporary, such as scalp irritation, dryness, itching, burning, and hair loss. Serious side effects are rare but may include allergic reactions, contact dermatitis, severe redness and irritation, and skin peeling or blistering.
Warnings
Ketoconazole + Zinc pyrithione can cause allergic reactions in some people. Symptoms of an allergic reaction may include hives, difficulty breathing, and swelling of the face, throat, or tongue. This medication can also cause contact dermatitis, a type of skin irritation. Symptoms of contact dermatitis may include redness, itching, and burning on the scalp.
Precautions
Stop and seek medical attention immediately if you experience allergic reactions after using Ketoconazole + Zinc pyrithione. If you experience symptoms like redness, itching, and burning on the scalp after using it, stop using it and talk to your doctor.
Word of Advice
Avoid contact with eyes, nose, and mouth during use of Ketoconazole + Zinc pyrithione. If the medication enters your eyes, rinse immediately with water. Do not apply to open wounds or cuts on the scalp until healing is complete. Keep away from open flames and heat sources. Use as directed by your doctor or pharmacist. Do not exceed the directed dose. If irritation or other side effects occur during use, discontinue and consult your doctor. Inform your doctor of all other medications before using this product. If using other hair products such as conditioners or styling products, rinse them thoroughly before applying this medication. If you have other scalp conditions such as psoriasis or eczema, consult your doctor before use.
References
Minji Park et al., Understanding the Mechanism of action of the Anti-dandruff agent Zinc Pyrithione against Malassezia Restricta, Scientific Reports, 2018, [Accessed on 17th Oct 2023] http://www.bktimes.net/data/board_notice/1534842545-66.pdf KD Tripathi, Antifungal Drugs, Essentials of Medical Pharmacology, 8th Edition, 2019, 838-848. Suresh Sadhasivam et al., Newly Developed Anti-Dandruff Regimen, VB-3222, Delivers Enhanced Sensorial and Effective Therapeutic Benefits Against Moderate Adherent Dandruff, Clin Cosmet Investig Dermatol. 2020; 13: 187â195, [Accessed on 17th Oct 2023], https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041436/pdf/ccid-13-187.pdf
Frequently Asked Questions
How do I use Ketoconazole, Zinc pyrithione?
To use Ketoconazole, Zinc pyrithione, wet your hair thoroughly and apply a generous amount of shampoo to your scalp. Massage the shampoo into your scalp for 2-3 minutes, then rinse thoroughly. It can be used once or twice weekly or as your doctor directs.
What are the side effects of Ketoconazole, Zinc pyrithione?
The most common side effects of Ketoconazole + Zinc pyrithione are mild and temporary and go away on their own. These side effects may include scalp irritation, dryness, itching, burning, and hair loss. Serious side effects of this medication are rare but may include allergic reactions, contact dermatitis, severe redness and irritation, and skin peeling or blistering.
How long should I use Ketoconazole, Zinc pyrithione?
You should use Ketoconazole, Zinc pyrithione for as long as your doctor recommends. For some people, this may be just a few weeks, while others may need to use it for longer periods.
Will Ketoconazole, Zinc pyrithione stain my hair?
Ketoconazole, Zinc pyrithione is not known to stain hair. However, it is important to note that all hair is different, and it is always possible for a product to stain hair, even if it is not known to do so. If you are concerned about staining, testing the medication on a small section of your hair before using it on your entire head is always a good idea.
Can I use Ketoconazole, Zinc pyrithione every day?
Ketoconazole, Zinc pyrithione is not intended for daily use. It is generally recommended to use it once or twice a week or as directed by your doctor. Using it more often than recommended can increase the risk of side effects, such as scalp irritation and dryness.
Is Ketoconazole, Zinc pyrithione available over the counter?
Yes, Ketoconazole, Zinc pyrithione is available over the counter in most pharmacies. However, it is always a good idea to talk to your doctor before using any new medication, over the counter or prescription.