TICAGRELOR,ASPIRIN
Background and Date of Approval
Ticagrelor and Aspirin combination is an antiplatelet medication. Ticagrelor received US FDA approval on July 20, 2011, and Aspirin received US FDA approval on June 1, 1960. It is indicated to reduce the risk of myocardial infarction, stroke, and cardiovascular events in patients with acute coronary syndrome (ACS) or in those with a history of myocardial infarction.
Uses
Ticagrelor and Aspirin are used together to reduce the risk of heart attacks, strokes, and other serious cardiovascular events. They work by preventing blood clots from forming in the arteries. This combination is commonly prescribed for patients with acute coronary syndrome or those who have recently had a heart attack.
How is it administered?
Ticagrelor and Aspirin are usually taken orally as tablets. Do not break, chew, or crush the tablets. It is recommended to take them after food to minimise the risk of stomach upset. Consult your healthcare provider for the correct dosage. If you miss a dose, do not double the next dose; instead, consult your healthcare provider for advice.
Side Effects
Side effects are unwanted symptoms caused by medicines. Although all drugs can cause side effects, not everyone experiences them. Common side effects of Ticagrelor and Aspirin: Headache Dizziness Nausea Bruising Stomach pain or discomfort Serious side effects of Ticagrelor and Aspirin: Severe bleeding (e.g., in the stomach or brain) Shortness of breath or difficulty breathing Chest pain or rapid heart rate Unusual tiredness or weakness Black or bloody stools Vomiting blood
Warnings
Bleeding Risk: Both Ticagrelor and Aspirin increase the risk of bleeding, including serious internal bleeding. Avoid using them if you have a history of bleeding disorders. Heart Issues: Ticagrelor may cause shortness of breath or slow heart rate. Inform your healthcare provider if you have a history of heart problems. Liver and Kidney Conditions: Use caution if you have liver or kidney problems, as the drugs may affect these organs. Stop Before Surgery: Discontinue Ticagrelor and Aspirin at least 5 days before any surgery or dental procedures to reduce bleeding risk. Allergic Reactions: Severe allergic reactions, including swelling and difficulty breathing, may occur. Seek immediate medical help if this happens. Avoid Alcohol: Limit alcohol consumption while taking these medications, as it can increase the risk of stomach bleeding. Pregnancy and Breastfeeding: Consult your doctor before using these medications if you are pregnant or breastfeeding.
Precautions
Take Ticagrelor and Aspirin with caution if you have a history of bleeding disorders, stomach ulcers, or heart problems. Inform your doctor if you are pregnant, breastfeeding, or planning surgery. Regular monitoring may be required to check for any potential side effects. Always follow your healthcare provider's advice regarding dosage and usage.
Word of Advice
Take Ticagrelor and Aspirin exactly as prescribed by your doctor. Do not omit doses or discontinue treatment without consulting your healthcare provider, as interruption may increase the risk of serious cardiac or vascular events. Inform your doctor of all other medications you are currently taking. If you experience unusual bleeding or any adverse effects, seek immediate medical attention.
References
1. Tomaniak M, Chichareon P, Onuma Y, Deliargyris EN, Takahashi K, Kogame N, Modolo R, Chang CC, Rademaker-Havinga T, Storey RF, Dangas GD, Bhatt DL, Angiolillo DJ, Hamm C, Valgimigli M, Windecker S, Steg PG, Vranckx P, Serruys PW; GLOBAL LEADERS Trial Investigators. Benefit and Risks of Aspirin in Addition to Ticagrelor in Acute Coronary Syndromes: A Post Hoc Analysis of the Randomized GLOBAL LEADERS Trial. https://pmc.ncbi.nlm.nih.gov/articles/PMC6764000/ 2. Li J, Sheng Z, Tan Y, Liu C, Zhou P, Zhou J, Chen R, Chen Y, Song L, Zhao H, Yan H. Combined with ticagrelor, 50 mg aspirin daily can reduce bleeding events without increasing ischemic risk compared with 75-100 mg aspirin daily in coronary artery disease patients: insights from the TIFU (Ticagrelor in Fuwai Hospital) study. https://pubmed.ncbi.nlm.nih.gov/31645164/ 3. Traby L, Kollars M, Kaider A, Siller-Matula JM, Wolkersdorfer MF, Wolzt M, Kyrle PA, Eichinger S. Differential Effects of Ticagrelor With or Without Aspirin on Platelet Reactivity and Coagulation Activation: A Randomized Trial in Healthy Volunteers. https://pmc.ncbi.nlm.nih.gov/articles/PMC7006887/
Frequently Asked Questions
What are the main side effects of the Ticagrelor and Aspirin combination?
The main side effects of the Ticagrelor and Aspirin combination include an increased risk of bleeding, bruising, stomach pain, and indigestion. Some people may also experience shortness of breath, dizziness, or headache. If you notice any severe side effects, such as unusual bleeding or difficulty breathing, seek medical attention immediately.
Does Ticagrelor and Aspirin combination reduce platelets?
Yes, the Ticagrelor and Aspirin combination reduces platelet activity. Ticagrelor inhibits platelet activation by blocking the P2Y12 receptor, while Aspirin prevents the production of thromboxane A2, both of which reduce platelet aggregation and help prevent blood clot formation.
Is Ticagrelor and Aspirin combination a high-risk medication?
Yes, the Ticagrelor and Aspirin combination carries a higher risk of bleeding, which can be serious. It is essential to use this medication under strict medical supervision.
What to avoid when taking Ticagrelor and Aspirin combination?
When taking Ticagrelor and Aspirin, avoid alcohol as it increases the risk of bleeding and stomach issues. Also, avoid taking other blood-thinning medications without consulting your doctor to prevent excessive bleeding.
Can Ticagrelor and Aspirin combination affect kidneys?
Yes, the combination of Ticagrelor and Aspirin can affect kidney function, particularly in people with pre-existing kidney conditions. It is important to monitor kidney function regularly while using this combination. Always inform your doctor if you have kidney issues before starting treatment.