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Denotec 120mg Injection

Salt Composition: DENOSUMAB

₹9450.00₹26999.00

Inclusive of all taxes

Categories: Rheumatology

Conditions: Arthritis

Product Introduction

Denotec 120mg Injection contains the active ingredient Denosumab. It is prescribed to treat osteoporosis, a condition characterised by weakened bones. It is also used to prevent bone complications in patients with certain types of cancer, including multiple myeloma and bone metastases. Denosumab 120mg Injection works by inhibiting RANK ligand, which is involved in bone breakdown. Clinical evidence demonstrates that it can substantially increase bone density, reducing fracture risk in postmenopausal women with osteoporosis and patients with cancer-related bone loss. Monitoring of renal function may be required for patients with moderate renal impairment. Denotec 120mg Injection should not be used in individuals with known hypersensitivity or allergic reactions to its components. Adequate calcium and vitamin D supplementation is necessary during treatment. It is not approved for use in children and adolescents. Safety and effectiveness in paediatric populations have not been established, making its use contraindicated in individuals under 18 years of age. This medication should be used with caution in individuals with pre-existing hypoparathyroidism, characterised by low parathyroid hormone levels.

Uses

Denotec Injection uses for the treatment of the following conditions: Osteoporosis Bone loss due to hormonal therapy in breast or prostate cancer Multiple myeloma (cancer affects plasma cells in the bone marrow) Bone metastases (cancer that spreads to bone)

How it works

Denotec 120mg Injection has therapeutic effects, including reducing fracture risk, increasing bone mineral density, and improving overall bone health. By inhibiting bone resorption through its action on RANK ligands, this medication helps to strengthen bones and decrease the likelihood of fractures in individuals with osteoporosis or those at high risk. It also increases bone mineral density, an important marker of bone strength. These therapeutic effects improve bone health and reduce the risk of fractures, ultimately enhancing patients' quality of life.

How to Use

Denotec 120mg Injection is administered by healthcare professionals. The denotec 120 mg dosage and treatment duration will be based on the individual's condition and response to the medication and should be determined by a healthcare provider.

Side Effects

Denotec 120 mg Injection side effects are like all medications, although not everyone who takes it will experience them. Serious : Osteonecrosis of the jaw (severe necrosis or death of jaw cells) Atypical femoral fractures Hypocalcemia (low blood calcium levels) Common : Injection site reactions Back pain Musculoskeletal pain Infections Abdominal pain Headache Hypophosphatemia (low blood phosphate levels)

Expert Tips

Attend all scheduled appointments and follow-up visits to monitor your response to treatment and manage any side effects. Inform your doctor about your medical history, including previous infections, liver disease, kidney disease, or any allergies. Seek immediate medical attention if you experience severe allergic reactions or other serious side effects. This injection may affect calcium levels, so regular monitoring and adequate calcium and vitamin D intake are important. Pregnant or breastfeeding women should consult a doctor before using this medicine and avoid taking vaccines during treatment. Maintain good oral hygiene and have regular dental check-ups to reduce the risk of jaw osteonecrosis.

References

  1. Amgen Ltd, Electronic medicines compendium (EMC), [ Revised on 13th May 2023], [ Accessed on 31st May 2023], https://www.medicines.org.uk/emc/files/pil.568.pdf
  2. Amgen Manufacturing Limited, US Food and Drug Administration, [ Revised on November 2010] [ Accessed on 31st May 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/125320s007lbl.pdf
  3. Amgen Manufacturing Limited, US Food and Drug Administration, [ Revised on November 2022] [ Accessed on 31st May 2023], https://www.fda.gov/media/163378/download

Safety Advice

Pregnancy: Consult Your Doctor The safety of using Denotec 120mg Injection during pregnancy has not been established. Limited studies are available regarding the use of this medication in pregnant women, so it is recommended to use caution and consult a doctor before considering its use during pregnancy.

Lungs: Consult Your Doctor If you have a history of lung or respiratory disorders, it is important to consult your healthcare provider before taking Denotec 120mg Injection.

Breastfeeding: Consult Your Doctor Whether Denotec 120mg Injection in milk is unknown. So it is better to consult a healthcare provider if you are a breastfeeding mother before taking this medication.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS