L-ARGININE,PROANTHOCYANIDIN

Background and Date of Approval

L-arginine and proanthocyanidin granules combination is approved for medical use as dietary supplements in India.

Uses

L-arginine + proanthocyanidin granules are a combination of vital nutrients, particularly for pregnant women, as they promote the growth and development of both the baby and the mother. These granules have diverse health benefits and are used to manage nutritional deficiencies, heart disease, high blood pressure, and enhanced blood sugar levels related to diabetes. They also aid in treating erectile dysfunction and enhancing athletic performance. Specifically designed to enhance blood supply to the placenta and fetus, these supplements are given to pregnant women at risk of conditions like pre-eclampsia (high blood pressure and high protein in urine during pregnancy) and intrauterine growth restriction (IUGR), which hampers normal fetal weight gain during pregnancy.

How is it administered?

L-arginine + proanthocyanidin granules combination is available as a 6.5gm sachet for oral intake directed by a physician. Your doage and duration will be determined by your healthcare provider based on the severity of your condition.

Side Effects

L-arginine + proanthocyanidin granules supplement is generally safe to consume and is not associated with significant side effects. However, consult your physician for more advice if you experience any unfamiliar side effects.

Warnings

Individuals with guanidinoacetate methyltransferase deficiency (GAMT) should avoid this supplement due to their inability to convert arginine and related compounds into creatine, which might lead to complications. Before using this medication, inform your doctor if you have a medical history of kidney or heart disease. Additionally, it is crucial to know that L-Arginine + Proanthocyanidins Sachets may interfere with blood pressure regulation during and after surgery. To avoid complications, it is advised to stop these supplements at least two weeks before any scheduled surgery is advised, following consultation with a healthcare professional.

Precautions

It is crucial to notify your doctor before using L-arginine + proanthocyanidin supplements during pregnancy. Limited information exists about their safety for breastfeeding mothers and individuals with liver or lung conditions. The compatibility with alcohol consumption is uncertain. If you experience dizziness, it's advisable to refrain from driving and consult your doctor promptly for guidance.

Word of Advice

Before starting L-arginine + proanthocyanidin, consult your doctor, particularly if you have pre-existing health conditions or are taking other medications. Start with a low dose and increase gradually as tolerated. Adhere to the prescribed daily limit. Monitor for potential side effects and discontinue immediately if adverse reactions occur. Your doctor will provide guidance appropriate to your individual health status. Your physician may recommend regular kidney function tests and electrolyte monitoring, as L-arginine in L-arginine + proanthocyanidin may increase potassium levels in patients with kidney disease. Maintain optimal health through a balanced diet containing whole grains, vegetables, and fruits. Avoid smoking and excessive alcohol. Maintain a healthy body weight through nutritious eating and regular exercise. Include calcium and magnesium-rich foods such as prunes, raisins, and orange juice in your diet. Choose low-fat dairy options including yogurt, milk, and cheese. Replace unhealthy snacks with nutritious alternatives such as unsalted nuts and frozen yogurt. Be aware of hidden fats in processed foods like chips and pastries; instead, use cooking oils rich in omega-3 fatty acids. These lifestyle modifications can substantially improve your overall well-being.

References

Biobricpharma, Manufacturer; [Accessed on 20th Oct 20223] https://www.biobrickpharma.com/product/l-arginine-proanthocyanidin/ Kiani AK, et al., Dietary supplements for improving nitric-oxide synthesis; J Prev Med Hyg, Published on Oct 2022; Accessed on 20/10/2023; https://pubmed.ncbi.nlm.nih.gov/36479475/ Xie Y, et al., Proanthocyanidins: A novel approach to Henoch‑Schonlein purpura through balancing immunity and arresting oxidative stress via signaling pathway (Review); Exp Ther Med; Published on May 2023; Accessed on 20/10/2023; https://pubmed.ncbi.nlm.nih.gov/37229322/

Frequently Asked Questions

How long should I take L-arginine + proanthocyanidin?

You should take L-arginine + proanthocyanidin for as long as your physician suggests. However, if the adverse effects persist or worsen, please consult your doctor.

Does L-arginine + proanthocyanidin cause high potassium levels (hyperkalemia) in my body?

L-arginine + proanthocyanidin contains L-arginine, which may increase the potassium level in the body, leading to hyperkalemia. So, if you have a high potassium level, inform your doctor about this before taking the L-arginine + proanthocyanidin.

Is L-arginine + proanthocyanidin supplement affect the kidney?

L-arginine within this supplement is excreted by the kidneys, and high levels of L-arginine can harm the kidneys. Hence, L-arginine + proanthocyanidin supplement is used with caution in kidney patients. Inform your doctor if you have any kidney problems before taking this supplement.

Should I stop taking L-Arginine + proanthocyanidins Sachets before my surgery?

Yes, L-arginine + proanthocyanidins supplement may interfere with blood pressure regulation during and after surgery. To avoid complications, it is advised to stop these supplements at least two weeks before any scheduled surgery, following consultation with a healthcare professional.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS