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Bortenat 2mg Injection

Salt Composition: BORTEZOMIB

₹1571.00₹2613.68

Inclusive of all taxes

Categories: Oncology

Conditions: Anti Cancer

Product Introduction

Bortenat 2mg Injection is a chemotherapy medication belonging to the class of proteasome inhibitors. It contains the active ingredient Bortezomib and is indicated for the treatment of multiple myeloma and mantle cell lymphoma. Multiple myeloma is a malignancy of plasma cells predominantly found in bone marrow. Mantle cell lymphoma is a less common cancer affecting the lymph nodes. This medication is used concomitantly with other chemotherapy medicines including pegylated liposomal doxorubicin, rituximab, cyclophosphamide, doxorubicin, dexamethasone, prednisolone or thalidomide in patients who have not started treatment and are ineligible for blood stem cell transplant. Common side effects associated with Bortenat 2mg Injection include pneumonia, loss of appetite, sensitivity, tingling and burning sensation of the skin, nausea, vomiting, diarrhoea, mouth ulcers, constipation, muscle and bone pain, hair loss, fever, infections, itching, redness, dehydration and stomach problems. Inform your physician if these side effects are bothersome or persistent. Inform your doctor if you are allergic to Bortenat Injection or any of its ingredients. Do not use this medication if you have severe lung or heart problems. Before commencing treatment, inform your physician if you are experiencing neuropathy (nerve malfunction), cardiac disorders, severe lung problems, pulmonary disorders, posterior reversible encephalopathy syndrome, gastrointestinal disorders, thrombocytopenia (low platelet count), neutropenia (low white blood cell count), tumour lysis syndrome (metabolic abnormalities occurring as a complication during cancer treatment) or hepatic disorders. Inform your doctor of diabetes, as this injection can affect your blood glucose levels.

Uses

Bortenat uses are: Treatment of multiple myeloma and mantle cell lymphoma.

How it works

Bortenat 2mg Injection Injection works by exerting a toxic effect on cancer cells. It inhibits the 26S proteasome and blocks a major cell signaling pathway. This inhibition of the signaling pathway makes the cancer cells sensitive to chemotherapy. This medicine also enhances the build-up of a protein and minimizes cancer cell growth and multiplication.

Side Effects

Bortenat side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Serious Muscle cramps Confusion, visual disturbances, seizures, and headache Breathlessness Swelling of feet Changes in heartbeat High blood pressure Fainting and tiredness Cough and chest tightness Common Pneumonia Loss of appetite Sensitivity, tingling and burning sensation of the skin Nausea, vomiting, and diarrhea Mouth ulcers Constipation Muscle and bone pain Hair loss Fever Reduction in blood cell count Reduced kidney function Shivering Infections Itching and redness Dehydration Stomach problems Difficulty sleeping, anxiety, mood swings, depressed mood

References

  1. STADA, Electronic Medicines Compendium (EMC), [Revised on Nov 2021] [Accessed on 30 Nov 2022], https://www.medicines.org.uk/emc/files/pil.10201.pdf
  2. Takeda Pharmaceuticals U.S.A., Inc., [Revised on Aug 2022] [Accessed on 30 Nov 2022], https://www.velcade.com/files/pdfs/VELCADE_PRESCRIBING_INFORMATION.pdf
  3. Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.
  4. KD Tripathi, Anticancer Drugs, Essentials of Medical Pharmacology, 8th Edition, 2019, 915-936.
  5. H.G. Watson, J.I.O. Craig, L.M. Manson, Blood disease, Davidson’s Principles and Practice of Medicine, 22nd Edition, 2014, 989-1056

Safety Advice

Pregnancy: unsafe Bortenat 2mg Injection is unsafe to use during pregnancy unless clearly necessary. Both women of childbearing potential and men must use an effective contraception method during and three months after treatment.

Lungs: Consult your doctor It is unknown whether Bortenat 2mg Injection can be given to lung failure patients. Please consult your physician if you have any lung diseases.

Breastfeeding: unsafe Bortenat 2mg Injection is unsafe to use during breastfeeding. Please discuss with your physician when it is safe to restart breastfeeding after this treatment.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS