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Crizalk 200mg Capsule
Salt Composition: CRIZOTINIB
- Manufacturer: PFIZER LTD
- Pack Size: 60 CAPSULE(s) IN A BOX
- Dosage Form: CAPSULE
- Strength: 200MG
- Prescription Required
- Storage: Store at room temperature (15-30ËC) in the original container Keep this medicine out of the sight and reach of children.
₹78384.00₹100490.57
Inclusive of all taxes
Product Introduction
Crizalk 200mg contains the active substance crizotinib. It is an antineoplastic drug belonging to the class of tyrosine kinase inhibitors. This medicine is prescribed to treat patients with anaplastic lymphoma kinase (ALK) positive non-small cell lung cancer (NSCLC) that is locally advanced or metastatic (spread outside the lungs or to other parts of the body). Do not take this capsule if you are allergic to crizotinib or any other ingredients of this medicine. Before initiating treatment, inform your doctor if you have had kidney, stomach, heart, or liver problems. Notify your doctor if you have reduced white blood cells, abnormal heart tracing on ECG, vision problems, or if you take other medications. Report to your doctor immediately if you are planning to get pregnant or think you may be pregnant. Discuss effective contraceptives with your doctor. Use effective birth control during treatment because oral contraception is ineffective with this medicine, and use it for at least 90 days even after completing therapy with Crizalk 200mg capsule. It is advised to discuss fertility concerns with your doctor. This medication is not recommended for adolescents and children under 18 years of age. Use sunscreen or protective clothing to cover the skin and protect it against sunburn. Crizalk substitutes include xalkori, alectinib, ceritinib, lorlatinib, and brigatinib, which are also used for ALK-positive non-small cell lung cancer.
Uses
Crizalk 200mg tablet uses are: Anaplastic lymphoma kinase (ALK) positive non-small cell lung cancer (NSCLC)
How it works
Crizotinib is a tyrosine kinase inhibitor that works by blocking the activity of the anaplastic lymphoma kinase (ALK) protein. It specifically targets the abnormal protein and blocks its activity, slowing down or stopping the growth and spread of cancer cells.
How to Use
Take the Crizalk 200mg capsules at about the same time each day. The recommended dose is one capsule of 250 mg taken orally twice daily. Swallow the capsules whole and do not crush, chew, dissolve, or open the capsules. Your physician will choose the Crizalk dosage and administration frequency based on the medical condition because it differs for each person.
Side Effects
Crizalk 200mg side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Serious Pain on the right of the stomach Partial or full loss of vision Lowered WBC Low heart rate. Swelling of the lungs. Breathlessness Cough with or without mucus Common Sensitivity to sunlight. Diarrhea Fever Constipation Nausea Increased liver enzymes Decreased appetite Tiredness (fatigue) Dizziness Neuropathy (weakness, tingling, or numbness in the nerve) Dysgeusia ( taste disorder) Hypophosphataemia (low levels of phosphate in the blood)
References
- David Eric Gerber, ECOG-ACRIN Cancer Research Group, ClinicalTrials.gov IDNCT02201992 [Accessed on 30th Mar 2021],
- https://www.cancer.gov/about-cancer/treatment/clinical-trials/search/v?id=NCI-2014-01507&r=1
- Pfizer, Electronic Medicines Compendium (EMC), [Revised on Jun 2022], [Accessed on 19th April 2023], ANNEX I (medicines.org.uk)
- Anton Wellstein, Giuseppe Giaccone, Michael B. Atkins, and Edward A. Sausville, Pathway-Targeted Therapies: Monoclonal Antibodies, Protein Kinase Inhibitors, and Various Small Molecules, Goodman & Gilmanâs Pharmacological Basis of Therapeutics, 13th Edition, 2018, 1203-1236.
Safety Advice
Pregnancy: unsafe Crizalk 200mg capsule is unsafe to use during pregnancy. Hence, check with your physician before taking this medicine if you are pregnant or think you might be pregnant.
Lungs: Consult your doctor Inform your doctor immediately if you experience any symptoms like lung inflammation, difficulties in breathing, cough with or without mucous, or even fever while taking Crizalk 200mg capsule.
Breastfeeding: unsafe It is unsafe to breastfeed while taking Crizalk 200mg capsule because it can cause toxicity to the baby. Consult your physician for more information.
Disclaimer
The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.