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Gonal-F 75IU Injection

Salt Composition: FOLLICLE STIMULATING HORMONE

₹1851.00₹2056.88

Inclusive of all taxes

Categories: Gynaecology

Conditions: Women's Health

Product Introduction

Gonal-F 75IU Injection contains follitropin alfa as its active component. It is a medication used in assisted reproductive technologies (ART) to treat infertility in both men and women. This synthetic form of follicle-stimulating hormone (FSH) plays a crucial role in stimulating the development of eggs in females and sperm in males. Infertility in men and women refers to the inability to conceive after a year of regular unprotected intercourse. It stimulates the development of multiple follicles in women, enhances sperm production in men, and provides precise timing for optimal ovulation. With proven efficacy and a generally safe profile, it offers therapeutic benefit to infertile couples, increasing pregnancy rates and shortening treatment duration.

Contraindications:

Patients with a known hypersensitivity or allergic reaction to Gonal-F 75IU Injection or any of its components should avoid its use. Allergic reactions are rare but possible, requiring immediate medical attention.

Patients with ovarian cysts or tumours should avoid Gonal-F 75IU Injection, as it may exacerbate these conditions.

Patients with uncontrolled hypothyroidism or adrenal dysfunction should not use Gonal-F 75IU Injection. Uncontrolled hypothyroidism refers to a state where the levels of thyroid hormones remain inadequately regulated, causing persistent symptoms and potential complications.

Patients with abnormalities or blockages in the reproductive tract that prevent successful egg or sperm transport may not benefit from this medication.

Gonal-F 75IU Injection is not generally recommended for paediatric or elderly populations.

Uses

Gonal-F 75IU injection is used in the following: Assisted Reproductive Technologies (ART) Ovulation Induction Treatment of Male Infertility Hypogonadism

How it works

Gonal-F 75IU injection, a recombinant follicle-stimulating hormone (FSH), exerts its mechanism of action by binding to the FSH receptors on the ovarian granulosa cells in females or Sertoli cells in males. This binding stimulates the growth and development of ovarian follicles in women, leading to the maturation of eggs, and in men, it promotes the production and maturation of sperm. By mimicking the natural FSH, this medication helps regulate reproductive processes, making it valuable in infertility treatments and other related conditions.

How to Use

Gonal-F 75IU injection is administered through subcutaneous injection. Patients are typically provided with clear instructions and guidance on how to administer the injections safely and effectively during their treatment period.

Side Effects

Gonal-F 75IU injection causes some side effects like all medications, although not everyone will experience them. Serious: Severe Skin ReactionsOvarian Hyperstimulation Syndrome (OHSS) Allergic Reactions Ectopic Pregnancy Blood Clots Common: Injection Site Reactions Abdominal Discomfort Nausea Headache Fatigue

Expert Tips

Patients should be mindful of potential risks of Gonal-F 75IU injection, including Ovarian Hyperstimulation Syndrome (OHSS), multiple pregnancies, and ectopic pregnancy. Women with asthma or respiratory conditions should use it with care, and patients with pre-existing heart conditions should be closely monitored. Fertility treatments can have emotional effects, necessitating adequate psychological support. Patients must inform their healthcare providers of their complete medical history, and proper handling, dosage adjustment, and monitoring are essential. Regular ultrasound examinations and adherence to prescribed dosages are crucial, and patients should be attentive to potential risks and seek counseling and support during treatment. Other considerations include travel precautions, drug disposal, and informed consent to ensure the safest and most effective use of the medication.

References

  1. KD Tripathi, Essentials of Medical Pharmacology, Anterior pituitary hormones, 7th edition, 2013, 241.
  2. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Introduction to Endocrinology: The Hypothalamic-Pituitary Axis, 12th edition, 2011, 1123.
  3. Merck Europe BV, Electronic medicines compendium (EMC), [Revised on 17th Nov 2022] [Accessed on 2nd August 2023], https://www.medicines.org.uk/emc/product/2218/smpc#gref
  4. Serono, US Food and Drug Administration, [Revised on Dec 2020 ] [Accessed on 2nd August 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/020378s045,s067,s075lbl.pdf

Safety Advice

Pregnancy: unsafe Gonal-F 75IU injection is not recommended for use during pregnancy. If pregnancy occurs during treatment with this medication or any other fertility medications, it is crucial to inform the healthcare provider immediately

Lungs: Consult your doctor Gonal-F 75IU injection may not have direct adverse effects on the lungs, any medication can potentially cause side effects. It is important to discuss any concerns or existing lung conditions with your healthcare provider before starting this medication.

Breastfeeding: unsafe Gonal-F 75IU injection is not recommended for use during breastfeeding. It is essential to to consult with a healthcare provider before considering its use during breastfeeding.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS