METHOTREXATE

Methotrexate is an anti-metabolite and immunosuppressant medication. The FDA approved this for medical use on 26 February 1999.

It treats certain types of cancer, such as acute lymphocytic leukemia (ALL), meningeal leukemia, non-hodgkin’s lymphoma, osteosarcoma, cutaneous T-cell lymphoma, breast cancer, and head and neck cancer in adults. It is also used to treat severe psoriasis in adults (a skin disease in which red, scaly patches form on some body areas). It is also indicated to treat rheumatoid arthritis in adults.

Methotrexate is available as an injection and tablet. Always use this medicine as exactly prescribed by your doctor. Depending on the condition being treated, your physician decides the dose, dosage, and frequency of this injection. Methotrexate is injected into a vein (intravenously) or into muscle (intramuscularly). Do not self-administer this medicine. If you are prescribed with tablets, do not chew, crush or dissolve the tablets. The score line is only there to help you break the tablet if you have difficulty swallowing it whole. Swallow the tablets whole with water.

The common side effects of methotrexate are hair loss, photosensitivity, rash, diarrhea, nausea, vomiting, decreased WBC and platelet count, dizziness, tiredness, fever, and shivering, and blurred vision. Serious side effects of this medicine are severe allergic reactions, spitting or coughing blood, chest pain, weakness on one side of the body, and muscle weakness.

This drug is indicated to cause serious infections such as bacterial, fungal infections, hepatitis B reactivation, tuberculosis, and pneumonia. This medicine can cause neurotoxicity and increase your chances of developing secondary malignancies (tumors). Immunization with live vaccines is not recommended during the treatment because it can cause infections. This medicine can cause impairment of fertility in males and females. Discuss with your physician if you are trying for pregnancy.

Do not use this medicine if you are allergic to methotrexate or any of the other ingredients of this medicine. Do not take this medicine if you have kidney or liver problems, blood disorders, weakened immune system, pregnant, or breastfeeding. Inform your physician immediately if you experience any symptoms of spitting and coughing up blood, general muscle weakness, vision disturbance, changes in thinking, memory, and orientation problems. Avoid getting pregnant during the treatment and for six months after the last dose. Tell your doctor if you have a stomach ulcer, active infection, or mild kidney problems and about any recent vaccinations before starting the treatment. This medicine can cause serious side effects even with low doses; hence, regular follow-ups and routine laboratory tests will be necessary as a precaution. Inform your healthcare provider about all the medicines you take, including prescription, over-the-counter, vaccines, nutritional or vitamin supplements, and herbal products. Certain medications interact with methotrexate and reduce their effectiveness by causing undesirable side effects.

Store below 25°C. Do not freeze. Protect from light and excessive moisture. Keep out of reach of children and pets. If you miss a dose, take it as soon as you remember. However, skip the missed dose if the next scheduled dose is approaching. Avoid vaccination while using this medicine, as it increases infection risk. Methotrexate can cause photosensitivity; use sunscreen when outdoors. This drug affects fertility in both men and women; discuss with your doctor before starting treatment if this is a concern. Male patients with female partners of reproductive potential should use effective contraception during treatment and for 3 months after the final dose. Do not consume alcohol while receiving this medicine, as it may increase the risk of liver damage. This medicine may increase bleeding, bruising, and infection susceptibility. Take precautions to prevent illness and injury. Practise frequent hand hygiene. Your doctor will perform regular laboratory tests at follow-up visits to monitor the effects of this medicine. Attend all scheduled appointments. Inform your doctor if you develop sores or white patches on your lips, mouth, or throat during treatment with this medicine.

Methotrexate tablet - Patient Information Leaflet (PIL) - (emc) [Internet]. www.medicines.org.uk. [Revised March 2022] [cited 2023 Jun 2]. Available from: https://www.medicines.org.uk/emc/product/511/smpc Hospira, Methotrexate Tablet, Food and drug administration. acess.fda.gov. [Revised August 2020] [cited 2023 Jun 2]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/040054s015,s016,s017.pdf Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Pharmacotherapy of inflammatory bowel disease, 12th edition, 2011, 1358. KD Tripathi, Essentials of Medical Pharmacology, Antirheumatoid and antigout drugs, 7th edition, 2013, 211.