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Cizumab 400mg Injection

Salt Composition: BEVACIZUMAB

₹10000.00₹52800.00

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Cizumab 400mg Injection

Categories: Oncology

Conditions: Anti Cancer

Product Introduction

Cizumab 400mg Injection is an anticancer medicine containing the active ingredient Bevacizumab. This medicine is designed to inhibit tumour growth. It is indicated in combination with other chemotherapy drugs for treating metastatic breast cancer, brain cancer, cervical cancer, kidney cancer, lung cancer, and colorectal cancer. It is also used for cancers of the ovary, fallopian tube, and primary peritoneal cancer. Effective birth control should be used during treatment and for at least six months after the final dose. Cizumab 400mg Injection is not recommended for children and adolescents under 18 years of age. Discuss with your doctor about ovarian preservation if you are planning pregnancy in the near future, as this medicine may cause fertility issues in women. Breastfeeding should be avoided as this medicine may interfere with infant growth and development. Cizumab 400mg Injection is commonly administered in combination with other chemotherapy agents. Constipation, loss of appetite, rhinorrhoea, fever, skin problems, and weight loss are common side effects of Cizumab 400mg Injection. Before beginning treatment with this medicine, inform your doctor if you have high blood pressure, high blood glucose, gastrointestinal disorders, or cardiac problems. This medicine should not be used for 28 days before and after surgery due to the risk of impaired wound healing and increased bleeding complications. Report to your doctor if you have any dental conditions requiring surgical intervention before commencing this medicine. Notify your doctor immediately if you experience any visual changes or confusion to prevent further complications.

Uses

Cizumab 400mg Injection is indicated to treat the following conditions: Glioblastoma multiforme (brain cancer) Persistent, recurrent, or metastatic breast cancer Metastatic cervical cancer Advanced kidney cancer Metastatic colorectal cancer Advanced non-small-cell lung cancer Liver Cancer- Hepatocellular carcinoma Cancers of the ovary, cervical, fallopian tube, or primary peritoneal cancer

How it works

Cizumab 400mg Injection is a recombinant humanized monoclonal antibody that works as a targeted therapy in the treatment of various advanced cancers. It produces its action by selectively binding to the protein called vascular endothelial growth factor A (VEGF-A), present in the lining of blood and lymph vessels in the body. It interrupts the interaction of VEGF-A with its receptors. This further inhibits the formation of blood vessels that supply oxygen and nutrients to the tumor. As a result, it slows down the rate of progression of cancer.

How to Use

Your physician or nurse will administer Cizumab 400mg Injection as an intravenous infusion. The infusion should be given immediately after the dilution.

Side Effects

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them. Serious: Headache Vision changes Confusion Severe allergic reactions High Blood pressure Delayed wound healing following surgery Protein in urine Severe infections Blood clots in arteries and blood vessels of lungs Gut perforation Nosebleeds and bleeding risk Heart problems with an increase in heart rate Mouth sores, dryness Shortness of breath Common: Numbness in hands or feet Weakness and lack of energy Diarrhoea, nausea, vomiting, abdominal pain Constipation Loss of appetite Weight loss Changes in taste and speech Decrease in counts of white blood cells Fever Dry skin Back pain

Expert Tips

It is vital to inform your physician before taking Cizumab 400mg Injection if you have the following conditions: Have conditions involving inflammation in the stomach (ulcer, colitis). Experience allergic reactions to Cizumab 400mg Injection or its ingredients. Have recently undergone surgery as it is associated with the risk of bleeding. Have diabetes, hypertension, or heart problems.

References

  1. 1. Roche Products Limited, Electronic Medicines Compendium (EMC), [Revised on Jan 2022] [Accessed on 21/11/2022], https://www.medicines.org.uk/emc/files/pil.3885.pdf 2. G.G. Dark, A.R. Abdul Razak, Oncology, Davidson's Principles & Practice of Medicine, 22nd Edition, 2014, 259-282. 3. KD Tripathi, Anticancer Drugs, Essentials of Medical Pharmacology, 8th Edition, 2019, 915-936. 4. Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976. 5. Roche Group, U.S FDA, [Revised on Jan 2021][ Accessed on 21/11/2022], https://www.gene.com/download/pdf/avastin_prescribing.pdf 6. Roche Group,Bevacizumab Injection, Indication,[Revised on 2020] [Accessed on 21/11/2022] https://www.avastin.com/patient/mcrc.html

Safety Advice

Pregnancy: unsafe Inform your physician before starting your treatment with Cizumab 400mg Injection in case, if you are pregnant or planning for pregnancy as this medicine may cause harm to the unborn baby and interrupt the formation of blood vessels.

Lungs: Consult your doctor Inform your doctor if you have any lung conditions before starting treatment with Cizumab 400mg injection

Breastfeeding: unsafe It is recommended to avoid breastfeeding for a minimum of 6 months after your treatment with Cizumab 400mg Injection as this medicine may interfere with the growth of your child.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS