LIDOCAINE 1.5%,NIFEDIPINE 0.3%

Lidocaine 1.5% combined with nifedipine 0.3% is approved for medical use in the treatment of anal fissure.

Lidocaine 1.5% + nifedipine 0.3% combination cream is used in the treatment of anal fissures with a fast healing response. Anal fissures are tears in the lining of the anal canal, often caused by constipation and the passing of hard faces. These create spasms that reduce blood flow, preventing the healing of fissures. It also prevents the evolution of acute anal fissure to chronic anal fissure.

Lidocaine + nifedipine combination is available in the concentration of each 1.5% and 0.5%, respectively, as a topical cream for external use to be applied on the anal passage as directed by a physician.

Serious side effects of lidocaine 1.5% + nifedipine 0.3% may include severe allergic reactions such as rashes, swelling, difficulty breathing, and severe dizziness. Common side effects include irritation in the rectal area.

Before using this cream, inform your doctor if you have allergies to lignocaine or nifedipine. Also, inform your doctor if you have any underlying disease before using this cream. Give a detailed account of your medical history and medications to your healthcare provider to ensure safe usage of lidocaine 1.5% + nifedipine 0.3% cream.

Lidocaine 1.5% + nifedipine 0.3% is designed exclusively for external use only. Use the cream exactly as directed by your doctor. Avoid contact with your eyes. Prompt immediately if you notice any adverse reaction to this cream.

Lidocaine 1.5% + nifedipine 0.3% cream is for topical application in the anal passage only. Use the provided applicator to insert a measured dose of the cream into the anal canal. Avoid contact with eyes, mouth, or nose. If contact occurs, rinse the affected area with cold water immediately. To manage constipation associated with anal fissures, maintain adequate hydration by drinking sufficient fluids. Include fibre-rich foods such as whole grains, oatmeal, and citrus fruits in your diet. Regular exercise is beneficial, and prolonged time sitting on the toilet should be avoided. Respond promptly to the urge to defecate and do not delay, to support effective treatment and symptom relief.

Perrotti P et al., Topical nifedipine with lidocaine ointment vs. active control for treatment of chronic anal fissure: results of a prospective, randomized, double-blind study; Published on Nov 2022; Accessed on 03/11/2023; https://pubmed.ncbi.nlm.nih.gov/12432293/ Albayati RK et al; Topical combination of Nifedipine with Lidocaine for Anal Fissure Treatment; Indian Journal of Public Health Research and Development; Published on Feb 2019; Accessed date 03/11/2023; https://www.researchgate.net/publication/331625528_Topical_Combination_of_Nifedipine_with_Lidocaine_for_Anal_Fissure_Treatment Katsinelos P et al., Aggressive treatment of acute anal fissure with 0.5% nifedipine ointment prevents its evolution to chronicity; World J Gastroenterol; Published on Oct 2006; Accessed on 03/11/2023; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4088118/ Michigan Medicine, the U.S Food and Drug Administration (FDA); [Revised on March 2017] [Accessed on Nov 2023]; http://www.med.umich.edu/1libr/MBCP/NifedipineOintment.pdf KD Tripathi, Essentials of Medical Pharmacology, Antianginal and other anti-ischaemic drugs, 7th edition, 2013, 547-549. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Local Anaesthetics, 12th edition, 2011, 572- 573.