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Kabonib 60mg Tablet

Salt Composition: CABOZANTINIB

₹11138.00₹13921.88

Inclusive of all taxes

Categories: Oncology

Conditions: Anti Cancer

Product Introduction

Kabonib 60mg Tablet is an antineoplastic drug containing Cabozantinib, a tyrosine kinase inhibitor. In adults, it is used to treat advanced kidney cancer and locally advanced or metastatic differentiated thyroid cancer. It is also indicated for liver cancer when Sorafenib is no longer effective. For advanced kidney cancer, this medicine is typically administered in combination with Nivolumab. It is not recommended for patients younger than 18 years. Do not use this medicine if you are allergic to Cabozantinib or any other ingredients in Kabonib 60mg Tablet. Inform your physician if you have liver disease, inflammatory bowel disease, high blood pressure, heart disease, or diarrhoea. Notify your doctor of any history of blood clots in the leg, significant bleeding, aneurysm, or tears in the blood vessel wall. Inform your physician if you are pregnant or planning to become pregnant. Use effective contraception during treatment and for four months after treatment. Discuss fertility concerns with your doctor. Before starting Kabonib 60mg Tablet, notify your doctor if you have a thyroid problem; thyroid function must be monitored before initiating the medicine. Inform your physician if you have had any surgery, including dental surgery, within the last month. Avoid consuming grapefruit or grapefruit juice during treatment as they may increase medicine levels in the blood. This medicine contains lactose; if you have lactose intolerance, inform your doctor before taking the medicine.

Uses

Kabonib 60mg Tablet is indicated to treat the following conditions: Advanced renal cell carcinoma Liver Cancer Differentiated thyroid cancer

How it works

It acts against a protein called receptor tyrosine kinases and interferes with cell signaling, ultimately stopping the growth and spread of cancer cells. Kabonib 60mg Tablet is indicated alone or in combination with Nivolumab.

How to Use

Take Kabonib 60mg Tablet as advised by your physician. Usually, this medicine will be given once a day. Do not crush, chew, or open the medicine. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Only stop taking Kabonib 60mg Tablet if your doctor advises you to stop.

Side Effects

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Serious Gastrointestinal perforation Severe or uncontrollable bleeding Shortness of breath Nonhealing wound Pain in the mouth, jaw/teeth, hand, feet, Loss of consciousness, Drowsy Swelling or sores in the mouth Blood vomiting Black stools Blood in urine Headache Coughing blood Common: Dehydration Difficulty swallowing Ringing in the ears Blood clots in the veins Fluctuation in the blood sugar levels The lower level of albumin Electrolyte imbalance Increased levels of liver enzymes Elevated cholesterol levels in the blood Hair loss Changes in hair color Muscle spasm Skin thickening Dry skin Itching Protein in urine

Expert Tips

Oral contraception may be ineffective while under the treatment of Kabonib 60mg Tablet. Discuss effective contraception methods with your doctor, along with fertility concerns. Inform your doctor if you have a thyroid problem; thyroid function should be monitored regularly before taking this medicine. Notify your doctor if your face gets colder or tired more commonly or if your voice deepens while taking this medicine. Do not stop the medicine until your doctor advises. Notify your doctor if you experience any serious side effects. You are doctor may change your dose or stop the treatment. Your doctor will inform you if you need any dose adjustments. This medicine is not recommended for children or adolescents.

References

  1. Ipsen Pharma, Electronic Medicines Compendium (EMC), [Revised on July 2022] [Accessed on 25th April 2023], Cabometyx 20 mg Film-coated Tablets - Summary of Product Characteristics (SmPC) - (emc) (medicines.org.uk)
  2. Exelixis, Inc., [Revised on Oct 2020] [Accessed on 25th April 2023], https://www.cometriq.com/downloads/Cometriq_Full_Prescribing_Information.pdf
  3. Gregory A. Brent and Ronald J. Koenig, Thyroid and Antithyroid Drugs, Goodman & Gilman’s Pharmacological Basis of Therapeutics, 2018, 787-801.

Safety Advice

Pregnancy: unsafe Kabonib 60mg Tablet is unsafe to use during pregnancy as it may harm the unborn baby. Report to your doctor if you are pregnant or think you may be pregnant or planning for the pregnancy before starting the treatment.

Lungs: Consult your doctor It is unknown whether Kabonib 60mg Tablet is safe to administer in patients with lung problems. Inform your physician if you have any lung disease before starting the treatment. Contact your doctor if you experience any lung-related symptoms.

Breastfeeding: unsafe Taking Kabonib 60mg Tablet while breastfeeding may be unsafe because it may affect the child. Do not breastfeed for at least four months after the treatment. Therefore, talk with your doctor to get more information.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS