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Irinotel 40mg Injection
Salt Composition: IRINOTECAN
- Manufacturer: FRESENIUS KABI INDIA PVT LTD
- Pack Size: 1 VIAL(s) OF 2ML
- Dosage Form: INJECTION
- Strength: 40MG
- Prescription Required
- Storage: Do not freeze. Store protected from light at a temperature not exceeding 25°C. Keep this medicine away from the sight and reach of children.
₹414.00₹486.69
Inclusive of all taxes
Product Introduction
Irinotel 40 mg Injection is an anti-cancer medicine belonging to the cytostatic drug class and contains irinotecan hydrochloride trihydrate as the active ingredient. It is indicated for advanced colon cancer and rectal cancer in adults. Irinotel 40 mg is used to treat these cancers either as monotherapy or in combination with other chemotherapeutic agents. Colon and rectal cancer incidence is higher in age groups above 50 years and can be influenced by genetic and environmental factors. Irinotel 40 mg is prescribed in colon cancer to manage disease progression and improve patient outcomes. The medication works by interfering with the growth and multiplication of cancer cells. Irinotel 40 mg works by inhibiting topoisomerase I, an enzyme necessary for DNA replication in cancer cells, thereby slowing tumour growth and promoting cancer cell death. Common adverse effects of Irinotel 40 mg Injection include myelosuppression (bone marrow suppression resulting in low levels of red blood cells, white blood cells, and platelets) and diarrhoea. Other side effects may include nausea, vomiting, abdominal pain, constipation, anaemia, fatigue, fever, infections including sepsis, abnormal bilirubin levels, alopecia, and weight loss. Patients should inform their doctor if these side effects persist or significantly affect their daily life.
Uses
Treatment of metastatic cancer of the colon and rectum (large intestine).
How it works
Irinotel 40 mg Injection works by converting its active metabolite with the help of liver enzymes and inhibits the Topoisomerase I enzyme. This causes damage to the DNA synthesis and its replication, thus preventing the cancer cells from growing and spreading.
Side Effects
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Irinotel 40mg side effects are Serious: Early and late diarrhea Allergic reactions Kidney impairment Lung problems Low levels of RBC, WBC, and platelets in the blood Common: Nausea, vomiting, abdominal pain Constipation Diarrhea Anemia Pain Fatigue Fever, infections including sepsis Abnormal bilirubin levels Hair loss Weight loss
References
- Accord Healthcare Limited, Electronic Medicines Compendium (EMC), [Revised on June 2022] [Accessed on 24 Nov 2022], https://www.medicines.org.uk/emc/files/pil.7318.pdf
- Pharmacia & Upjohn Co, US Food & Drug Administration, [Revised on Dec 2014] [Accessed on 24 Nov 2022], https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/020571s048lbl.pdf
- I.D. Penman, C.W. Lees, Alimentary Tract and Pancreatic Disease, Davidsonâs Principles and Practice of Medicine, 22nd Edition, 2014, 837-920.
- Edward Chu, Cancer Chemotherapy, Langeâs Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.
Safety Advice
Pregnancy: unsafe Irinotel 40 mg Injection is unsafe to use during pregnancy as it may harm the developing baby. Women who have potential childbearing use effective contraceptives during and after 6 months after treatment.
Lungs: Consult your doctor It is unknown whether it is safe to administer Irinotel 40 mg Injection in patients with lung disorders. Please consult your doctor for more advice.
Breastfeeding: unsafe It is unsafe to use during breastfeeding as Irinotel 40 mg Injection, and its metabolites are found in human milk. It must be discontinued for the duration of therapy. Consult your doctor for advice.
Disclaimer
The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.