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Cladrim 10mg Injection
Salt Composition: CLADRIBINE
- Manufacturer: FRESENIUS KABI INDIA PVT LTD
- Pack Size: 1 VIAL(s) OF 10ML
- Dosage Form: INJECTION
- Strength: 10MG
- Prescription Required
- Cold Chain
- Prepaid Only. Non-Returnable.
- Storage: Store Cladrim injection in a refrigerator at (2°C to 8°C). Keep it out of reach from children.
₹9891.00₹12362.00
Inclusive of all taxes
Product Introduction
Cladrim 10mg injection is an antineoplastic drug belonging to the category of purine analogues, containing the active ingredient cladribine. It is used in the treatment of multiple sclerosis, an autoimmune disorder affecting the nervous system. It is also used to treat hairy cell leukaemia, a cancer of white blood cells.
Cladrim is contraindicated in patients with current malignancies, active chronic infections such as tuberculosis or hepatitis, and in those with a history of hypersensitivity reactions. High doses have been associated with irreversible neurologic toxicity (paraparesis/quadriparesis), acute nephrotoxicity, and severe bone marrow suppression resulting in neutropenia, anaemia and thrombocytopenia.
Clinicians should monitor patients frequently for signs and symptoms of neurological impairment, including numbness or tingling in the arms or legs, weakness, or loss of bowel or bladder control. If these symptoms occur, urgent treatment is necessary to prevent further neurological damage.
It is essential to inform your doctor if you have a history of bleeding disorders, liver or kidney disease, or if you are taking any other medications, including over-the-counter drugs, supplements, or herbal remedies.
Cladrim 10mg injection is not recommended for pregnant women as it may cause fetal harm. Your healthcare practitioner will conduct a pregnancy test before you start treatment. The injection may cause birth defects if either partner uses it during conception or pregnancy. Male patients with female partners of reproductive potential should use effective birth control during treatment and for 3 months after the last dose. Do not breastfeed during treatment and for 10 days after the last dose.
Avoid vaccination with live-attenuated or live vaccines during and after treatment with this drug while the patient's white blood cell counts are not within normal limits. Cladrim 10mg injection price varies based on the seller and location.
Uses
cladrim injection uses : Multiple sclerosis Hairy cell leukaemia
How it works
Cladrim 10mg injection is a chemotherapy medication primarily used in the treatment of certain cancers, such as chronic lymphocytic leukaemia (CLL) and non-Hodgkin's lymphoma. Its therapeutic effects stem from its ability to inhibit DNA synthesis, which helps prevent the growth and division of cancerous cells. By targeting rapidly dividing cells, Cladrim works to reduce tumour size and control the spread of cancer. Additionally, it can be used to treat other conditions involving abnormal cell growth, providing significant therapeutic benefits when other treatments are less effective. However, due to its powerful effects, Cladrim is typically administered under careful medical supervision to monitor for potential side effects.
Side Effects
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Serious Septic shock (infection throughout the body) Malignancies Anemia Renal failure Bleeding Depressed level of consciousness Neurotoxicity Infection Common Low white blood cells Allergic reactions Administration site reaction Confusion, Anxiety, Insomnia Headache, dizziness Eye infection Abnormal heart rate Cough, abnormal breath sounds Nausea, vomiting Abdominal pain, constipation, diarrhea Buildup of gas Rash, itchiness Chills Loss of appetite Pain, joint pain Fatigue, muscle weakness Swelling in the hands and feet Inflammation of vein
Expert Tips
Avoid contact with people who have infections, especially during the time when you are taking the medication. Limit direct skin contact with the tablets, and wash exposed areas thoroughly. Your doctor will perform regular blood tests during treatment with this drug to monitor the blood cell counts and kidney function. Let your doctor know about any other medications you are taking, including over-the-counter drugs, supplements, or herbal remedies.
References
- Merck See Ltd, Electronic medicines compendium (emc), [ Revised on Aug 2020], https://www.medicines.org.uk/emc/product/8435/pil [ Accessed on 15th April 2023].
- Highlights of prescribing information ... - food and drug administration. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/022561s000lbl.pdf [ Accessed on 15th April 2023].
- Ema (2022) Mavenclad, European Medicines Agency. Available at: https://www.ema.europa.eu/en/medicines/human/EPAR/mavenclad [ Accessed on 15th April 2023].
- SAHPRA Medicines Available at: https://pi-pil-repository.sahpra.org.za/wp-content/uploads/2023/01/530218_Final_PIL_Mavenclad-10-mg_Applicant.pdf [ Accessed on 15th April 2023].
- Cladribine injection warnings - pfizer. Available at: https://cdn.pfizer.com/pfizercom/products/uspi_cladribine.pdf [Accessed on 15th April 2023].
- Goodman & Gilmanâs, The Pharmacological Basis of Therapeutics, Cytotoxic agents, 12th edition, 2011, 1703-1704.
Safety Advice
Pregnancy: unsafe Cladrim 10mg injection is not recommended for pregnant women as it may cause fetal harm. Consult your doctor if you are pregnant or planning for pregnancy during the treatment.
Lungs: Consult your doctor Inform your doctor if you have any lung problems before taking Cladrim 10mg injection.
Breastfeeding: Consult your doctor It is not known if Cladrim 10mg injection passes into your breast milk or if it will affect your baby. Please consult your doctor before breastfeeding.
Disclaimer
The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.