MIRABEGRON
Background and Date of Approval
Mirabegron is a beta-3 adrenergic receptor agonist used to treat overactive bladder (OAB). It works by relaxing the detrusor muscle during the bladder-filling phase, thereby increasing bladder capacity and helping to reduce symptoms such as urinary frequency and urgency. Unlike antimuscarinic medications, mirabegron acts through a different mechanism and has a different adverse-effect profile, with dry mouth and constipation generally being less characteristic.
Mirabegron was approved by the U.S. Food and Drug Administration (FDA) on June 28, 2012, for the treatment of OAB. It has subsequently been approved in several other countries and regions. Clinical trials demonstrated reductions in urinary frequency and episodes of urge urinary incontinence compared with placebo. Longer-term studies have provided additional data regarding its efficacy and safety. Mirabegron is generally well tolerated, although it can increase blood pressure, and blood-pressure monitoring is recommended, particularly in patients with hypertension.
Uses
Mirabegron treats symptoms associated with an overactive bladder, such as urgency incontinence (inability to control bladder emptying), sudden urination urges, and increased urinary frequency.
How is it administered?
Take the Mirabegron as your physician advises. Do not crush, chew, or open the medicine. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Only stop taking the tablet if your doctor advises you to stop.
Side Effects
The most common side effects of Mirabegron are increased heart rate, nausea, constipation, diarrhea, dizziness, and urinary tract infection Serious side effects while taking Mirabegron are irregular heartbeat, sudden or throbbing headache, angioedema (swelling of the face, mouth, or throat), elevated blood pressure.
Warnings
Mirabegron should not be taken if you have allergies to Mirabegron or if you have high uncontrolled blood pressure. Before starting the treatment, inform your doctor if you have trouble emptying your bladder (urinary retention) or if you are taking specific medications for HIV, fungal or bacterial infections, or anticholinergic medicine. Don't consume this medicine if you are pregnant or planning to get pregnant or breastfeeding.
Precautions
Notify your doctor if you have liver or kidney problems. Your doctor may adjust your dose in such conditions. Also, inform your doctor if you have any heart conditions, such as abnormal ECG (QT prolongation) or taking medications that may cause it. This medicine is not advised to use in children under 18 years old. Inform your doctor if you are pregnant, planning to get pregnant, or think you may be pregnant or breastfeeding.
Word of Advice
Patients with liver, heart, or kidney disease should use Mirabegron with caution and inform their doctor of all underlying medical conditions and concurrent medications. Do not discontinue the medicine without medical advice. If a dose is missed, do not take a double dose to compensate. Report any serious side effects to your doctor. Your doctor will determine whether dose adjustments are necessary. Store the medicine out of reach of children and pets. Do not freeze. Store below 30°C. Check the expiry date before use.
References
Astellas Pharma Ltd, Electronic Medicines Compendium (EMC), [Revised on December 2022] [Accessed on 6th June 2023], MIRABEGRON-TAB PL-Patient United Kingdom (Great Britain) en - TW366830 (medicines.org.uk) Astellas Pharma US, Inc; [Revised on March 2021] [Accessed on 6th June 2023], label (fda.gov) J. Goddard, A.N. Turner, Kidney and urinary tract disease, Davidsonâs Principles and Practice of Medicine, 22nd Edition, 2014, 461-523
Frequently Asked Questions
Is mirabegron an anticholinergic?
No! Mirabegron is not an anticholinergic medication. It is a beta-3 adrenergic agonist that relaxes the bladder muscles to improve urinary symptoms. Consult your healthcare provider for more information on medication classifications.
What is the best time of day to take Mirabegron?
The best time of day to take mirabegron can vary depending on the individual and healthcare provider's recommendation. It is generally recommended to follow the prescribed dosage instructions and take medicine at the same time each day for consistency.
What are the side effects of mirabegron?
Common side effects of mirabegron include increased blood pressure, headache, dizziness, urinary tract infection, and constipation. Contact your doctor if you experience any side effects, and consult your healthcare provider for more information.
How to manage the side effects of Mirabegron?
To manage the side effects of Mirabegron, follow your doctor's instructions, stay hydrated, and monitor blood pressure and any changes. Report severe side effects to your doctor and inform them about other medications or conditions. Maintain a healthy lifestyle and consult your doctor for personalized guidance.
Can you take Mirabegron when pregnant?
It is unsafe to consume this medicine while pregnant. Consult your medical professional regarding the use of Mirabegron during pregnancy. The potential benefits and risks should be carefully assessed. Your doctor will suggest taking this medicine only if it's necessary.
What should I do if I miss a dose of Mirabegron?
If you miss a capsule dose, take it as soon as possible. However, if it's close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose of Mirabegron.
Can mirabegron cause kidney damage?
If you have kidney disease, then your dose shouldn't be more than 25mg per day. Your doctor may advise you to lower your dose or stop taking Mirabegron. Please consult your doctor before taking this medicine.