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Bortero 2mg Injection

Salt Composition: BORTEZOMIB

₹1166.00₹1976.02

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Bortero 2mg Injection

Categories: Oncology

Conditions: Anti Cancer

Product Introduction

Bortero 2mg Injection is a chemotherapy medication belonging to the proteasome inhibitor class. Its active ingredient is Bortezomib. It is indicated for the treatment of multiple myeloma and mantle cell lymphoma. Multiple myeloma is a malignancy of plasma cells that arise in the bone marrow. Mantle cell lymphoma is a less common cancer affecting the lymph nodes. This medication is used concurrently with other chemotherapy agents including pegylated liposomal doxorubicin, rituximab, cyclophosphamide, doxorubicin, dexamethasone, prednisolone or thalidomide in patients with newly diagnosed disease who are ineligible for blood stem cell transplant. Common side effects associated with Bortero 2mg Injection include pneumonia, loss of appetite, sensitivity, tingling and burning sensation of the skin, nausea, vomiting, diarrhoea, mouth ulcers, constipation, muscle and bone pain, hair loss, fever, infections, itching, redness, dehydration and gastrointestinal disturbances. Inform your physician if these side effects become troublesome or persist. Inform your doctor if you are allergic to Bortero 2mg Injection and its ingredients. Do not use this medication if you have severe lung or cardiac problems. Before starting treatment, inform your physician if you have neuropathy (nerve malfunction), cardiac disorders, severe lung problems, pulmonary disorders, posterior reversible encephalopathy syndrome, gastrointestinal disorders, thrombocytopenia (low platelet count), neutropenia (low white blood cell count), tumour lysis syndrome (metabolic abnormalities that can occur during cancer treatment) or hepatic disorders. Inform your doctor if you have diabetes, as this injection can affect your blood glucose levels.

Uses

Treatment of multiple myeloma and mantle cell lymphoma.

How it works

Bortezomib in Bortero 2mg Injection works by exerting a toxic effect on cancer cells. It inhibits the 26S proteasome and blocks a major cell signaling pathway. This inhibition of the signaling pathway makes the cancer cells sensitive to chemotherapy. This medicine also enhances the build-up of a protein and minimizes cancer cell growth and multiplication.

How to Use

Bortero 2mg Injection is administered intravenously or subcutaneously. This injection should be given by a qualified healthcare professional experienced in the use of cytotoxic medications. Do not self-administer.

Side Effects

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Serious Muscle cramps Confusion, visual disturbances, seizures, and headache Breathlessness Swelling of feet Changes in heartbeat High blood pressure Fainting and tiredness Cough and chest tightness Common Pneumonia Loss of appetite Sensitivity, tingling and burning sensation of the skin Nausea, vomiting, and diarrhea Mouth ulcers Constipation Muscle and bone pain Hair loss Fever Reduction in blood cell count Reduced kidney function Shivering Infections Itching and redness Dehydration Stomach problems Difficulty sleeping, anxiety, mood swings, depressed mood

Expert Tips

It is advised that both men and women must use an effective contraception method during treatment and three months afterward. Treatment with Bortero 2mg Injection can commonly cause a decrease in the number of red and white blood cells and platelets in your blood. Therefore, you will have to take regular blood tests before and during your treatment with bortezomib to check your blood cell counts regularly. Pregnant women should not handle this Injection as it contains cytotoxic agents. Using gloves and protective clothing is recommended to prevent skin contact.

References

  1. STADA, Electronic Medicines Compendium (EMC), [Revised on Nov 2021] [Accessed on 30 Nov 2022], https://www.medicines.org.uk/emc/files/pil.10201.pdf
  2. Takeda Pharmaceuticals U.S.A., Inc., [Revised on Aug 2022] [Accessed on 30 Nov 2022], https://www.velcade.com/files/pdfs/VELCADE_PRESCRIBING_INFORMATION.pdf
  3. Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.
  4. KD Tripathi, Anticancer Drugs, Essentials of Medical Pharmacology, 8th Edition, 2019, 915-936.
  5. H.G. Watson, J.I.O. Craig, L.M. Manson, Blood disease, Davidson’s Principles and Practice of Medicine, 22nd Edition, 2014, 989-1056

Safety Advice

Pregnancy: unsafe Bortero 2mg Injection is unsafe to use during pregnancy unless clearly necessary. Both women of childbearing potential and men must use an effective contraception method during and three months after treatment.

Lungs: Consult your doctor It is unknown whether Bortero 2mg Injection can be given to lung failure patients. Please consult your physician if you have any lung diseases.

Breastfeeding: unsafe Bortero 2mg Injection is unsafe to use during breastfeeding. Please discuss with your physician when it is safe to restart breastfeeding after this treatment.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS