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Gespar 3750IU Injection

Salt Composition: PEGASPARGASE

₹15770.00₹22528.13

Inclusive of all taxes

Categories: Oncology

Conditions: Anti Cancer

Product Introduction

Gespar 3750IU Injection is a chemotherapy agent containing pegaspargase as its active ingredient. It is indicated for the treatment of Acute Lymphoblastic Leukaemia (ALL), a type of blood cancer characterised by uncontrolled proliferation of immature white blood cells, which disrupts the production of functional blood cells. When used in combination with other chemotherapy drugs, this medication may improve remission rates and long-term survival outcomes in patients with ALL. It has demonstrated particular efficacy in paediatric patients with ALL, who often achieve higher remission and overall survival rates when this agent is incorporated into their treatment regimen. Gespar 3750IU Injection is typically administered alongside other chemotherapy agents for ALL treatment, especially in patients with disease resistant to prior therapies or those who have experienced relapse following initial treatment.

Glucose intolerance may occur during treatment with Gespar 3750IU Injection. Patients should contact their healthcare provider if they experience severe headaches, abdominal pain, excessive thirst, or serious allergic reactions during treatment. Patients with a history of kidney disease or pancreatic disease should discuss this medication with their healthcare provider before commencing therapy.

Uses

Gespar 3750IU Injection is indicated to treat the following conditions: Acute Lymphoblastic Leukemia Non-Hodgkin's Lymphoma

How it works

Gespar 3750IU Injection is an enzyme that breaks down the amino acid asparagine in the body. Cancer cells require asparagine to grow and divide and cannot produce their asparagine. By breaking down asparagine in the body, this medication can effectively "starve" cancer cells of this essential nutrient, slowing their growth and promoting cancer cell death. However, normal cells in the body can produce their asparagine and are not as affected by the enzyme as cancer cells. Therefore, this medicine selectively targets cancer cells while sparing healthy cells in the body to some extent.

How to Use

Gespar 3750IU Injection is typically administered by a healthcare provider as an intravenous (IV) injection in a clinical setting. The dosage and frequency of infusions will vary depending on the patient's medical condition, age, weight, and other factors. You should not take a double dose to make up the second dose.

Side Effects

Like all medications, Gespar 3750IU Injection can cause side effects, although not everyone who takes it will experience them. Serious side effects of Gespar 3750IU Injection are: Anaphylaxis (severe allergic reaction) Thrombosis (blood clots) Hemorrhage (bleeding) Tumor Lysis Syndrome (a potentially life-threatening condition due to breakdown of cancer cells) Acute pancreatitis (inflammation of the pancreas) Hepatotoxicity (liver damage or failure) Neurotoxicity (damage to the nervous system) Hypersensitivity reactions (allergic reactions, including anaphylaxis) Renal failure (kidney damage or failure) Common side effects of Gespar 3750IU Injection are: Nausea Vomiting Diarrhea Fatigue Loss of appetite Headache Fever or chills Muscle or joint pain Rash or itching Swelling or redness at the injection site

Expert Tips

If you are receiving treatment with Gespar 3750IU Injection, report any side effects or concerns promptly. If you are pregnant or planning to become pregnant or breastfeeding, it is important to discuss the risks and benefits with your healthcare provider. If patients see any sign of jaundice (yellow skin and eyes, abdominal pain, vomiting) after taking this medication, they should contact a doctor immediately because it can cause pancreas inflammation. Patients require close monitoring for any signs of abnormal bleeding or clotting. Making lifestyle changes, such as quitting smoking, maintaining a healthy weight, and eating a healthy diet, can also help support your overall health and reduce the risk of cancer-related complications. Additionally, seeking support from family members, friends, or support groups can provide patients with emotional support and help them cope with the challenges of cancer treatment.

References

  1. KD Tripathi, Essentials of Medical Pharmacology, Anticancer drugs, 7th edition, 2013, 868
  2. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Cytotoxic agents, 12th edition, 2011, 1720
  3. Les Laboratories Servier, Electronic medicines compendium (EMC), [ Revised on Nov 2021] [ Accessed on 25th April 2023], https://www.medicines.org.uk/emc/files/pil.10824.pdf
  4. Sigma-Tau Pharmaceuticals, US Food, and Drug Administration, [ Revised on March 2011] [ Accessed on 25th April 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/103411s5126lbl.pdf

Safety Advice

Pregnancy: Consult your doctor There are no established adverse effects of Gespar 3750IU Injection in pregnant women. Consult your doctor if you are pregnant or planning to get pregnant before taking this medicine.

Lungs: Consult your doctor There is no evidence to suggest that Gespar 3750IU Injection harms the lungs. However, as with any medication, there is a risk of side effects that could affect the respiratory system. So patients should consult their doctor if they have any pre-existing lung disease before taking this medication.

Breastfeeding: Consult your doctor It is unclear whether Gespar 3750IU Injection is excreted in human milk. So, you should consult a doctor before taking this medication if you are a breastfeeding mother.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS