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Darb-ESA 25mcg Injection

Salt Composition: DARBEPOETIN ALFA

₹1275.00₹1592.81

Inclusive of all taxes

Categories: Nephrology

Conditions: Kidney Disease

Product Introduction

Darb-ESA 25mcg injection is an antineoplastic medication belonging to the class of hematopoietic growth factors. The active ingredient is Darbepoetin Alfa. It is used to treat anaemia in patients with chronic kidney disease and anaemia caused by chemotherapy in patients with certain types of cancer.

Darbepoetin Alfa should not be used if you are allergic to the active compound or any other ingredient in this medicine. Complete blood count monitoring is recommended before starting therapy. Use is not recommended in patients with uncontrolled blood pressure or in those receiving cancer treatment with hormonal drugs and radiotherapy. It should not be used in place of red blood cell transfusions in patients requiring immediate anaemia correction.

Inform your physician if you have high blood pressure, anaemia, a history of seizures, epilepsy, liver disease, or allergy to latex or hepatitis C. Inform your physician if you are pregnant or breastfeeding. Before initiating treatment, inform your physician if you have fever, blood clots, any infections, or kidney, heart or liver problems.

Your doctor will monitor your haemoglobin levels to ensure they remain within a specified range. High haemoglobin concentrations can increase the risk of developing heart or blood vessel problems. Inform your physician about all medicines, over the counter drugs, vitamins and herbal supplements you are taking before starting therapy.

Uses

To treat anemia in chronic kidney failure To treat anemia caused by chemotherapy

How it works

Darb-ESA 25mcg injection is an erythropoiesis-stimulating protein produced by recombinant DNA technology. The erythropoietin receptor on the surface of erythroid progenitor cells in the bone marrow is bound by Darb-ESA 25mcg injection and activated. This activation sets off a signaling cascade that increases the erythroid progenitor cells' ability to survive, proliferate, and differentiate, ultimately increasing the generation of red blood cells.

How to Use

The injection is to be administered subcutaneously, or beneath the skin. Your doctor will provide you instruction on how to use this pre-filled pen for self-injection. If you are not well-trained, do not attempt to inject the pre-filled pens. Never put the medication intravenously. Visit the hospital or clinic in the area if you require assistance administering the medication. The dosage and frequency of Darb-ESA 25mcg injection will depend on various factors, including the patient's age, weight, overall health and condition being treated. It's important to follow the dosing instructions provided by a healthcare provider, and not to adjust the dosage or frequency without consulting with them first. If a dose is missed, it should be taken as soon as possible unless it's within 6 hours of the next scheduled dose. In that case, the missed dose should be skipped and the regular dosing schedule resumed.

Side Effects

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Common Swelling in the face and body Low blood pressure Abdominal pain Shortness of breath cough Serious Heart problems Severe skin reactions Anemia Seizure attack Lung problems

Expert Tips

You will be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to. Do not shake the vial or syringe. You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. You should stay well-hydrated, maintain a healthy diet rich in iron and other nutrients, and avoid activities that may increase your risk of injury or bleeding. It is recommended to monitor your blood counts at regular intervals. Eat less foods that contain high-sodium such as packaged snacks, canned soups, processed meats, and fast food, as too much salt can cause hypertension and fluid retention. Remember to attend all scheduled appointments and follow-up visits with your healthcare provider to ensure your treatment is effective and any side effects are managed appropriately.

References

  1. Amgen Limited, Electronics Medicines Compendium(emc), [ Revised on March 2022] [ Accessed on March 2024], https://www.medicines.org.uk/emc/files/pil.7993.pdf
  2. Amgen Inc, United States Food and Drug Administration (US FDA), [ Revised on July 2015] [ Accessed on March 2024], https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/103951s5363lbl.pdf
  3. Amgen Inc, [Revised on January 2019], [Accessed on March 2024], https://www.pi.amgen.com/-/media/Project/Amgen/Repository/pi-amgen-com/aranesp/ckd/aranesp_pi_hcp_english.pdf

Safety Advice

Pregnancy: Consult your doctor There are no adequate and well-controlled studies on the use of Darb-ESA 25mcg injection in pregnant women. Inform your physician if you are pregnant, suspecting, or planning for pregnancy during the treatment.

Lungs: Consult your doctor It is unknown whether Darb-ESA 25mcg injection can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.

Breastfeeding: unsafe Darb-ESA 25mcg injection is not recommended during breastfeeding, as it is unknown if Abemaciclib is excreted in human milk. Because of the potential risk to the infant, breastfeeding is not recommended.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS