TELMISARTAN,METOPROLOL,CHLORTHALIDONE

Background and Date of Approval

Telmisartan, metoprolol, and chlorthalidone are antihypertensive agents that work to control high blood pressure and reduce excess water and electrolytes from the body. This combination helps by relaxing blood vessels, making it easier for the heart to pump blood throughout the body, and reduces the risk of heart attack and stroke. Telmisartan received FDA approval for the treatment of hypertension on July 21, 1998. Chlorthalidone received FDA approval for the treatment of hypertension on October 16, 1960. Metoprolol received FDA approval on August 18, 1992.

Uses

Telmisartan+metoprolol+ chlorthalidone is used to treat hypertension.

How is it administered?

This medication is taken as per the advice of the doctor. It can be taken on an empty stomach or along with food, but it has to be taken at a fixed time daily. It’s very important to take this medicine even if you feel well. As it causes frequent urination, it's better to have this tablet 4 hrs before going to bed. The dosage of this medication will depend upon the condition and how individuals respond to the medication. Avoid breaking or chewing the tablet. Instead, swallow it whole with a glass of water.

Side Effects

The common side effects of telmisartan, metoprolol, and chlorthalidone may include dizziness, fatigue, headache, low blood pressure, increased urination, electrolyte imbalances (such as low potassium or sodium levels), and gastrointestinal disturbances like nausea or diarrhea.

Warnings

These medications carry certain warnings and precautions. They should be used cautiously or avoided in individuals with allergies to any components, severe liver or kidney disease, certain heart conditions, or asthma. Chlorthalidone may increase blood sugar levels and requires caution in individuals with diabetes.

Precautions

These medications can also interact with other drugs, so you must inform your healthcare provider about all the medications you are taking. Regular monitoring of blood pressure, electrolyte levels, and kidney and liver function may be necessary during treatment. It is recommended to consult with a healthcare professional for personalized guidance and to ensure safe and appropriate use of these medications.

Word of Advice

Inform your doctor of any history of allergic reactions to prevent serious complications. Advise your doctor before starting treatment if you are pregnant or have liver, kidney, or uterine problems, or if you are taking other medicines for hypertension and heart conditions. During use of this medication, blood pressure, liver function, and blood glucose should be monitored regularly, and kidney function tests should be performed to identify any abnormal changes.

References

KD. Tripathi. Antianginal and Other Anti-ischaemic Drugs & Drugs Affecting Renin-Angiotensin System. Eighth edition. June 2018. Page – 596 & 536. https://www.medicines.org.uk/emc/files/pil.9981.pdf [Revised on November 2019] [Accessed on 26/06/2023] https://go.drugbank.com/drugs/DB00310 [Revised on 8/11/2022) [Accessed on 26/06/2023]

Frequently Asked Questions

Is it safe to use Telmisartan+metoprolol+ chlorthalidone in kidney patients?

This medication is used cautiously in patients with kidney disorders, and dose alteration is required in patients with severe kidney disease. Consult the doctor before taking this medication.

What happens if a patient forgets to take a Telmisartan+metoprolol+ chlorthalidone?

Telmisartan+metoprolol+ chlorthalidone should be taken at the same time every day because missing doses can increase blood pressure and make the condition worse. So it is important to take this medication daily even when the patient is feeling well.

Does Telmisartan+metoprolol+ chlorthalidone cause frequent urination?

Yes. chlorthalidone, which is a water pill or diuretic. It removes excess water and electrolytes from the body and thereby reduces high blood pressure by relaxing the blood vessels.

Can Telmisartan+metoprolol+ chlorthalidone be taken during pregnancy?

It is unsafe to use these medications during pregnancy or in a patient planning for pregnancy because they can cause severe birth defects in the developing child. Inform the doctor before taking this medication.

Can Telmisartan+metoprolol+ chlorthalidone cause dizziness as a side effect?

Yes. This medicine causes dizziness, and tiredness, and patients may feel sleepy, so don't drive or handle heavy machinery because you may lack concentration and alertness.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS