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Adhestop 25000IU Injection

Salt Composition: HEPARIN

₹286.00₹317.81

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Adhestop 25000IU Injection

Categories: Cardiology

Conditions: Anticoagulants

Product Introduction

Adhestop 25000IU Injection contains Heparin as its active component. It is an anticoagulant medication that prevents the formation of blood clots and is commonly prescribed across various clinical settings to reduce clotting risk, particularly in patients at elevated risk of thrombosis. Adhestop 25000IU Injection is frequently used in hospital settings for the prevention and treatment of deep vein thrombosis (DVT), pulmonary embolism (PE), and other conditions where blood clot formation presents a clinical concern. It is also administered during certain surgical procedures and in dialysis to prevent clotting within the extracorporeal circuit. Since therapeutic response varies among individuals, administration requires careful monitoring of blood clotting parameters, typically through the activated partial thromboplastin time (aPTT) test. Dosage may require adjustment to maintain therapeutic levels. In cases of excessive bleeding or overdose with Adhestop 25000IU Injection, protamine sulfate serves as an antidote to reverse its effects. Patients with known hypersensitivity or allergic reactions to this medication should not use Adhestop 25000IU Injection. Although generally well tolerated, it may be unsuitable for patients with certain medical conditions, including bleeding disorders or recent major surgery. Inform your healthcare provider of any existing medical conditions and all medications currently being taken before initiating therapy. Elderly patients may have increased susceptibility to bleeding complications, and lower dosages or intensified monitoring may be warranted. Impaired liver or kidney function can affect the medication's metabolism and elimination, potentially increasing the risk of adverse effects. Dosing adjustments may be necessary for patients with these conditions.

Uses

Adhestop 25000IU Injection is used to treat the following: Deep vein thrombosis Pulmonary embolism Disseminated intravascular coagulation Venous thromboembolism prophylaxis Atrial fibrillation with a high risk of stroke Hemodialysis Pregnancy-related thrombosis

How it works

Adhestop 25000IU Injection enhances the activity of antithrombin III, a natural anticoagulant protein in the body. By binding to antithrombin III, this medication accelerates its inhibitory effect on clotting factors, particularly thrombin and factor Xa. This inhibition disrupts the blood coagulation cascade, preventing fibrin formation, an essential component of blood clots. As a result, this medication effectively reduces the risk of clot formation and growth, making it a valuable anticoagulant used in various medical conditions.

How to Use

Adhestop 25000IU Injection is typically administered by injection either intravenously (IV) or subcutaneously (under the skin). The specific dosage and administration method depends on the medical condition being treated, the patient's weight, age, and other factors, which a healthcare professional should determine. For IV use, this medication is usually given in a hospital setting under continuous monitoring to adjust the dosage as needed. Subcutaneous injections are often used for prophylactic purposes or in outpatient settings.

Side Effects

Adhestop 25000IU Injection causes some side effects like all medications, although not everyone will experience them. Serious: Severe allergic reactions, including rash, itching, swelling, severe dizziness, or difficulty breathing Bleeding Adhestop 25000IU Injection-induced thrombocytopenia (HIT) Osteoporosis (bone weakness) Common: Bruising Hematomas Pain at Injection Site Redness at Injection Site Elevated Liver Enzymes Fever Nausea Vomiting

Expert Tips

Patients should inform their healthcare providers about their medical history, including any bleeding disorders, liver or kidney problems, recent surgeries, and allergies, to determine the appropriate dosage and administration method. Regular monitoring of blood clotting parameters, such as activated partial thromboplastin time (aPTT) or anti-Xa assay, is crucial to maintain the desired anticoagulant effect and prevent bleeding or thrombosis. Patients should follow the prescribed dosage and administration instructions precisely and report any unusual bleeding, bruising, or allergic reactions promptly. It is advisable to avoid activities or medications that may increase the risk of bleeding while on Adhestop 25000IU Injection. By adhering to these instructions and maintaining open communication with healthcare providers, patients can minimize risks and maximize the benefits of this therapy.

References

  1. Wockhardt UK Ltd, Electronic medicines compendium (EMC), [Revised on June 2018] [ Accessed on 30th July 2023], https://www.medicines.org.uk/emc/files/pil.1678.pdf
  2. Baxter Healthcare Corporation, US Food, and Drug Administration, [Accessed on 30th July 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/017037s158lbl.pdf
  3. KD Tripathi, Essentials of Medical Pharmacology, Drugs affecting coagulation, bleeding, and thrombosis, 7th edition, 2013, 617

Safety Advice

Pregnancy: safe Adhestop 25000IU Injection is generally considered safe to use during pregnancy, and it is often preferred over certain other anticoagulants, especially vitamin K antagonists like warfarin. This preference is due to its minimal placental transfer, which means it does not cross the placenta to a significant extent and has a lower risk of harming the developing fetus.

Lungs: safe Adhestop 25000IU Injection is generally safe for the lungs, as it is an anticoagulant primarily used to prevent and treat blood clots in the circulatory system, not the lungs directly. It is often used to treat conditions like pulmonary embolism (PE), where blood clots block blood flow to the lungs.

Breastfeeding: Consult your doctor While Adhestop 25000IU Injection is considered safe during breastfeeding, as with any medication, nursing mothers need to discuss their specific situation with a healthcare provider.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS