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Imacyte 400mg Tablet

Salt Composition: IMATINIB

₹545.00₹2095.00

Inclusive of all taxes

Categories: Oncology

Conditions: Anti Cancer

Product Introduction

Imacyte 400mg Tablet contains imatinib, an antineoplastic agent and tyrosine kinase inhibitor. It is indicated for treating adults and children with chronic myeloid leukaemia (CML, a blood disorder involving abnormal proliferation of white blood cells) and Philadelphia chromosome-positive acute lymphoblastic leukaemia (Ph-positive ALL). The tablet is also used in myelodysplastic/myeloproliferative diseases (abnormal blood cell growth), hypereosinophilic syndrome, chronic eosinophilic leukaemia, gastrointestinal stromal tumours (cancers of the stomach and bowel), and dermatofibrosarcoma protuberans (cancer in subcutaneous tissue).

Do not take Imacyte 400mg Tablet if you are allergic to imatinib or any other ingredient in this medicine. Before beginning treatment, inform your physician if you have kidney, heart, or liver problems, thyroid disorders, or if your thyroid gland has been removed. Notify your doctor if you have a history of or current hepatitis B infection, as this medicine may reactivate hepatitis B. Report symptoms of bruising, bleeding, fever, fatigue, and confusion whilst taking this medicine. Inform your doctor if you are planning pregnancy, think you may be pregnant, or are breastfeeding.

Uses

Chronic myeloid leukemia (CML) Philadelphia chromosome-positive acute lymphoblastic leukemia (ph-positive ALL) Myelodysplastic/myeloproliferative diseases (MDS/MPD) Hypereosinophilic syndrome (HES) Chronic eosinophilic leukemia (CEL) Dermatofibrosarcoma protuberans (DFSP) Gastrointestinal stromal tumors (GIST)

How it works

Imacyte 400mg Tablet is a protein-tyrosine kinase inhibitor that blocks a specific abnormal protein created by a chromosomal abnormality that signals cancer cells to multiply. It inhibits the multiplication and induces cell death in abnormal cancer cells.

How to Use

Your doctor will decide the dose and duration of the treatment based on your disease condition, severity and other factors. Take the tablets as prescribed by your doctor. Do not break, crush, or chew the tablets. Swallow the tablet whole with a glass of water. Take this medicine with a meal to avoid stomach problems. If you are unable to swallow the tablets, you can dissolve them as per your doctor's advice.

Side Effects

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Common: Swelling in the face, legs, ankle and feet Bruising Nausea Vomiting Weight gain Disturbed sense of taste Feeling dizzy or weak Eye problem (discharging, itching, redness or swelling) Nose bleeds Itching Unusual hair loss Muscle cramps and pain Diarrhea Numbness (hands or feet) Mouth ulcers. Joint pain with swelling. Dryness (eye, mouth and skin) Decreased or increased skin sensitivity. Hot flushes, chills or night sweats. Tiredness or dizziness Abdominal pain Headache Serious: Heart problem Lung or respiratory problem Blood disorder Chronic renal failure Retarding of growth in children GI disorders Hypothyroidism Liver failure Swelling in the body

Expert Tips

It is recommended to drink a sufficient amount of water or electrolyte to compensate for the water loss during the diarrhoea or vomiting. It is recommended to take enough rest for a fast recovery. It is advised to avoid eating junk and oily foods which worsen the adverse effect of the drug. Your doctor will advise you to do a blood test and weight check during the medication. Applying a small amount of honey in the mouth ulcer, it will help you to relieve the pain caused by the ulcer.

References

  1. Cipla (EU) Limited, Electronic Medicine Compendium (EMC), [Revised on Dec 2023], [Accessed on Mar 2024], https://www.medicines.org.uk/emc/files/pil.10133.pdf
  2. Novartis Pharmaceuticals Corporation, US Food and Drug Administration, [Revised on Sep 2016], [Accessed on Mar 2024], https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021588s047lbl.pdf
  3. KD Tripathi, Anticancer Drugs, Essentials of Medical Pharmacology, 8th Edition, 2019, 915-936.

Safety Advice

Pregnancy: unsafe Imacyte 400mg Tablet is unsafe to administer in pregnant women because it may affect the fetus. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant.

Lungs: Consult your doctor It is unknown whether Imacyte 400mg Tablet can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.

Breastfeeding: unsafe Breastfeeding is not recommended in patients taking Imacyte 400mg Tablet because the medicine passes into the breast milk in small amounts and may harm your baby.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS