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Actilyse 50mg Injection

Salt Composition: ALTEPLASE

₹39938.00₹49921.88

Inclusive of all taxes

Actilyse 50mg Injection

Categories: Cardiology

Conditions: Heart Disorder

Product Introduction

Actilyse 50 mg injection contains alteplase, also known as recombinant tissue plasminogen activator (rt-PA). It is a thrombolytic agent used to treat medical conditions involving blood clots by helping to break down clots. Actilyse is commonly used to manage acute ischaemic stroke, where a blood clot blocks blood flow to the brain and may cause brain damage. When administered within a specific time frame after stroke symptom onset, Actilyse aims to restore blood flow to affected brain tissue and reduce the risk of long-term disability. By restoring blood flow to the affected brain area, Actilyse 50 mg injection can help minimise the extent of brain tissue damage caused by stroke, potentially reducing long-term disability and improving recovery prospects for patients with stroke.

As with any medication, Actilyse 50 mg can cause side effects and may not be suitable for every patient. Common side effects include bleeding, particularly in the brain or gastrointestinal tract. Before administration, doctors typically assess the patient's medical history and consider any contraindications.

Patients with known allergy or hypersensitivity to Actilyse 50 mg injection or any of its components should not receive this medication. Patients with significant trauma (head trauma or internal injuries) within the past three months should avoid this medication due to increased risk of bleeding. A common Actilyse 50 mg substitute is Streptokinase Injection, though the choice of alternative depends on the patient's condition and should always be decided by a doctor.

This medication is cleared from the body through the liver and kidneys; caution is advised in patients with severe liver or kidney impairment. Advanced age can increase the risk of bleeding complications with this medication, particularly in patients over 75 years. Actilyse 50 mg price depends on the retailer and may vary from place to place.

Uses

The Actilyse 50 mg uses include: Heart attack Acute ischemic stroke Acute massive pulmonary embolism (blood clots in the lung)

How it works

Actilyse 50mg injection converts plasminogen enzyme to plasmin, which helps in breaking down of fibrin present in blood clots, which leads to restoration of blood flow. So it is used in acute ischemic stroke; it dissolves clots, minimizing damage.

Side Effects

Actilyse 50 mg injection side effects like all medications, although not everyone will experience them. Serious side effects of Actilyse 50mg Injection are: Bleeding Allergic reactions Hypotension (low blood pressure) Cardiac arrhythmias Hypersensitivity reactions Common side effects of Actilyse 50mg Injection are: Low blood pressure Chest pain Fluid on the lungs Bleeding of the damaged blood vessel Bleeding at the injection site

References

  1. KD Tripathi, Essentials of Medical Pharmacology, Drugs affecting coagulation, bleeding and thrombosis, 7th edition, 2013, 627.
  2. Boehringer Ingelheim International GmbH, European medicines compendium (emc), [Revised on April 2021] [ Accessed on 24th March 2023], https://www.medicines.org.uk/emc/files/pil.10361.pdf
  3. Genentech, Inc, US Food and Drug Administration, [Revised on August 2001] [Accessed on 24th Jult 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2001/altegen090401lb.pdf

Safety Advice

Pregnancy: Consult your doctor If a pregnant woman requires treatment with Actilyse 50mg injection, then they should consult a healthcare provider. They will weigh the potential benefits of resolving the critical situation against the potential risks to the developing fetus.

Lungs: unsafe Using Actilyse 50mg injection for lung-related conditions requires expert medical care and a multidisciplinary approach. It should only be administered in a hospital setting by healthcare professionals experienced in managing such cases.

Breastfeeding: Consult your doctor If you are breastfeeding, it is essential to consult with a healthcare professional for personalized advice and guidance before starting treatment with ateplase.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS