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Darzalex 100mg Injection

Salt Composition: DARATUMUMAB

₹13623.00₹16025.89

Inclusive of all taxes

Categories: Oncology

Conditions: Anti Cancer

Product Introduction

Darzalex 100mg injection is a targeted therapy containing the active ingredient Daratumumab, a monoclonal antibody. Monoclonal antibodies are proteins that recognise and attach to specific targets on cancer cells, leading to their destruction. It is indicated for the treatment of multiple myeloma in adults aged 18 years and older.

Report to your doctor if you have a history of hepatitis B infection, as this medicine may cause reactivation of the hepatitis B virus. Darzalex can reduce platelet counts (which aid blood clotting) and white blood cell counts (which help fight infections). Do not use this medicine if you are allergic to Daratumumab or any other ingredient in the formulation.

This medicine is not recommended for use in children and adolescents. Inform your doctor immediately if you experience infusion-related reactions, such as swelling of the face, lips, mouth, tongue, or throat. If infusion reactions occur, you may require additional medication, or the infusion rate may be reduced or discontinued.

Advise your doctor if you follow a salt-restricted diet, as this medicine contains sodium. Inform your healthcare provider if you have a history of breathing problems (asthma or chronic obstructive pulmonary disease) or previous shingles infection before commencing treatment.

This medicine can alter blood test results used for blood typing. You must inform your healthcare provider that you are being treated with this medicine prior to receiving any blood transfusion. Notify your doctor if you are pregnant or planning pregnancy. Effective contraception should be used during treatment and for three months after completion.

Uses

The darzalex injection uses include: Treatment of Multiple myeloma

How it works

Darzalex 100mg binds specifically to a protein called CD38 found on the surface of multiple myeloma cells. This binding can trigger the immune system to attack and kill the cancer cells.

How to Use

A trained doctor or nurse should only administer Darzalex 100mg. Do not self-administer the injection. Your doctor will decide the dose and duration of your treatment based on the disease severity and other factors. It will be given as an intravenous infusion, and you will be monitored carefully for unwanted side effects.

Side Effects

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them. The darzalex injection side effects include: Serious side effects of Darzalex 100mg Injection are: Infusion reactions (itching, wheezing, chills, fever, throat tightness, runny nose, headache, low pressure) Changes in blood tests Decrease in blood cell counts Common side effects of Darzalex 100mg Injection are: Nausea, vomiting Back pain, muscle spasms Diarrhea Tiredness Shortness of breath Upper respiratory tract infection Tingling, numbness, or pain Constipation Trouble sleeping Dizziness

Expert Tips

If you experience any symptoms mentioned above, consult your doctor immediately. While undergoing treatment, use effective contraception and continue it for three months after stopping treatment. Darzalex 100mg is not recommended for children and adolescents under 18 years. Do not freeze the medicine. Before starting the treatment, inform your doctor about every underlying medical condition. Talk to your physician if you are on a salt-controlled diet, as this medicine contains sodium.

References

  1. Janssen-Cilag International NV, Electronic medicines compendium (EMC), [ Revised on Feb 2023] [ Accessed on 1 May 2023], https://www.medicines.org.uk/emc/files/pil.7250.pdf
  2. Janssen Biotech, Inc, US Food and Drug Administration, [ Revised on May 2018] [ Accessed on 1 May 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/761036s013lbl.pdf
  3. Danai Dima et al.; Evaluating Daratumumab in the Treatment of Multiple Myeloma: Safety, Efficacy, and Place in Therapy; Cancer Management and Research; Published on 26/08/2020; Accessed on 1 May 2023; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457558/

Safety Advice

Pregnancy: Consult your doctor Your doctor will prescribe Darzalex 100mg only if needed, as this medicine might cause harm to the unborn baby. So notify your doctor before starting the preganat if you are preganat or planning to get pregnant. Use effective contraception during and after the treatment for three months.

Lungs: Consult your doctor It is unknown whether Darzalex 100mg is safe for patients with lung problems. Inform your physician if you have any lung disease before starting the treatment. Contact your doctor if you experience any lung-related symptoms, such as difficulty breathing.

Breastfeeding: Consult your doctor It is unknown whether Darzalex 100mg is safe to administer in breastfeeding patients. Before starting the treatment, notify your doctor if you are breastfeeding.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS