TERIPARATIDE
Background and Date of Approval
Teriparatide is a synthetic agent that received regulatory approval for medical use on 26 November 2002.
Uses
Teriparatide Injection has been developed to treat men and postmenopausal women with osteoporosis or at high risk for fracture who have not responded to other therapies.
How is it administered?
Teriparatide Injection is available as a solution for Injection, cartridge, and pen in doses 600mcg, and 750mcg. It is indicated for administration through a subcutaneous route, into the thigh or abdominal wall. You can take this injection once daily with or without food.
Side Effects
The common side effects that are likely to occur while you are on the treatment with Teriparatide Injection are joint pain, nausea, headache, neck pain, hypertension, constipation, diarrhea, dyspepsia, vomiting, dizziness, depression, insomnia, vertigo, cough, rash, and sweating. If you experience any reactions like rashes, bruising, swelling, and itching at the Injection site, report them to your doctor immediately.
Warnings
Teriparatide Injection is not recommended for patients with an increased risk of bone cancer, which includes people with hereditary bone disorders, skeletal malignancies, and Pagetâs disease. It is also not recommended for patients with urolithiasis, orthostatic hypotension, and hypercalcemia. During the Teriparatide Injection treatment, your doctor may periodically monitor your blood and urine calcium, and kidney parameters to prevent serious complications. Report to your doctor if you have had a history of heart failure or bone disorders. Get immediate medical attention if you have breathlessness or allergies.
Precautions
Teriparatide Injection is not recommended for use during pregnancy and breastfeeding. Tell your healthcare provider before starting this treatment if you are pregnant, think you might be pregnant, breastfeeding, or planning to have a baby.
Word of Advice
Teriparatide injection may cause dizziness, headache and nausea. It is advisable to avoid driving or operating machines during treatment. A cold compress applied to the injection site may help reduce pain.
References
1. KD Tripathi, Hormones and Drugs Affecting Calcium Balance, Essentials of Medical Pharmacology, 8th Edition, 2019, 360-372. 2. Lilly USA, LLC, [Revised on Apr 2021] [Accessed on 23rd Aug 2022], https://pi.lilly.com/us/forteo-pi.pdf 3. Vall H, Parmar M., Teriparatide, [Updated 2022 Jul 12], In: StatPearls [Internet], [Accessed on 23rd Aug 2022], https://www.ncbi.nlm.nih.gov/books/NBK559248/
Frequently Asked Questions
Who should not use Teriparatide Injection?
Teriparatide Injection is not recommended for patients who are hypersensitive to Teriparatide or its excipients.
How do you know if you are allergic to Teriparatide Injection?
Breathlessness and skin reactions like rashes, bruising, swelling and severe itching indicate that you are allergic to Teriparatide Injection. report to your physician right away if you experience any of the above symptoms after taking this Injection.
Is it safe for women of reproductive potential to use Teriparatide Injection?
Teriparatide Injection is not recommended for use during pregnancy and breastfeeding. Tell your healthcare provider before starting this treatment if you are pregnant, think you might be pregnant, breastfeeding, or planning to have a baby.
How is Teriparatide Injection administered?
Teriparatide Injection is given subcutaneously into the thigh or stomach wall. You can take this Injection once a day, with or without food.
How long can you take Teriparatide Injection?
Take Teriparatide Injection for as long as your physician prescribes, but make sure that you don't take this Injection continuously for more than 2 years.
What are the symptoms of Teriparatide overdose?
Signs and symptoms that indicate Teriparatide overdose are nausea, weakness, lethargy, vomiting, dizziness and headache.
What should you do if you overdose on Teriparatide?
Report to your physician immediately if you overdose on Teriparatide. your physician will suggest discontinuation of Teriparatide treatment, monitoring blood calcium and phosphorus, and might recommend a high intake of water.
What should you not take with Teriparatide Injection?
Do not take Teriparatide Injection if you are taking medications for heart problems like digitalis or digoxin. Also, tell your physician if you are taking any other prescription medication, over-the-counter drugs, vitamins or herbal supplements.