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Azel 40mg Capsule

Salt Composition: ENZALUTAMIDE

₹5681.00₹8156.25

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Azel 40mg Capsule

Categories: Oncology

Conditions: Anti Cancer

Product Introduction

Azel 40mg capsule contains enzalutamide, an antineoplastic agent belonging to the class of androgen receptor inhibitors. It is indicated for treatment of advanced prostate cancer in patients who have not responded to surgical or hormonal therapy.

Do not take this capsule if you are allergic to any of its ingredients.

During treatment, your doctor may order periodic prostate-specific antigen (PSA) tests. This blood test measures PSA levels, a protein produced by the prostate gland that can be elevated in men with prostate cancer. PSA monitoring helps assess disease progression and treatment response. Your doctor may also arrange liver function tests and complete blood count (CBC) to identify potential serious complications.

This medicine can cause seizures. Patients with a history of seizures should exercise caution when taking this medication.

Avoid grapefruit and grapefruit juice during treatment, as these can increase medicine levels in the body.

This drug is not recommended during pregnancy as it causes harm to the unborn baby and causes fertility issues. Inform your doctor of any fertility concerns before beginning treatment. Tell your healthcare provider if you are pregnant or planning to have a baby before starting this treatment. Both men and women should use effective contraceptive methods during treatment and for 3 months after the last dose of Azel 40mg capsule.

Uses

Advanced prostate cancer

How it works

It works by inhibiting the active form of testosterone, called dihydrotestosterone. It selectively blocks the androgen receptors and disrupts the translocation of signals from the receptor to the cell. Thus, the androgen hormone does not bind to the androgen receptors and these androgen receptors do not interact with DNA. This blocks the functioning of cancer cells and reduces its multiplication.

How to Use

Your doctor will decide the dose and duration of Azel 40mg capsule based on the disease condition and other factors. Always take this medicine as prescribed by your doctor. The standard dose for this drug is 160 mg taken once daily, with or without food. Do not chew, crush, or break the capsule. Swallow the whole capsule with water. If you forgot to take the capsule, simply take your next dose at the scheduled time. Do not take a double dose to make up for a forgotten dose.

Side Effects

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them. Serious Hypersensitivity Seizures Posterior reversible encephalopathy syndrome Heart disease Falls and fractures Common Tiredness Back pain Constipation Arthralgia Decreased appetite Diarrhea High BP Headache Anxiety Dry skin Enlarged breasts in men Inability to concentrate

Expert Tips

Azel 40mg capsule causes skin dryness so it is advised to use an effective moisturiser for your skin. Ensure that you stay hydrated and maintain a balanced diet. Store the drug in the original package at room temperature (25°C). Keep it out of reach from children and pets. It is important to get the dose at the scheduled time. If you missed the schedule, contact your doctor and reschedule the dose. Avoid driving or operating heavy machines if you experience dizziness, nausea or tiredness while on treatment with this drug.

References

  1. Astellas Pharma Ltd, [Revised on Oct 2020] [Accessed on 8th Apr 2021], https://www.astellas.us/docs/12a005-enz-wpi.pdf
  2. Astellas Pharma Europe B.V, Electronic Medicines Compendium (EMC), [Revised on May 2021] [Accessed on 12th Nov 2021], https://www.medicines.org.uk/emc/files/pil.10318.pdf
  3. Martín LázaroQuintela et al., Enzalutamide: a new prostate cancer targeted therapy against the androgen receptor, Cancer Treatment Reviews. Mar 2015; 41(3): 247-253 [Accessed on 8th Apr 2021],
  4. https://ruc.udc.es/dspace/bitstream/handle/2183/21551/Lzro_Enzlutamide.pdf?sequence=3&isAllowed=y
  5. Marina D. Kaymakcalan and Christy S. Harris, Prostate Cancer, Applied Therapeutics, The Clinical Use Of Drugs, 11th Edition, 2018, 2083-2100.

Safety Advice

Pregnancy: unsafe Azel 40mg capsule is not recommended for pregnant women as they may cause fetal harm. Consult your doctor if you are pregnant or planning for pregnancy during the treatment.

Lungs: Consult your doctor It is not known whether Azel 40mg capsule can be prescribed to patients with lung problems. Consult your doctor if you have any lung diseases before starting the treatment.

Breastfeeding: Consult your doctor It is not known if Azel 40mg capsule passes into your breast milk or if it will affect your baby or your breast milk. Talk to your doctor about the best way to feed your baby if you receive this drug.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS