VECURONIUM BROMIDE

Vecuronium bromide received FDA approval on 2/10/1999 for use as a skeletal muscle relaxant during surgical procedures.

Vecuronium bromide is administered as an adjuvant to general anesthesia to prepare you for surgery. This medication assists in maintaining your body still by relaxing your skeletal muscles during the surgical procedure. It also facilitates the relaxation of the throat, making inserting a breathing tube (endotracheal intubation) easier before surgery. This medication is used as a muscle relaxant in almost all age groups, including adults, adolescents (2-17 years), newborns, and infants (0 days – 23 months). It is also employed to aid in emergency airway management (mechanical ventilation) for patients in intensive care.

Vecuronium bromide injection is available in 3 different strengths: 4mg, 10mg, and 20mg. It is given intravenously (into a vein), either as single injections or as a continuous infusion (a drip) by your healthcare provider. Your physician will decide the dosage of this injection based on the severity of your disease and other factors.

Vecuronium bromide can cause some side effects like any other drug. If any side effects occur while you are under anaesthetic, they will be seen and treated by your doctor. Some of the serious side effects are prolonged paralysis (seen in long-term use), bronchospasm/respiratory depression (difficulty breathing), apnea (when you stop breathing), and anaphylaxis (sudden allergic reactions). Seek medical attention immediately if any of these side effects occur. Some of the common side effects are injection site pain and muscle weakness.

Before receiving vecuronium bromide, it is crucial to discuss the following with your healthcare team: any prior allergies to vecuronium bromide or other muscle relaxants, reduced renal function or renal disease, heart or circulatory conditions, fluid accumulation, liver or gallbladder issues, edema (swelling of ankles), diseases affecting nerves and muscles such as polio, myasthenia gravis or Eaton-Lambert syndrome. Transparent communication about your medical history is essential for a safe and effective treatment plan.

Inform your doctor if you are pregnant or breastfeeding before the treatment. Do not drive or use heavy machinery until you are told okay since vecuronium bromide might make you weak or dizzy. Your anesthesia doctor will tell you when it is safe to resume these activities and how long these feelings might last.

This medicine is intended only for use in a hospital and will be given by your doctor during surgery. While vecuronium bromide is being administered, your doctor will closely monitor you to evaluate its effects. Since this injection causes muscle relaxation, including relaxation of the muscles needed for breathing, you will need assisted breathing or artificial ventilation during and after the procedure until you are able to breathe on your own. If you have any questions or concerns, discuss them with your doctor before receiving the medication. Your safety and comfort will be carefully monitored throughout the treatment.

Sun Pharma, Electronic medicines compendium (EMC), [Revised on Jun 2019], [Accessed on 25th Sept 2023], https://www.medicines.org.uk/emc/product/2619/smpc Ben Venue Laboratories, US Food and Drug Administration (FDA), [Revised on Jul 2018], [Accessed on 25th Sep 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/075549s013lbl.pdf Mark Ramzy et al.; Vecuronium, Published on Dec 2022; Accessed on 25/09/2023; https://www.ncbi.nlm.nih.gov/books/NBK493143/ KD Tripathi, Essentials of Medical Pharmacology, Skeletal muscle relaxants, 8th edition, 2019, 379 Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Agents acting at the neuromuscular junction and autonomic ganglia, 13th edition, 2018, 188