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Keygraf 2mg Capsule

Salt Composition: TACROLIMUS

₹720.00₹900.00

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Keygraf 2mg Capsule

Categories: Nephrology

Conditions: Transplant

Product Introduction

Keygraf 2mg Capsule contains tacrolimus, an immunosuppressant belonging to the calcineurin inhibitor class of medications. It is used alongside other medicines to prevent organ transplant rejection in patients receiving liver, kidney, heart, or other organ transplants. The capsule works by controlling your body's immune response, allowing it to accept the transplanted organ.

Do not take Keygraf 2mg Capsule if you are allergic to tacrolimus or any other ingredients in this medicine. Inform your doctor if you are allergic to any antibiotic group. Tell your doctor if you have or have had liver or heart disease before starting treatment.

Notify your doctor immediately if you develop fever, bruising under the skin (appearing as red dots), unexplained tiredness, confusion, yellowing of the skin or eyes, reduced urine output, vision loss, or seizures after taking this medicine.

Limit your exposure to sunlight and UV light while taking Keygraf 2mg Capsule by wearing appropriate protective clothing and sunscreen with a high sun protection factor, as immunosuppressive therapy carries a potential risk of malignant skin changes.

This medicine may cause diarrhea. Inform your doctor if diarrhea persists for over a day.

Before receiving any vaccinations, consult your doctor.

Uses

Prevent organ transplant rejections.

How it works

Keygraf 2mg Capsule provides immunosuppression by inhibiting T-lymphocyte activation and proliferation and T-helper-cell-dependent B-cell response. It works by attaching to a protein called FKBP-12 and forms a complex called tacrolimus-FKBP, which inhibits the action of calcineurin phosphatase. This, in turn, inhibits the formation of T cells and suppresses the immune response.

How to Use

Your doctor will decide the dose and duration of the treatment based on your disease condition, severity, and other factors. Always take Keygraf 2mg Capsule as prescribed by your doctor. Do not open, break, crush, or chew the capsules. Swallow the capsule whole with a glass of water. Take these capsules on an empty stomach or at least 1 hour before or 2 to 3 hours after the meal.

Side Effects

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Common Swelling in the arm or leg Hair loss Itchy skin Constipation, diarrhea Nausea, vomiting Anemia Headache Cough Serious Increased or decreased heartbeats GI bleeding Liver Injury Seizure Acute kidney failure Lung infection or respiratory problems

Expert Tips

Do not eat grapefruit or drink grapefruit juice while you are using Keygraf 2mg Capsule. Do not drink alcohol while you are using this medicine. This medicine may interfere with the vaccine. Ask your healthcare professional before getting a flu shot or other vaccines. You must take this medicine as a long-term treatment to prevent rejection of your transplanted organ. Do not stop taking this medicine without informing your doctor. Your doctor may advise you to take certain tests to monitor the effectiveness and side effects of the therapy. Keep all your appointments regularly.

References

  1. Prograf 0.5mg Hard Capsules - Summary of Product Characteristics (SmPC) - (emc). www.medicines.org.uk. Published December 2022. Accessed May 25, 2023. https://www.medicines.org.uk/emc/product/6720/smpc
  2. Highlights Of Prescribing Information, Prograf ® (Tacrolimus) Capsules PROGRAF ® (Tacrolimus) Injection, (for Intravenous Use).; Revised 2012. Accessed May 25, 2023. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/050709s031lbl.pdf
  3. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Immunosuppressants, tolerogens, and immunostimulants, 12th edition, 2011, 1008.
  4. KD Tripathi, Essentials of Medical Pharmacology, Immunosuppressant drugs, 7th edition, 2013, 881.

Safety Advice

Pregnancy: Consult your doctor Based on animal studies, Keygraf 2mg Capsule can cause harmful effects on the baby. Inform your physician if you are pregnant, suspecting pregnancy or planning to get pregnant before initiating the treatment.

Lungs: Consult your doctor It is unknown whether Keygraf 2mg Capsule can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.

Breastfeeding: unsafe Do not consume Keygraf 2mg Capsule if you are breastfeeding because this medicine is excreted into breast milk and may cause harmful effects on the body.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS