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Bufatas IV 60mg Injection

Salt Composition: BUSULFAN

₹5002.00₹11632.50

Inclusive of all taxes

Categories: Oncology

Conditions: Anti Cancer

Product Introduction

Bufatas IV 60mg injection is an anti-cancer (antineoplastic/cytotoxic) chemotherapy drug. It is an alkyl sulfonate belonging to the class of alkylating agents. It is indicated for treating blood cancers, such as chronic myelogenous leukemia (a type of cancer that causes an increase in white blood cells). It is given as a treatment to prepare the bone marrow to receive healthy blood-forming cells (stem cells) from a donor to replace stem cells that have been destroyed by treatment with radiation or high doses of chemotherapy. Chronic myelogenous leukemia is an uncommon type of cancer that affects bone marrow (soft, spongy tissue that produces blood cells for your body). It causes an increase in white blood cell count. Common side effects of Bufatas IV 60mg injection are decreased white blood cell count, dizziness, shortness of breath, mouth inflammation, nausea, diarrhoea, difficulty sleeping, skin rashes, and fever. Drink plenty of fluids while you are taking this medicine. Bufatas IV 60mg injection can cause a severe decrease in bone marrow activity. If you are taking any other prescribed or non-prescribed medications that decrease the blood cell count, talk to your healthcare professional before taking these medications. It affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, cough, mouth sores, or unusual bleeding or bruising.

Uses

Hematopoietic progenitor cell transplantation Chronic myelogenous leukemia Polycythaemia vera (a type of cancer that causes an increase in red blood cells) Thrombocythemia (increased number of platelets in the blood) Myelofibrosis (type of blood cancer where scar tissues are formed in bone marrow) Hemoglobinopathies (a genetic disorder that produces abnormal hemoglobin) Brain Malignancies

How it works

Bufatas IV 60 mg injection works by interfering with the DNA replication process, which is necessary for the cells to divide. It stops tumor growth by inhibiting cell division. It causes cytotoxicity by reversibly binding to nucleophilic groups on different cell components. Alkylation of DNA is most likely the crucial cytotoxic reaction that kills tumor cells. It damages the DNA and RNA of the cancer cells by stopping their growth and multiplication. They are combined with other medications to treat various lymphatic and solid cancers.

How to Use

Your physician will decide the formulation, dose, and duration of this therapy. The dose of Bufatas IV 60 mg injection depends on your blood cancer. If you are prescribed the injection, your healthcare professional will administer the injection. Do not self-administer. The injection is administered as an intravenous infusion into the vein. Don't stop the medication until or unless your doctor advises. If you missed the dose, do not take double the doses. Inform your physician about your missed dose.

Side Effects

Side effects are unwanted symptoms caused by medicines. Even though all medications cause side effects, not everyone gets them. Bufatas IV 60 mg injection causes the following side effects Severe Myelosuppression (decreased bone marrow activity) Common side effects Thalassemia Skin rashes Hair loss Patches of dark skin Blood in urine Decrease in the number of blood cells and platelets Nausea and vomiting Jaundice Infertility and sterility Pneumonia Syndrome Itching

Expert Tips

Inform the doctor if the patient has taken radiotherapy priorly to the treatment. If you have any other medical conditions like heart disease, lung, kidney, or liver problems. Tell your doctor if you have any symptoms of gout (pain and swollen joints caused by uric acid crystals). During or after administration of the injection, if you face itchy skin, fever, excessive sweating, rigors or chills, or difficulty in breathing, inform your doctor immediately.

References

  1. Aspen, Electronic Medicines Compendium(EMC) (Revised on: July 2020) https://www.medicines.org.uk/emc/product/4653/pil#gref (Accessed: December 14, 2022).
  2. Busulfan (Revised on: May 19, 2015) National Cancer Institute . https://www.cancer.gov/about-cancer/treatment/drugs/busulfan (Accessed: December 14, 2022).
  3. Anton Wellstein, Giuseppe Giaccone, Michael B. Atkins, and Edward A. Sausville, Pharmacotherapy of Neoplastic disease: cytotoxic drugs, Goodman & Gilman’s Pharmacological Basis of Therapeutics, 13th Edition, 2018, 1167-1174.
  4. Buggia I, Locatelli F, Regazzi MB, Zecca M. Busulfan. Ann Pharmacother. 1994 Sep;28(9):1055-62. doi: 10.1177/106002809402800911. PMID: 7803883.

Safety Advice

Pregnancy: unsafe If you are pregnant or planning to get pregnant, ask your doctor or pharmacist for advice before taking this medicine. This medicine can cause infertility. It applies to men and women because Bufatas IV 60 mg injection may harm your sperm or eggs. It may have harmful effects on your baby.

Lungs: Consult your doctor It is unknown whether Bufatas IV 60mg Injection can be given to patients with lung diseases. Please inform your doctor if you have any lung problems.

Breastfeeding: unsafe If you are breastfeeding or plan to breastfeed your baby, talk to your physician because the drug may secrete in breast milk.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS