Actemra 400mg Injection

Actemra 400mg injection contains tocilizumab, a monoclonal antibody derived from specific immune cells. It is indicated for moderate to severe active rheumatoid arthritis (RA) in patients with inadequate response to other rheumatoid drugs, giant cell arteritis, systemic juvenile idiopathic arthritis (sJIA) in children, and polyarticular juvenile idiopathic arthritis (pJIA) in children aged 1 year and above, where it reduces pain and swelling in one or more joints.

Children with allergies to any component and those with severe infections require medical assessment prior to treatment. Patients should inform their doctor of any allergic reaction including difficulty breathing, chest tightness, rash, itching, hives, or swelling of lips, tongue, or face. Medical attention is necessary for active infection (short-term or long-term), tuberculosis, intestinal ulcers, diverticulitis (small bulging pouches in the digestive tract), liver disease, cancer, kidney function impairment, and persistent headaches. A history of macrophage activation syndrome (activation and uncontrolled proliferation of specific blood cells) should be disclosed to the doctor. Elderly patients carry increased risk of infection compared to the general population and require careful monitoring during treatment. Medical consultation is advised if pregnancy is planned, suspected, or during breastfeeding.

Rheumatoid arthritis Giant cell arteritis (GCA) Polyarticular Juvenile Idiopathic Arthritis (pJIA) Systemic Juvenile Idiopathic Arthritis (sJIA) Cytokine release syndrome

Actemra 400mg injection inhibits the function of a particular protein known as interleukin-6, which plays a role in the body's inflammatory responses. By blocking this protein, it can help decrease inflammation within your body.

Actemra 400mg injection will be administered to you by a healthcare professional in a hospital setting. It is usually administered in the vein (intravenous). Your doctor will decide the dose, route of administration, and frequency based on your disease condition and other factors.

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them. Serious Allergic reaction (difficulty with breathing, chest tightness, rash, itching, hives, swelling in the lips, tongue, or face) Fever and chills Mouth or skin blisters Stomach ache Common Upper respiratory tract infections (cough, blocked nose, runny nose, sore throat and headache) High blood fat (cholesterol) levels Injection site reactions. Lung infection (pneumonia) Shingles (herpes zoster) Cold sores (oral herpes simplex), blisters Eye infection (conjunctivitis) Headache, dizziness, high blood pressure Mouth ulceration, stomach pain Fluid retention (edema) in the lower legs, weight increase Cough, shortness of breath Low white blood cell counts (neutropenia, leucopenia) Abnormal liver function tests (increased transaminases) Increased bilirubin shown by blood tests Low fibrinogen levels in the blood (a protein involved in blood clotting)

Talk to your doctor if you have recently been vaccinated or are planning a vaccination because a certain vaccination (Live vaccine) should not be given while taking actemra 400mg injection. Your doctor will advise you to check the blood if you have low white blood cells, platelets, or elevated liver enzymes before giving you the medicine.