MEASLES MUMPS,RUBELLA VACCINE

Background and Date of Approval

The Measles, Mumps, and Rubella vaccine is a combination vaccine that protects against three infectious diseases: measles, mumps, and rubella. It is a routine childhood vaccination in many countries, including the United States. Measles is a highly contagious viral infection that can cause serious complications, including pneumonia, encephalitis (brain swelling), and even death. Mumps is a viral infection primarily affecting the salivary glands, causing swelling and pain in the jaw area. It can also lead to complications such as meningitis (inflammation of the brain layer), deafness, and inflammation of the testicles or ovaries. Rubella is a viral infection that causes a rash and fever. While it is generally a mild illness, it can have severe consequences if contracted by pregnant women, as it can lead to congenital rubella syndrome in the unborn child. The U.S. Food and Drug Administration (FDA) first licensed the vaccine in the United States in 1971.

Uses

The measles, Mumps, and Rubella vaccine prevents Measles, Mumps, and Rubella infection.

How is it administered?

A healthcare professional typically administers measles, Mumps, and Rubella vaccines. It is usually given as an injection. The healthcare provider will determine the dosage and duration of treatment based on the specific infection and individual factors.

Side Effects

Common side effects of the Measles, Mumps, and Rubella (MMR) vaccine include mild and temporary symptoms such as soreness, redness, or swelling at the injection site, low-grade fever, rash, temporary pain or stiffness in the joints, and mild swelling of the glands. Uncommon side effects may include seizures (associated with fever), temporary low platelet count, and temporary joint pain or stiffness.

Warnings

The Measles, Mumps, and Rubella (MMR) vaccine carries few warnings, but it is important to be aware of them. This vaccine can cause severe allergic reactions. It can cause harm to the developing fetus. This vaccine can result in Gullian Barre syndrome (severe neurological condition. While seizures following vaccination are rare, individuals with a history of seizures may have a slightly higher risk. Individuals with certain pre-existing medical conditions, such as moderate to severe acute illness, active tuberculosis, or untreated tuberculosis infection, may need to postpone receiving the MMR vaccine until the condition improves or is treated.

Precautions

Suppose an individual has had a severe allergic reaction (such as anaphylaxis) to a previous dose or any of its components. In that case, they should not receive further doses of the vaccine. People with severe immunodeficiency, such as certain types of cancer, HIV/AIDS with low CD4 counts (type of immune cell), or those receiving immunosuppressive treatments like chemotherapy or high-dose steroids, should not receive it. If an individual has received blood products or immunoglobulins (antibodies) within the past few months, the Measles, Mumps, and Rubella vaccine may need to be delayed. Pregnant women should not take it.

Word of Advice

Before receiving the Measles, Mumps, and Rubella vaccine, inform your healthcare provider about any known allergies, previous adverse reactions, or a history of seizures or Guillain-Barré Syndrome (neurological disease). Patients with severe immunodeficiency or those who have received blood transfusions or immune globulin within the past 11 months may require modified vaccination schedules. If a woman is planning to become pregnant, it is generally recommended to wait at least one month after receiving the vaccine before attempting to conceive. The vaccine vial stoppers or syringe caps may contain natural rubber latex, which can cause an allergic reaction in patients with latex allergies. If you or your child has a known latex allergy, it is important to inform your healthcare provider before receiving this injection. Discuss pre-existing medical conditions, recent treatments, and individual circumstances with your healthcare provider to determine the most appropriate approach to vaccination against Measles, Mumps, and Rubella.

References

Merck, Sharp & Dohme Corp, U.S FDA (Food Drug and Safety Administration), [Last Revised March 2023], [Accessed on 29th May 2023], https://www.fda.gov/media/75191/download Merck Sharp & Dohme (UK) Limited, Electronic medicine [Last Revised November 2022], [Accessed on 29th May 2023] https://www.medicines.org.uk/emc/files/pil.6307.pdf The Merck Manual, "Vaccines and Immunization, 19th Edition, 2018, 1080-1081

Frequently Asked Questions

Can the Measles, Mumps, and Rubella vaccine be given during an outbreak?

Vaccination with the Measles, Mumps, and Rubella vaccine is highly recommended during the measles, mumps, or rubella outbreak. It can help prevent further spread of the diseases and protect individuals who have not yet been vaccinated or are susceptible.

Is one Measles, Mumps, and Rubella vaccine enough for lifelong immunity?

For most individuals, two doses of the Measles, Mumps, and Rubella vaccine are recommended for long-lasting immunity. However, one dose provides significant protection; sometimes, one dose may be sufficient depending on the circumstances and individual immune response.

Can the Measles, Mumps, and Rubella vaccines be given simultaneously with other vaccines?

Yes, the Measles, Mumps, and Rubella vaccine can be given simultaneously as other vaccines. It is often administered as part of a combination vaccine. Administering multiple vaccines together reduces the required injections and ensures timely protection.

Can the Measles, Mumps, and Rubella vaccine cause infertility or reproductive problems?

No scientific evidence supports a link between the Measles, Mumps, and Rubella vaccine and infertility or reproductive problems. Multiple studies have shown no association between the vaccine and adverse effects on fertility or future pregnancies.

Can the Measles, Mumps, and Rubella vaccine overload a child's immune system?

No, the Measles, Mumps, and Rubella vaccine does not overload a child's immune system. Vaccines are designed to stimulate the immune system and protect against diseases. The immune response triggered by vaccines is well within the capacity of a healthy immune system to handle.

Can the Measles, Mumps, and Rubella vaccine be given to individuals with a weakened immune system due to medication or medical conditions?

Individuals with a weakened immune system should not receive live attenuated vaccines like the Measles, Mumps, and Rubella vaccine. However, recommendations may vary depending on the specific medical condition, treatment, and individual circumstances. It is crucial to consult with a healthcare provider for personalized advice.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS