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Denu 60mg Injection

Salt Composition: DENOSUMAB

₹6469.00₹8085.90

Inclusive of all taxes

Categories: Rheumatology

Conditions: Arthritis

Product Introduction

Denu 60mg Injection contains the active ingredient Denosumab. It is prescribed to treat osteoporosis, a condition characterised by weakened bones. It is also used to prevent bone complications in patients with certain types of cancer, including multiple myeloma and bone metastases. Denu 60mg Injection functions by inhibiting RANK ligand, a protein involved in bone tissue breakdown. Clinical evidence demonstrates that it can significantly increase bone density, reducing fracture risk in postmenopausal women with osteoporosis and patients with cancer-related bone loss. Monitoring of renal function may be necessary for patients with moderate renal impairment. Denu 60mg Injection is contraindicated in individuals with known hypersensitivity or allergic reactions to its components. Adequate calcium and vitamin D supplementation is required during treatment. It is not approved for use in children and adolescents. Safety and effectiveness in paediatric populations have not been established, making its use contraindicated in individuals under 18 years of age. This medication should be used with caution in individuals with pre-existing hypoparathyroidism, characterised by low parathyroid hormone levels.

Uses

Denu 60mg Injection is used in the treatment of the following condition: Osteoporosis Bone loss due to hormonal therapy in breast or prostate cancer Multiple myeloma (cancer affects plasma cells in the bone marrow) Bone metastases (cancer that spreads to bone)

How it works

Denu 60mg Injection has therapeutic effects that include reducing fracture risk, increasing bone mineral density, and improving overall bone health. By inhibiting bone resorption through its action on RANK ligands, this medication helps to strengthen bones and decrease the likelihood of fractures in individuals with osteoporosis or those at high risk. It also increases bone mineral density, an important marker of bone strength. These therapeutic effects contribute to improved bone health and a reduced risk of fractures, ultimately enhancing the quality of life for patients.

Side Effects

Denu 60mg Injection can cause side effects like all medications, although not everyone who takes it will experience them. Serious: Osteonecrosis of the jaw (severe necrosis or death of jaw cells) Atypical femoral fractures Hypocalcemia (low blood calcium levels) Common: Injection site reactions Back pain Musculoskeletal pain Infections Abdominal pain Headache Hypophosphatemia (low blood phosphate levels)

Expert Tips

• Inform your doctor about your complete medical history, including previous infections, liver disease, or kidney disease. • Tell your healthcare provider about any allergies or past hypersensitivity reactions. • Seek immediate medical help if you experience severe allergic reactions or serious side effects. • Monitor calcium levels regularly, as Denu 60mg Injection may lower calcium in the blood. • Ensure adequate intake of calcium and vitamin D as advised by your doctor. • Pregnant or breastfeeding women should consult a doctor before using this medication.

References

  1. Amgen Ltd, Electronic medicines compendium (EMC), [ Revised on 13th May 2023], [ Accessed on 31st May 2023], https://www.medicines.org.uk/emc/files/pil.568.pdf
  2. Amgen Manufacturing Limited, US Food and Drug Administration, [ Revised on November 2010] [ Accessed on 31st May 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/125320s007lbl.pdf
  3. Amgen Manufacturing Limited, US Food and Drug Administration, [ Revised on November 2022] [ Accessed on 31st May 2023], https://www.fda.gov/media/163378/download

Safety Advice

Pregnancy: Consult your doctor The safety of using Denu 60mg Injection during pregnancy has not been established. Limited studies are available regarding the use of this medication in pregnant women, so it is recommended to use caution and consult a doctor before considering its use during pregnancy.

Lungs: Consult your doctor If you have a lung or respiratory disorders history, it is important to consult your healthcare provider before taking Denu 60mg Injection.

Breastfeeding: Consult your doctor Whether Denu 60mg Injection is excreted in milk is unknown. So it is better to consult a healthcare provider if you are a breastfeeding mother before taking this medication.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS