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Acabrunat 100mg Capsule

Salt Composition: ACALABRUTINIB

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Acabrunat 100mg Capsule

Categories: Oncology

Conditions: Anti Cancer

Product Introduction

Acabrunat 100mg Capsule is an anticancer medicine containing the active constituent acalabrutinib. It belongs to a class of drugs called Bruton's tyrosine kinase (BTK) inhibitors. It is used to treat mantle cell lymphoma (MCL), chronic lymphocytic leukaemia (CLL), and small lymphocytic lymphoma (SLL). MCL, CLL, and SLL are cancers of the wbcs called lymphocytes that are part of the immune system. They differ from each other by the location where cancer occurs and the type of lymphocytes affected. Before taking this medicine, inform your doctor if you have had recent surgery, bleeding problems, heart rhythm problems, infection, are pregnant, or are breastfeeding. It is not recommended for children and adolescents less than 18 years. This medicine can increase the risk of bleeding. Patients with Acabrunat 100mg Capsule should be monitored for signs of bleeding and should avoid taking other medications that can increase the risk of bleeding, such as blood thinners.

Uses

The Acabrunat 100mg Capsule is used in the treatment of Chronic lymphocytic leukemia Small lymphocytic lymphoma Mantle cell lymphoma

How it works

The therapeutic effect of Acabrunat 100mg Capsule is to inhibit the activity of Bruton's tyrosine kinase (BTK), a protein that is essential for the survival and growth of cancer cells in certain types of lymphomas and leukemias. By blocking BTK, it can help to slow down or even stop the growth and spread of cancer cells, which can lead to a reduction in tumor size, an improvement in symptoms, and a delay in disease progression.

How to Use

Acabrunat 100mg Capsule is typically taken orally, with or without food. The tablets should be swallowed whole, not crushed, chewed, or broken. The recommended dosage can vary depending on the type of cancer being treated and other factors such as your overall health and response to treatment. Do not take a double dose to make up for a missed dose.

Side Effects

Like all medications, Acabrunat 100mg Capsules cause some side effects, although not everyone will experience them. Serious: Bleeding problems (bruising or bleeding) Infections (pneumonia and sepsis) High blood pressure Heart problems (irregular heartbeat and chest pain) Kidney failure Common: Headache Diarrhea Nausea Fatigue Muscle and joint pain Bruising or bleeding easily Upper respiratory tract infection Rash or itching

Expert Tips

If you have been prescribed Acabrunat 100mg Capsule, it is important to carefully read and understand the warnings and precautions associated with the medication. Patients require monitoring for signs of an allergic reaction. It can cause high blood pressure. Patients should check their blood pressure regularly. Report to your doctor if you develop a lesion or change in the appearance of an area on the skin. It increases the risk of infection, so patients should avoid close contact with infected persons. Patients with diabetes require close monitoring during treatment. Pregnancy and breastfeeding should be avoided during treatment. Always maintain a healthy and balanced diet to support your overall health and well-being.

References

  1. AstraZeneca, Electronica medicines compendium (EMC), [Revised on Dec 2020], [ Accessed on 5th May 2023], https://www.medicines.org.uk/emc/files/pil.11917.pdf
  2. AstraZeneca, US Food and Drug Administration, [ Revised on Oct 2017], [ Accessed on 5th May 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/210259s000lbl.pdf
  3. John C Byrd et al; Acalabrutinib monotherapy in patients with relapsed/refractory chronic lymphocytic leukemia: updated phase 2 results; Blood; Published on April 2020; [Accessed on 5th May 2023]; https://pubmed.ncbi.nlm.nih.gov/31876911/

Safety Advice

Pregnancy: unsafe Acabrunat 100mg Capsule is unsafe during pregnancy. It can harm the developing fetus, so pregnancy should be avoided while taking this medicine.

Lungs: Consult your doctor If you have a lung disease or lung cancer and are considering treatment with Acabrunat 100mg Capsule, it is important to discuss this medication's potential benefits and risks with your healthcare provider.

Breastfeeding: Consult your doctor It is unknown whether Acabrunat 100mg Capsule is excreted into human breast milk, so breastfeeding women should consult a doctor before taking it.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS