Actilyse 20mg Injection

Actilyse 20mg injection contains alteplase, a recombinant tissue plasminogen activator (rt-PA), used to treat medical conditions involving blood clots. It is a thrombolytic agent that works to break down blood clots. This medication is commonly used to manage acute ischemic stroke, where a blood clot obstructs blood flow to the brain and risks brain damage. When administered within a specific time window after stroke symptom onset, alteplase aims to restore blood flow to affected brain tissue and reduce the risk of long-term disability. By restoring blood flow to the affected brain area, Actilyse 20mg injection can help minimise the extent of brain tissue damage caused by stroke. This may result in reduced long-term disability and an improved recovery outlook for patients with stroke.

Like all medications, this injection carries potential side effects and may not be suitable for every patient. Common side effects include bleeding, particularly intracranial or gastrointestinal bleeding. Prior to administration, doctors typically assess the patient's medical history and evaluate contraindications.

Patients with known allergy or hypersensitivity to alteplase or any component of Actilyse 20mg injection should not receive this medication. Patients with significant trauma (head trauma or internal injuries) within the past three months face increased bleeding risk and should avoid this medication. Actilyse is cleared from the body through the liver and kidneys; caution is advised in patients with severe liver or kidney impairment. Advanced age increases the risk of bleeding complications with this medication, particularly in patients over 75 years.

Actilyse 20mg injection is used to treat the following: Heart attack Acute ischemic stroke Acute massive pulmonary embolism (blood clots in the lung)

Actilyse 20mg injection converts plasminogen enzyme to plasmin, which helps in breaking down of fibrin present in blood clots, which leads to restoration of blood flow. So it is used in acute ischemic stroke; it dissolves clots, minimizing damage.

Actilyse 20mg injection is administered intravenously (injection in a vein) under medical supervision. Your healthcare professional will determine the specific dosage and administration guidelines based on your condition and needs.

Actilyse 20mg injection cause some side effects like all medications, although not everyone will experience them. Serious: Bleeding Allergic reactions Hypotension (low blood pressure) Cardiac arrhythmias Hypersensitivity reactions Common: Low blood pressure Chest pain Fluid on the lungs Bleeding of the damaged blood vessel Bleeding at the injection site

Advice regarding Actilyse 20mg injection is to always consult with a healthcare professional before starting or making any changes to your medication regimen. Tell your doctor if you have a history of bleeding disorders, recent surgery or trauma, gastrointestinal bleeding, or other conditions that may increase bleeding risk. Close monitoring of patients is required throughout treatment to detect any bleeding or adverse reactions promptly. It should be used in a hospital setting with access to emergency facilities, and immediate medical care must be available in case of complications. Pregnancy and breastfeeding women should consult a doctor before starting treatment. Advanced age can increase the risk of bleeding complications with this medication, particularly in patients over 75. The dosage adjustment is required in elderly patients.