PARACETAMOL/ACETAMINOPHEN
Background and Date of Approval
Paracetamol (acetaminophen) is an analgesic and antipyretic medication. It received FDA approval in 1951 for the treatment of pain and fever.
Uses
It is used to relieve mild to moderate pain and to reduce fever. It is also used in combination with opioid analgesics to manage moderate to severe pain in adult and pediatric patients 2 years and older. It works by changing the way the body senses pain and by cooling the body.
How is it administered?
Paracetamol/Acetaminophen will be given by infusion into your veins. Your physician will decide the dose and duration of the infusion based on your disease condition. Do not self-administer the injection. This will take over 15 minutes. Generally, it is given every 4 to 6 hours or as needed to relieve pain or reduce fever.
Side Effects
The common side effects of Paracetamol/Acetaminophen are itchy skin, constipation, nausea, vomiting, headache, insomnia, and agitation. Other serious side effects are liver injury, pneumonitis, and severe skin reactions.
Warnings
Administration of Paracetamol/acetaminophen in doses higher than recommended may result in hepatic injury, including the risk of liver failure and death. Use caution when administering this medicine in patients with the following conditions: hepatic impairment or active hepatic disease, in cases of alcoholism, chronic malnutrition, severe hypovolemia, or severe renal impairment. This medicine may cause severe allergic reactions.
Precautions
Do not take Paracetamol/Acetaminophen if you are allergic to Paracetamol/Acetaminophen or any other ingredients and if you suffer from severe liver disease. Inform your physician if you have liver disease and kidney problems. Notify your physician if you suffer from alcohol abuse. This medicine can be used during pregnancy and breastfeeding. However, inform your physician if you are pregnant or planning to get pregnant during the treatment.
Word of Advice
Do not store above 30°C. Do not refrigerate or freeze. Protect the medicine from light and excessive moisture. Keep the medicine out of reach of children and pets. If you miss a dose, inform your doctor immediately to reschedule. This medicine is administered intravenously through a needle placed in a vein. The medicine will be injected slowly over 15 minutes. A nurse or healthcare provider will administer this medicine. Do not consume alcohol while receiving this injection. This medicine is considered safe when used during pregnancy or breastfeeding. Your doctor will conduct regular laboratory tests at follow-up visits to monitor the effects of this medicine. Attend all scheduled appointments.
References
Perfalgan 10mg/ml Solution for Infusion - Summary of Product Characteristics (SmPC) - (emc). www.medicines.org.uk. Published May 2021. Accessed May 16, 2023. https://www.medicines.org.uk/emc/product/60/smpc Acetaminophen Injection - Highlights of Prescribing Information.; 2021. Accessed May 16, 2023. https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/204957s000lbl.pdf KD Tripathi, Essentials of Medical Pharmacology, Nonsteroidal Anti-inflammatory Drugs and Antipyretics-Analgesics, 7th edition, 2013, 206-207. Goodman & Gilmanâs, The Pharmacological Basics of Therapeutics, Anti-inflammatory, Antipyretic, and Analgesic Agents; Pharmacotherapy of Gout, 12th edition, 2011, 982-984.
Frequently Asked Questions
Why would I need a paracetamol/acetaminophen injection instead of the oral form?
Paracetamol/acetaminophen injection is typically used when immediate and precise pain relief is required or when oral administration is not possible, such as in case of nausea or vomiting. The injection allows for direct delivery of the medication into the bloodstream, resulting in a faster onset of action.
How long does a paracetamol/acetaminophen injection take to start working?
The onset of action for a paracetamol/acetaminophen injection is generally faster than the oral form. Depending on the individual and the specific condition being treated, you may start experiencing pain relief within 5 to 10 minutes after the injection.
Can I self-administer a paracetamol/acetaminophen injection at home?
Healthcare professionals typically administer paracetamol/acetaminophen injections in a clinical setting. Self-administration at home is generally not recommended unless specifically instructed and supervised by a healthcare provider.
Can a paracetamol/acetaminophen injection be used during pregnancy or breastfeeding?
Paracetamol/acetaminophen injections are generally considered safe during pregnancy and breastfeeding when used as directed. However, it is recommended to consult with a healthcare provider before using any medication during these periods to assess appropriate dosage and potential risks.
Can a paracetamol/acetaminophen injection be used for migraine headaches?
Paracetamol/acetaminophen injections can be used for migraine headaches, especially when oral medications are ineffective or tolerated due to severe nausea or vomiting. However, consulting with a healthcare provider for proper diagnosis and treatment options specific to your migraines is recommended.