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Fragmin 5000IU Injection
Salt Composition: DALTEPARIN
- Manufacturer: PFIZER LTD
- Pack Size: 1 PREFILLED SYRINGE(s) OF 0.2ML
- Dosage Form: INJECTION
- Strength: 5000IU
- Prescription Required
- Storage: Store at room temperature, between 20°C to 25°C (68°F to 77°F). Keep away from moisture, heat, and light. It should not be frozen. Keep away from children and pets.
₹642.00₹803.70
Inclusive of all taxes
Product Introduction
Fragmin 5000IU Injection contains an active component as dalteparin. It is a medication used to prevent and treat blood clots. It is a type of anticoagulant, specifically a low molecular weight heparin (LMWH). This medication works by inhibiting the formation of blood clots, which can help reduce the risk of conditions like deep vein thrombosis (DVT) and pulmonary embolism. Deep vein thrombosis (DVT) is a blood clot that forms in a deep vein, usually in the legs. At the same time, pulmonary embolism is a serious condition that occurs when a clot travels to the lungs, potentially causing life-threatening complications. Fragmin 5000IU Injection has a more predictable anticoagulant response than unfractionated heparin, allowing for easier dosing and monitoring. It has a longer half-life, which means less frequent dosing is required compared to other anticoagulants, leading to better patient compliance. Unlike warfarin, which requires frequent international normalized ratio (INR) level monitoring, this medication typically does not need such monitoring. This medication has a lower bleeding risk than other anticoagulants, making them safer for certain patient populations. Individuals with a history of hypersensitivity or allergic reactions to Fragmin 5000IU Injection or other heparins should not use this medication. It is an anticoagulant that can increase the risk of bleeding. It should be used cautiously in patients with a history of bleeding disorders or active bleeding. Patients with severe kidney impairment may require dosage adjustments or alternative treatments, as this medication is primarily eliminated through the kidneys. It should be used cautiously in patients undergoing spinal or epidural anesthesia or lumbar puncture, as it may increase the risk of epidural or spinal hematomas, leading to paralysis.
Uses
Deep vein thrombosis (DVT) Pulmonary embolism (PE). Prevention of blood clots in medical setting
How it works
The mechanism of action of Fragmin 5000IU Injection involves its ability to bind to antithrombin III, a natural anticoagulant in the body. This binding enhances antithrombin III's ability to inactivate clotting factors, particularly factor Xa and, to a lesser extent, thrombin. By inhibiting these key clotting factors, this medication effectively prevents the formation of blood clots. It reduces the risk of thromboembolic events, such as deep vein thrombosis (DVT) and pulmonary embolism (PE).
How to Use
Fragmin 5000IU Injection is typically administered as a subcutaneous injection (under the skin). The exact dosing and administration schedule will depend on the medical condition being treated, the patient's weight, and other individual factors. It is essential to follow the instructions provided by your healthcare professional or pharmacist carefully.
Side Effects
Fragmin 5000IU Injection causes some side effects like all medications, although not everyone will experience them. Serious: Signs of bleeding Black or bloody stools Coughing up blood or blood clots Severe headache or weakness, especially on one side of the body Sudden vision changes Severe abdominal or back pain Severe or persistent dizziness or fainting Signs of an allergic reaction, including rash, itching, swelling Common: Bruising at the injection site Mild pain or redness at the injection site Bleeding from the gums or nose Mild stomach upset or nausea Mild headache Itching or skin rash
Expert Tips
Before using Fragmin 5000IU Injection, inform your healthcare provider about any bleeding disorders, history of heparin-induced thrombocytopenia, kidney or liver impairment, and any ongoing medications or medical conditions. Be vigilant for signs of bleeding, such as easy bruising or prolonged bleeding from cuts, and report any severe or persistent side effects promptly. Caution is advised when undergoing spinal or epidural anesthesia, as Fragmin 5000IU Injection may increase the risk of spinal or epidural hematomas. Regular monitoring of blood clotting factors may be necessary, especially during surgery or invasive procedures. Avoid alcohol abuse, which can further increase bleeding risk. The use during pregnancy and breastfeeding should be carefully assessed, and if you are planning long-distance travel, consult your healthcare provider for travel-related precautions. Follow all healthcare provider's instructions and attend follow-up appointments to ensure safe and effective treatment with Fragmin 5000IU Injection.
References
- KD Tripathi, Essentials of Medical Pharmacology, Drugs affecting Coagulation, Bleeding and Thrombosis, 7th edition, 2013, 619.
- Goodman & Gilmanâs, The Pharmacological Basis of Therapeutics, Blood coagulation and Anticoagulant, Fibrinolytic and Antiplatelet drugs, 12th edition, 2011, 858.
- Pfizer, Electronic medicines compendium (EMC), [Revised on 22 Feb 2023] [Accessed on 30th July 20203], https://www.medicines.org.uk/emc/product/4247/pil#gref
- Pfizer, US Food and Drug Administration, [ Revised on May 2019] [ Accessed on 30th July 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/020287s072lbl.pdf
Safety Advice
Pregnancy: Consult your doctor Pregnant women or those planning to become pregnant should discuss all potential risks and benefits of using Fragmin 5000IU Injection with their healthcare provider. The decision to use this medication during pregnancy should be made collectively, considering the specific medical condition and individual circumstances.
Lungs: Consult your doctor If you have a pre-existing lung condition or lung disease, it's essential to inform your healthcare provider before starting Fragmin 5000IU Injection or any other anticoagulant.
Breastfeeding: Consult your doctor The safety of Fragmin 5000IU Injection during breastfeeding should be assessed individually, and healthcare providers can tailor treatment plans to suit the needs of both the mother and the baby.
Disclaimer
The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.