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Indirab Injection

Salt Composition: PURIFIED VERO CELL RABIES VACCINE

₹358.00₹397.62

Inclusive of all taxes

Indirab Injection

Categories: Infectious Disease

Conditions: Injections & Vaccine

Product Introduction

Indirab Injection contains a Purified Vero Cell Rabies vaccine, indicated for prevention and treatment of rabies before and after exposure to the virus. The vaccine is manufactured by growing the rabies virus in Vero cells, then purifying it to remove unwanted substances. The purified virus is inactivated, meaning it can no longer cause disease but stimulates an immune response. Pre-exposure vaccination is recommended for travellers, those in high-risk occupations, and children living in rabies-prone areas. Post-exposure prophylaxis involves prompt wound management and vaccination. This vaccine is prepared from the Pitman-Moore strain of the Rabies virus grown in Vero cells. Rabies is an acute, progressive disease caused by the rabies virus belonging to the Rhabdoviridae family. It spreads through the saliva of infected animals following bites or scratches. Although this infection is 100% fatal, it is 100% preventable with timely measures and correct use of available vaccines, immunoglobulins, or monoclonal antibodies. Patients with known hypersensitivity to Indirab Injection or its components should not receive it. If a patient is currently experiencing moderate to severe illness, vaccination may be delayed until recovery. However, mild illness, such as a common cold, does not typically preclude vaccination.

Uses

Indirab Injection is used in the following: Immunization before possible exposure to rabies Post-exposure treatment after exposure to a suspected rabid animal Prevention of infection for high-risk people (veterinarians, municipal workers, medical and paramedical workers)

How it works

The Indirab Injection works by introducing inactivated rabies virus particles to the body. This exposure triggers an immune response, producing specific antibodies that recognize and target the rabies virus. If a vaccinated person subsequently encounters the virus, their immune system is primed to quickly recognize and neutralize it, preventing it from causing it.

How to Use

The Indirab Injection is typically given as a series, with the exact schedule determined by healthcare professionals based on factors such as age, health status, and risk of exposure to rabies. The injections are usually given in the upper arm for adults and older children or in the thigh muscle for infants and young children.

Side Effects

Indirab Injection cause some side effects like all medications, although not everyone will experience them. Serious: Anaphylactic reactions (severe allergic reaction) Common: Pain Swelling Pruritus at the site of injection Fever Shivering Fainting Headache Dizziness Muscle pain Nausea Vomiting Stomach pain Dry mouth

Expert Tips

If you are considering getting Indirab Injection, you should know the potential risks and warnings associated with the vaccine. Pregnant and breastfeeding women should always consult a doctor before taking it. Inform your physician before beginning treatment if you have or ever had a mental illness, seziures, hepatitis infection, skin rashes, or any other signs of infection or inflammation. Reporting any adverse events is crucial for ongoing safety monitoring. Consulting with a healthcare professional is essential to address specific concerns and ensure appropriate vaccination decisions.

References

  1. Sudarshan MK. World Health Organization 2018 Guidelines on Rabies Prophylaxis: Contentious Issues. Pediatr Inf Dis 2019;1(4):154–156, https://www.pidjournal.com/doi/PID/pdf/10.5005/jp-journals-10081-1226
  2. Thomas Moulenat et al., Purified Vero Cell Rabies vaccine (PVRV, Verorab®): A Systematic Review of Intradermal Use Between 1985 and 2019, Trop. Med. Infect. Dis., 2020, 5, 40, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157209/pdf/tropicalmed-05-00040.pdf
  3. Bharat Biotech International Ltd, [Revised on Aug 2018] [Accessed on 22nd May 2023], https://www.bharatbiotech.com/images/indirab/Indirab-Package-Insert.pdf
  4. AbhayRIG, [Accessed on 22nd May 2023], https://www.cphi-online.com/46/resourcefile/09/72/83/IIL%20Human%20Health%20Vaccine%20Brochure.pdf
  5. KD Tripathi, Vaccines, Antisera and lmmuneglobulins, Essentials of Medical Pharmacology, 8th Edition, 2019, 978-986.

Safety Advice

Pregnancy: Consult your doctor The safety of the Indirab Injection during pregnancy has not been extensively studied. So Before taking it women should consult the concerned doctor if they are pregnant or think they might be pregnant

Lungs: Consult your doctor Patients with pre-existing lung disorders should consult a doctor before taking the Indirab Injection.

Breastfeeding: Consult your doctor Breastfeeding women should always consult a doctor before taking the Indirab Injection.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS