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Denoci 60mg Injection

Salt Composition: DENOSUMAB

₹7969.00₹15468.75

Inclusive of all taxes

Denoci 60mg Injection

Categories: Rheumatology

Conditions: Arthritis

Product Introduction

Denoci 60 mg Injection contains denosumab as its active ingredient and is used to treat osteoporosis, a condition that weakens bones and increases the risk of fractures. It is also indicated for preventing bone-related complications in patients with cancers that affect the bones, including bone metastases, multiple myeloma, and certain primary bone cancers. In addition, it is an established treatment option for giant cell tumor of the bone.

Denoci 60 mg Injection works by inhibiting RANK ligand, a protein involved in the formation and activity of bone-resorbing cells. By blocking this protein, the medicine slows bone breakdown, increases bone mineral density, and lowers the risk of fractures, particularly in postmenopausal women and individuals with cancer-related bone disease.

Patients receiving this treatment should ensure adequate intake of calcium and vitamin D, as recommended by their healthcare provider, to reduce the risk of low blood calcium levels. The safety and effectiveness of Denoci 60 mg Injection have not been established in children and adolescents; therefore, its use is generally not recommended in these age groups. Individuals with hypoparathyroidism or low parathyroid hormone levels should use this medicine with caution and under close medical supervision.

Common side effects may include low calcium levels, bone or joint pain, and skin reactions. Patients with moderate kidney impairment may require regular monitoring during treatment, as they may be at a higher risk of developing complications related to calcium balance.

Uses

Denoci 60mg uses are in the treatment of the following condition: Osteoporosis Bone loss due to hormonal therapy in breast or prostate cancer Multiple myeloma (cancer affects plasma cells in the bone marrow) Bone metastases (cancer that spreads to bone).

How it works

Denoci 60mg injection has therapeutic effects that include reducing fracture risk, increasing bone mineral density, and improving overall bone health. By inhibiting bone resorption through its action on RANK ligands, this medication helps to strengthen bones and decrease the likelihood of fractures in individuals with osteoporosis or those at high risk. It also increases bone mineral density, an important marker of bone strength. These therapeutic effects contribute to improved bone health and a reduced risk of fractures, ultimately enhancing the quality of life for patients.

Side Effects

Denoci 60mg injection side effects like all medications, although not everyone who takes it will experience them. Denoci 60mg side effects are Serious: Osteonecrosis of the jaw (severe necrosis or death of jaw cells) Atypical femoral fractures Hypocalcemia (low blood calcium levels) Common: Injection site reactions Back pain Musculoskeletal pain Infections Abdominal pain Headache Hypophosphatemia (low blood phosphate levels)

Expert Tips

Attend all scheduled appointments and follow-up visits to monitor treatment response and manage any side effects. Share your complete medical history with your doctor, including previous infections, liver disease, or kidney disease. Inform your healthcare provider about any allergies or hypersensitivity reactions. Seek immediate medical help if you experience severe allergic reactions or other serious side effects. Be aware that Denoci 60mg injection may affect calcium levels, regular monitoring and adequate calcium and vitamin D intake are important. Pregnant and breastfeeding women should consult a doctor before using this medication. Avoid taking any vaccines during the course of treatment. Maintain regular dental check-ups and good oral hygiene to lower the risk of jaw osteonecrosis.

References

  1. Amgen Ltd, Electronic medicines compendium (EMC), [ Revised on 13th May 2023], [ Accessed on 31st May 2023], https://www.medicines.org.uk/emc/files/pil.568.pdf
  2. Amgen Manufacturing Limited, US Food and Drug Administration, [ Revised on November 2010] [ Accessed on 31st May 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/125320s007lbl.pdf
  3. Amgen Manufacturing Limited, US Food and Drug Administration, [ Revised on November 2022] [ Accessed on 31st May 2023], https://www.fda.gov/media/163378/download

Safety Advice

Pregnancy: Consult your doctor The safety of using Denoci 60mg injection during pregnancy has not been established. Limited studies are available regarding the use of this medication in pregnant women, so it is recommended to use caution and consult a doctor before considering its use during pregnancy.

Lungs: Consult your doctor If you have a lung or respiratory disorders history, it is important to consult your healthcare provider before taking Denoci 60mg injection.

Breastfeeding: Consult your doctor Whether Denoci 60mg injection is excreted in milk is unknown. So it is better to consult a healthcare provider if you are a breastfeeding mother before taking this medication.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS