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Irnocam 40mg Injection

Salt Composition: IRINOTECAN

₹665.00₹831.44

Inclusive of all taxes

Categories: Oncology

Conditions: Anti Cancer

Product Introduction

Irnocam 40 mg Injection is an anti-cancer medicine belonging to the group of cytostatics. It contains the active ingredient Irinotecan hydrochloride trihydrate. The medication is indicated for advanced colon cancer and rectal cancer in adults. It may be prescribed as monotherapy or in combination with other chemotherapeutic agents. Colon and rectal cancer occurs more frequently in age groups above 50 years and is associated with genetic and environmental factors.

Myelosuppression (bone marrow suppression resulting in reduced levels of red blood cells, white blood cells, and platelets) and diarrhea are the most common adverse effects. Other frequently reported side effects include nausea, vomiting, abdominal pain, constipation, anaemia, pain, fatigue, fever, infections including sepsis, abnormal bilirubin levels, hair loss, and weight loss. Inform your doctor if these side effects occur or persist.

Notify your doctor if you are allergic to Irnocam 40 mg Injection or any of its ingredients. Before commencing treatment, inform your physician of any existing liver problems or jaundice, kidney or heart problems, asthma, high blood pressure or high cholesterol, or severe diarrhea. If you smoke or have received radiation therapy previously, report this to your healthcare provider. Discuss all other medicines, herbal products, and supplements you are taking with your healthcare provider. Effective contraception by both males and females during treatment is necessary to prevent pregnancy. Your physician will conduct blood tests before treatment and during therapy to monitor the medicine's effects on blood counts and blood chemistry.

Uses

Treatment of metastatic cancer of the colon and rectum (large intestine).

How it works

Irnocam 40 mg Injection works by converting its active metabolite with the help of liver enzymes and inhibits the Topoisomerase I enzyme. This causes damage to the DNA synthesis and its replication, thus preventing the cancer cells from growing and spreading.

How to Use

Take this medicine exactly as prescribed. Your healthcare professional administers it into your vein. Do not self-administer. Your physician will recommend a DNA test before taking this medicine. The dose depends on your age, size, and medical condition.

Side Effects

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Serious: Early and late diarrhea Allergic reactions Kidney impairment Lung problems Low levels of RBC, WBC, and platelets in the blood Common: Nausea, vomiting, abdominal pain Constipation Diarrhea Anemia Pain Fatigue Fever, infections including sepsis Abnormal bilirubin levels Hair loss Weight loss

Expert Tips

Diarrhea is the first sign of Irnocam 40 mg Injection. It may be serious if diarrhea starts more than 24 hours after administration of this medication. It should be treated immediately and kept under close supervision. If left untreated, it could lead to dehydration and serious chemical imbalances, which can be life-threatening. Try to avoid laxatives and stool softeners while taking this medicine. Drink large amounts of water and rehydration fluids immediately. Take antidiarrheal treatment like loperamide.

References

  1. Pharmacia & Upjohn Co, US Food & Drug Administration, [Revised on Dec 2014] [Accessed on 24 Nov 2022], https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/020571s048lbl.pdf
  2. I.D. Penman, C.W. Lees, Alimentary Tract and Pancreatic Disease, Davidson’s Principles and Practice of Medicine, 22nd Edition, 2014, 837-920.
  3. Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.

Safety Advice

Pregnancy: unsafe Take this medicine exactly as prescribed. Your healthcare professional administers it into your vein. Do not self-administer. Your physician will recommend a DNA test before taking this medicine. The dose depends on your age, size, and medical condition.

Lungs: Consult your doctor It is unknown whether it is safe to administer Irnocam 40 mg Injection in patients with lung disorders. Please consult your doctor for more advice.

Breastfeeding: unsafe It is unsafe to use during breastfeeding as Irnocam 40 mg Injection, and its metabolites are found in human milk. It must be discontinued for the duration of therapy. Consult your doctor for advice.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS